1T37
Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between group I phospholipase A2 and a designed pentapeptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phospholipase A2 isoform 3 | polymer | 119 | 13172.5 | 1 | UniProt (P60045) Pfam (PF00068) In PDB | Naja sagittifera | Phosphatidylcholine 2-acylhydrolase |
| 2 | P | Synthetic peptide | polymer | 5 | 565.7 | 1 | |||
| 3 | A | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 4 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 1 - 119 (UniProt: P60045)
| PDB | External Database | Details |
|---|---|---|
| Ala 20 | Gln 26 | engineered mutation |
| Thr 47 | Val 53 | engineered mutation |
| Asp 108 | Ala 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13738.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 177.1 | |
| All* | Total formula weight | 13915.3 |
