Author results

2BVJ
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LIGAND-FREE STRUCTURE OF CYTOCHROME P450 PIKC (CYP107L1)
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, BETA-MERCAPTOETHANOL, ...
Authors:Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.
Deposit date:2005-06-28
Release date:2006-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 281, 2006
2C6H
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CRYSTAL STRUCTURE OF YC-17-BOUND CYTOCHROME P450 PIKC (CYP107L1)
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE, ...
Authors:Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.
Deposit date:2005-11-09
Release date:2006-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 281, 2006
2C7X
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CRYSTAL STRUCTURE OF NARBOMYCIN-BOUND CYTOCHROME P450 PIKC (CYP107L1)
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, NARBOMYCIN
Authors:Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.
Deposit date:2005-11-29
Release date:2006-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 281, 2006
2CD8
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CRYSTAL STRUCTURE OF YC-17-BOUND CYTOCHROME P450 PIKC (CYP107L1)
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE
Authors:Yermalitskaya, L.I., Kim, Y., Sherman, D.H., Waterman, M.R., Podust, L.M.
Deposit date:2006-01-20
Release date:2007-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 281, 2006
1GWI
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THE 1.92 A STRUCTURE OF STREPTOMYCES COELICOLOR A3(2) CYP154C1: A NEW MONOOXYGENASE THAT FUNCTIONALIZES MACROLIDE RING SYSTEMS
Descriptor:CYTOCHROME P450 154C1, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Podust, L.M., Kim, Y., Arase, M., Neely, B.A., Beck, B.J., Bach, H., Sherman, D.H., Lamb, D.C., Kelly, S.L., Waterman, M.R.
Deposit date:2002-03-15
Release date:2003-01-29
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The 1.92 A Structure of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase that Functionalizes Macrolide Ring Systems
J.Biol.Chem., 278, 2003
1ODO
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1.85 A STRUCTURE OF CYP154A1 FROM STREPTOMYCES COELICOLOR A3(2)
Descriptor:PUTATIVE CYTOCHROME P450 154A1, PROTOPORPHYRIN IX CONTAINING FE, 4-PHENYL-1H-IMIDAZOLE
Authors:Podust, L.M., Kim, Y., Arase, M., Bach, H., Sherman, D.H., Lamb, D.C., Kelly, S.L., Waterman, M.R.
Deposit date:2003-02-19
Release date:2004-01-02
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Comparison of the 1.85 A Structure of Cyp154A1 from Streptomyces Coelicolor A3(2) with the Closely Related Cyp154C1 and Cyps from Antibiotic Biosynthetic Pathways.
Protein Sci., 13, 2004
2CA0
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CRYSTAL STRUCTURE OF YC-17-BOUND CYTOCHROME P450 PIKC (CYP107L1)
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE
Authors:Yermalitskaya, L.I., Kim, Y., Sherman, D.H., Waterman, M.R., Podust, L.M.
Deposit date:2005-12-15
Release date:2006-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Yc-17-Bound Cytochrome P450 Pikc (Cyp107L1)
To be Published
2H7X
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PIKROMYCIN THIOESTERASE ADDUCT WITH REDUCED TRIKETIDE AFFINITY LABEL
Descriptor:Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ...
Authors:Giraldes, J.W., Akey, D.L., Kittendorf, J.D., Sherman, D.H., Smith, J.S., Fecik, R.A.
Deposit date:2006-06-05
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels
NAT.CHEM.BIOL., 2, 2006
2H7Y
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PIKROMYCIN THIOESTERASE WITH COVALENT AFFINITY LABEL
Descriptor:Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ...
Authors:Giraldes, J.W., Akey, D.L., Kittendorf, J.D., Sherman, D.H., Smith, J.S., Fecik, R.A.
Deposit date:2006-06-06
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels
NAT.CHEM.BIOL., 2, 2006
2HFJ
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PIKROMYCIN THIOESTERASE WITH COVALENT PENTAKETIDE AFFINITY LABEL
Descriptor:Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ...
Authors:Akey, D.L., Kittendorf, J.D., Giraldes, J.W., Fecik, R.A., Sherman, D.H., Smith, J.L.
Deposit date:2006-06-24
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for Macrolactonization by the Pikromycin Thioesterase
NAT.CHEM.BIOL., 2, 2006
2HFK
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PIKROMYCIN THIOESTERASE IN COMPLEX WITH PRODUCT 10-DEOXYMETHYNOLIDE
Descriptor:Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ...
Authors:Akey, D.L., Kittendorf, J.D., Giraldes, J.W., Fecik, R.A., Sherman, D.H., Smith, J.L.
Deposit date:2006-06-24
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis for Macrolactonization by the Pikromycin Thioesterase
NAT.CHEM.BIOL., 2, 2006
2LIU
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NMR STRUCTURE OF HOLO-ACPI DOMAIN FROM CURA MODULE FROM LYNGBYA MAJUSCULA
Descriptor:CurA
Authors:Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H., Guntert, P., Dotsch, V.
Deposit date:2011-09-01
Release date:2011-12-14
Last modified:2012-03-14
Method:SOLUTION NMR
Cite:Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase.
Acs Chem.Biol., 7, 2012
2LIW
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NMR STRUCTURE OF HMG-ACPI DOMAIN FROM CURA MODULE FROM LYNGBYA MAJUSCULA
Descriptor:CurA, 4'-PHOSPHOPANTETHEINE, 3-HYDROXY-3-METHYL-GLUTARIC ACID
Authors:Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H., Guntert, P., Dotsch, V.
Deposit date:2011-09-01
Release date:2011-12-21
Last modified:2012-03-14
Method:SOLUTION NMR
Cite:Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase.
Acs Chem.Biol., 7, 2012
2VZ7
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CRYSTAL STRUCTURE OF THE YC-17-BOUND PIKC D50N MUTANT
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE
Authors:Li, S., Sherman, D.H., Podust, L.M.
Deposit date:2008-07-30
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 284, 2009
2VZM
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CRYSTAL STRUCTURE OF THE NARBOMYCIN-BOUND PIKC D50N MUTANT
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, NARBOMYCIN
Authors:Li, S., Sherman, D.H., Podust, L.M.
Deposit date:2008-08-01
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 284, 2009
2WHW
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SELECTIVE OXIDATION OF CARBOLIDE C-H BONDS BY ENGINEERED MACROLIDE P450 MONOOXYGENASE
Descriptor:CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CYCLOTRIDECYL 3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSIDE, ...
Authors:Li, S., Chaulagain, M.R., Knauff, A.R., Podust, L.M., Montgomery, J., Sherman, D.H.
Deposit date:2009-05-07
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Oxidation of Carbolide C-H Bonds by an Engineered Macrolide P450 Mono-Oxygenase.
Proc.Natl.Acad.Sci.USA, 106, 2009
2WI9
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SELECTIVE OXIDATION OF CARBOLIDE C-H BONDS BY ENGINEERED MACROLIDE P450 MONOOXYGENASE
Descriptor:CYTOCHROME P450 HYDROXYLASE PIKC, PROTOPORPHYRIN IX CONTAINING FE, CYCLODODECYL 3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSIDE, ...
Authors:Li, S., Chaulagain, M.R., Knauff, A.R., Podust, L.M., Montgomery, J., Sherman, D.H.
Deposit date:2009-05-08
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective Oxidation of Carbolide C-H Bonds by an Engineered Macrolide P450 Mono-Oxygenase.
Proc.Natl.Acad.Sci.USA, 106, 2009
2Y08
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STRUCTURE OF THE SUBSTRATE-FREE FAD-DEPENDENT TIRANDAMYCIN OXIDASE TAML
Descriptor:TAML, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Carlson, J.C., Li, S., Gunatilleke, S.S., Anzai, Y., Burr, D.A., Podust, L.M., Sherman, D.H.
Deposit date:2010-11-30
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes
Nat.Chem, 3, 2011
2Y3R
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STRUCTURE OF THE TIRANDAMYCIN-BOUND FAD-DEPENDENT TIRANDAMYCIN OXIDASE TAML IN P21 SPACE GROUP
Descriptor:TAML, FLAVIN-ADENINE DINUCLEOTIDE, TIRANDAMYCIN E, ...
Authors:Carlson, J.C., Li, S., Gunatilleke, S.S., Anzai, Y., Burr, D.A., Podust, L.M., Sherman, D.H.
Deposit date:2010-12-22
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes
Nat.Chem, 3, 2011
2Y3S
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STRUCTURE OF THE TIRANDAMYCINE-BOUND FAD-DEPENDENT TIRANDAMYCIN OXIDASE TAML IN C2 SPACE GROUP
Descriptor:TAML, FLAVIN-ADENINE DINUCLEOTIDE, TIRANDAMYCIN E, ...
Authors:Carlson, J.C., Li, S., Gunatilleke, S.S., Anzai, Y., Burr, D.A., Podust, L.M., Sherman, D.H.
Deposit date:2010-12-23
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes
Nat.Chem, 3, 2011
2Y46
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STRUCTURE OF THE MIXED-FUNCTION P450 MYCG IN COMPLEX WITH MYCINAMICIN IV IN C 2 2 21 SPACE GROUP
Descriptor:P-450-LIKE PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, MYCINAMICIN IV, ...
Authors:Li, S., Kells, P.M., Sherman, D.H., Podust, L.M.
Deposit date:2011-01-05
Release date:2012-01-25
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions.
J.Biol.Chem., 287, 2012
2Y4G
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STRUCTURE OF THE TIRANDAMYCIN-BOUND FAD-DEPENDENT TIRANDAMYCIN OXIDASE TAML IN P212121 SPACE GROUP
Descriptor:TAML, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Carlson, J.C., Li, S., Gunatilleke, S.S., Anzai, Y., Burr, D.A., Podust, L.M., Sherman, D.H.
Deposit date:2011-01-05
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes
Nat.Chem, 3, 2011
2Y5N
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STRUCTURE OF THE MIXED-FUNCTION P450 MYCG IN COMPLEX WITH MYCINAMICIN V IN P21 SPACE GROUP
Descriptor:P-450-LIKE PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, MYCINAMICIN V, ...
Authors:Li, S., Kells, P.M., Sherman, D.H., Podust, L.M.
Deposit date:2011-01-15
Release date:2012-02-01
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions.
J.Biol.Chem., 287, 2012
2Y5Z
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MIXED-FUNCTION P450 MYCG IN COMPLEX WITH MYCINAMICIN III IN C2221 SPACE GROUP
Descriptor:P-450-LIKE PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, MYCINAMICIN III, ...
Authors:Li, S., Kells, P.M., Sherman, D.H., Podust, L.M.
Deposit date:2011-01-19
Release date:2012-02-01
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions.
J.Biol.Chem., 287, 2012
2Y98
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STRUCTURE OF THE MIXED-FUNCTION P450 MYCG IN COMPLEX WITH MYCINAMICIN IV IN P21212 SPACE GROUP
Descriptor:P-450-LIKE PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, MYCINAMICIN IV, ...
Authors:Li, S., Kells, P.M., Sherman, D.H., Podust, L.M.
Deposit date:2011-02-12
Release date:2012-02-22
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions.
J.Biol.Chem., 287, 2012
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