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5KBZ
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STRUCTURE OF THE PKSA PRODUCT TEMPLATE DOMAIN IN COMPLEX WITH A PHOSPHOPANTETHEINE MIMETIC
Descriptor:Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate
Authors:Tsai, S.C., Burkart, M.D., Townsend, C.A., Barajas, J.F., Shakya, G., Topper, C.L., Moreno, G., Jackson, D.R., Rivera, H., La Clair, J.J., Vagstad, A.
Deposit date:2016-06-03
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3QRW
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ACTINORHODIN POLYKETIDE KETOREDUCTASE MUTANT P94L BOUND TO NADPH
Descriptor:ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FORMIC ACID
Authors:Korman, T.P., Javidpour, P., Tsai, S.-C.
Deposit date:2011-02-18
Release date:2011-05-25
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011
3RI3
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ACTINORHODIN POLYKETIDE KETOREDUCTASE MUTANT P94L BOUND TO NADPH AND THE INHIBITOR EMODIN
Descriptor:ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2011-04-12
Release date:2011-06-29
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011