Author results

2FUQ
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CRYSTAL STRUCTURE OF HEPARINASE II
Descriptor:heparinase II protein, ALPHA-L-RHAMNOSE, ALPHA-D-MANNOSE, ...
Authors:Shaya, D., Cygler, M.
Deposit date:2006-01-27
Release date:2006-04-18
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Heparinase II from Pedobacter heparinus and Its Complex with a Disaccharide Product.
J.Biol.Chem., 281, 2006
2FUT
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CRYSTAL STRUCTURE OF HEPARINASE II COMPLEXED WITH A DISACCHARIDE PRODUCT
Descriptor:heparinase II protein, ZINC ION, HEPARIN DISACCHARIDE I-S
Authors:Shaya, D., Cygler, M.
Deposit date:2006-01-27
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Heparinase II from Pedobacter heparinus and Its Complex with a Disaccharide Product.
J.Biol.Chem., 281, 2006
2Q1F
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CRYSTAL STRUCTURE OF CHONDROITIN SULFATE LYASE ABC FROM BACTEROIDES THETAIOTAOMICRON WAL2926
Descriptor:Chondroitinase, CALCIUM ION, PHOSPHATE ION
Authors:Shaya, D., Cygler, M.
Deposit date:2007-05-24
Release date:2008-01-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid.
Glycobiology, 18, 2008
3E7J
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HEPARINASEII H202A/Y257A DOUBLE MUTANT COMPLEXED WITH A HEPARAN SULFATE TETRASACCHARIDE SUBSTRATE
Descriptor:Heparinase II protein, ZINC ION, ACETATE ION, ...
Authors:Shaya, D., Cygler, M.
Deposit date:2008-08-18
Release date:2008-12-30
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
J.Biol.Chem., 285, 2010
3E80
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STRUCTURE OF HEPARINASE II COMPLEXED WITH HEPARAN SULFATE DEGRADATION DISACCHARIDE PRODUCT
Descriptor:Heparinase II protein, ZINC ION, ALPHA-L-RHAMNOSE, ...
Authors:Shaya, D., Cygler, M.
Deposit date:2008-08-19
Release date:2008-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
J.Biol.Chem., 285, 2010
4LTO
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BACTERIAL SODIUM CHANNEL IN HIGH CALCIUM, I222 SPACE GROUP
Descriptor:Ion transport protein, CALCIUM ION, NICKEL (II) ION
Authors:Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., Minor, D.L.
Deposit date:2013-07-23
Release date:2013-10-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
J.Mol.Biol., 426, 2014
4LTP
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BACTERIAL SODIUM CHANNEL IN HIGH CALCIUM, I222 SPACE GROUP, CRYSTAL 2
Descriptor:Ion transport protein, CALCIUM ION
Authors:Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., Minor, D.L.
Deposit date:2013-07-23
Release date:2013-10-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
J.Mol.Biol., 426, 2014
4LTQ
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BACTERIAL SODIUM CHANNEL IN LOW CALCIUM, P42 SPACE GROUP
Descriptor:Ion transport protein
Authors:Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., Minor, D.L.
Deposit date:2013-07-23
Release date:2013-10-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
J.Mol.Biol., 426, 2014
4LTR
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BACTERIAL SODIUM CHANNEL, HIS245GLY MUTANT, I222 SPACE GROUP
Descriptor:Ion transport protein
Authors:Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., Minor, D.L.
Deposit date:2013-07-23
Release date:2013-10-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (5.8 Å)
Cite:Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
J.Mol.Biol., 426, 2014
5HK7
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BACTERIAL SODIUM CHANNEL PORE, 2.95 ANGSTROM RESOLUTION
Descriptor:Ion transport protein, CHLORIDE ION, 2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}ethyl heptadecanoate, ...
Authors:Shaya, D., Findeisen, F., Rohaim, A., Minor, D.L.
Deposit date:2016-01-14
Release date:2016-03-09
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
5IWN
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BACTERIAL SODIUM CHANNEL PORE DOMAIN, HIGH BROMIDE
Descriptor:Ion transport protein, BROMIDE ION
Authors:Shaya, D., Findeisen, F., Rohaim, A., Minor, D.L.
Deposit date:2016-03-22
Release date:2016-03-30
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
5IWO
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BACTERIAL SODIUM CHANNEL PORE DOMAIN, LOW BROMIDE
Descriptor:Ion transport protein, BROMIDE ION
Authors:Shaya, D., Findeisen, F., Rohaim, A., Minor, D.L.
Deposit date:2016-03-22
Release date:2016-03-30
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
2CKM
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (7 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLHEPTANE-1,7-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Brumshtein, B., Rydberg, E.H., Greenblatt, H.M., Wong, D.M., Shaya, D., Williams, L.D., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-04-20
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
2QXZ
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PECTATE LYASE R236F FROM XANTHOMONAS CAMPESTRIS
Descriptor:pectate lyase II, PHOSPHATE ION
Authors:Garron, M.L., Shaya, D.
Deposit date:2007-08-13
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Improvement of the thermostability and activity of a pectate lyase by single amino acid substitutions, using a strategy based on melting-temperature-guided sequence alignment.
Appl.Environ.Microbiol., 74, 2008
2QY1
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PECTATE LYASE A31G/R236F FROM XANTHOMONAS CAMPESTRIS
Descriptor:Pectate lyase II, PHOSPHATE ION
Authors:Garron, M.L., Shaya, D.
Deposit date:2007-08-13
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Improvement of the thermostability and activity of a pectate lyase by single amino acid substitutions, using a strategy based on melting-temperature-guided sequence alignment.
Appl.Environ.Microbiol., 74, 2008
3IKW
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STRUCTURE OF HEPARINASE I FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:Heparin lyase I, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Garron, M.L., Cygler, M., Shaya, D.
Deposit date:2009-08-06
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural snapshots of heparin depolymerization by heparin lyase I.
J.Biol.Chem., 284, 2009
3ILR
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STRUCTURE OF HEPARINASE I FROM BACTEROIDES THETAIOTAOMICRON IN COMPLEX WITH TETRASACCHARIDE PRODUCT
Descriptor:Heparin lyase I, CALCIUM ION, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Garron, M.L., Cygler, M., Shaya, D.
Deposit date:2009-08-07
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural snapshots of heparin depolymerization by heparin lyase I.
J.Biol.Chem., 284, 2009
1ODC
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-02-15
Release date:2005-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1UT6
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION.
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE
Authors:Brumshtein, B., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-12-04
Release date:2005-04-21
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
2CMF
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (5 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLPENTANE-1,5-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Rydberg, E.H., Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-05-08
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
2QX3
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STRUCTURE OF PECTATE LYASE II FROM XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS STR. ATCC 33913
Descriptor:Pectate lyase II, PHOSPHATE ION
Authors:Garron, M.L., Shaya, D.
Deposit date:2007-08-10
Release date:2008-03-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:A seductive method to improve the thermostability and activity of an enzyme
To be Published
3IMN
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CRYSTAL STRUCTURE OF HEPARIN LYASE I FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:Heparin lyase I, SULFATE ION, CALCIUM ION
Authors:Han, Y.H., Ryu, K.S., Jeon, Y.H.
Deposit date:2009-08-10
Release date:2009-09-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural snapshots of heparin depolymerization by heparin lyase I
J.Biol.Chem., 284, 2009
3IN9
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CRYSTAL STRUCTURE OF HEPARIN LYASE I COMPLEXED WITH DISACCHARIDE HEPARIN
Descriptor:Heparin lyase I, HEPARIN DISACCHARIDE I-S, CALCIUM ION
Authors:Han, Y.H., Ryu, K.S., Kim, H.Y., Jeon, Y.H.
Deposit date:2009-08-12
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots of heparin depolymerization by heparin lyase I
J.Biol.Chem., 284, 2009
3INA
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CRYSTAL STRUCTURE OF HEPARIN LYASE I H151A MUTANT COMPLEXED WITH A DODECASACCHARIDE HEPARIN
Descriptor:Heparin lyase I, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Han, Y.H., Ryu, K.S., Kim, H.Y., Jeon, Y.H.
Deposit date:2009-08-12
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots of heparin depolymerization by heparin lyase I
J.Biol.Chem., 284, 2009
5HJ8
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BACTERIAL SODIUM CHANNEL NECK 3G MUTANT
Descriptor:Ion transport protein, CALCIUM ION
Authors:Rohaim, A., Minor, D.L.
Deposit date:2016-01-13
Release date:2016-03-09
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
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