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8B42
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BU of 8b42 by Molmil
Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel.
Descriptor: Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8BEN
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BU of 8ben by Molmil
LRR domain Structure of the LRRC8C protein
Descriptor: Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-10-21
Release date:2022-12-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
6RTF
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BU of 6rtf by Molmil
Structure of murine Solute Carrier 26 family member A9 (Slc26a9) anion transporter in an intermediate state
Descriptor: Solute carrier family 26 member 9,Solute carrier family 26 member 9
Authors:Sawicka, M, Walter, J.D, Dutzler, R.
Deposit date:2019-05-23
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7.77 Å)
Cite:Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
Elife, 8, 2019
6RTC
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BU of 6rtc by Molmil
Structure of murine Solute Carrier 26 family member A9 (Slc26a9) anion transporter in the inward-facing state
Descriptor: Solute carrier family 26 member 9,Solute carrier family 26 member 9
Authors:Sawicka, M, Walter, J.D, Dutzler, R.
Deposit date:2019-05-23
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
Elife, 8, 2019
6G9O
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BU of 6g9o by Molmil
Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-11
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
6G8Z
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BU of 6g8z by Molmil
Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-10
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
6G9L
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BU of 6g9l by Molmil
Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-04-11
Release date:2018-05-16
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.01 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
6YTO
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BU of 6yto by Molmil
Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+
Descriptor: Calcium homeostasis modulator protein 4
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
6YTQ
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BU of 6ytq by Molmil
Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+
Descriptor: Calcium homeostasis modulator protein 4
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
6YTK
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BU of 6ytk by Molmil
Cryo-EM structure of a dimer of decameric human CALHM4 in the absence of Ca2+
Descriptor: Calcium homeostasis modulator protein 4
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
6YTX
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BU of 6ytx by Molmil
Cryo-EM structure of undecameric human CALHM6 in the presence of Ca2+
Descriptor: Calcium homeostasis modulator protein 6
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (6.23 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
6YTL
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BU of 6ytl by Molmil
Cryo-EM structure of a dimer of undecameric human CALHM4 in the absence of Ca2+
Descriptor: Calcium homeostasis modulator protein 4
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
6YTV
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BU of 6ytv by Molmil
Cryo-EM structure of decameric human CALHM6 in the presence of Ca2+
Descriptor: Calcium homeostasis modulator protein 6
Authors:Sawicka, M, Drozdzyk, K, Dutzler, R.
Deposit date:2020-04-24
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4.39 Å)
Cite:Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Elife, 9, 2020
8B40
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BU of 8b40 by Molmil
Structure of homomeric LRRC8C Volume-Regulated Anion Channel
Descriptor: Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8B41
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BU of 8b41 by Molmil
Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1
Descriptor: Synthetic nanobody Sb1, Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
Authors:Sawicka, M, Dutzler, R.
Deposit date:2022-09-19
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of a volume-regulated heteromeric LRRC8A/C channel.
Nat.Struct.Mol.Biol., 30, 2023
8OPQ
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BU of 8opq by Molmil
Structure of Human Solute Carrier 26 family member A6 (SLC26A6) anion transporter in an inward-facing state
Descriptor: CHLORIDE ION, Solute carrier family 26 member 6
Authors:Tippett, D.N, Breen, C, Butler, S.J, Sawicka, M, Dutzler, R.
Deposit date:2023-04-07
Release date:2023-05-17
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange.
Elife, 12, 2023
6FNW
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BU of 6fnw by Molmil
Structure of a volume-regulated anion channel of the LRRC8 family
Descriptor: 1,2-ETHANEDIOL, Volume-regulated anion channel subunit LRRC8A
Authors:Deneka, D, Sawicka, M, Lam, A.K.M, Paulino, C, Dutzler, R.
Deposit date:2018-02-05
Release date:2018-05-16
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a volume-regulated anion channel of the LRRC8 family.
Nature, 558, 2018
7P16
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BU of 7p16 by Molmil
Structure of caspase-3 cleaved rXKR9 in complex with a sybody at 4.3A
Descriptor: DIUNDECYL PHOSPHATIDYL CHOLINE, Sybody, XK-related protein
Authors:Straub, M.S, Sawicka, M, Dutzler, R.
Deposit date:2021-07-01
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structures of the caspase activated protein XKR9 involved in apoptotic lipid scrambling.
Elife, 10, 2021
7P14
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BU of 7p14 by Molmil
Structure of full-length rXKR9 in complex with a sybody at 3.66A
Descriptor: DIUNDECYL PHOSPHATIDYL CHOLINE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sybody, ...
Authors:Straub, M.S, Sawicka, M, Dutzler, R.
Deposit date:2021-07-01
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Cryo-EM structures of the caspase activated protein XKR9 involved in apoptotic lipid scrambling.
Elife, 10, 2021
7P5M
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BU of 7p5m by Molmil
Cryo-EM structure of human TTYH2 in lipid nanodiscs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2
Authors:Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
Deposit date:2021-07-14
Release date:2021-08-11
Last modified:2021-09-08
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P5C
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BU of 7p5c by Molmil
Cryo-EM structure of human TTYH3 in Ca2+ and GDN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 3
Authors:Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
Deposit date:2021-07-14
Release date:2021-08-11
Last modified:2021-09-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P54
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BU of 7p54 by Molmil
Cryo-EM structure of human TTYH2 in GDN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2
Authors:Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
Deposit date:2021-07-14
Release date:2021-08-11
Last modified:2021-09-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P5J
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BU of 7p5j by Molmil
Cryo-EM structure of human TTYH1 in GDN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 1
Authors:Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R.
Deposit date:2021-07-14
Release date:2021-08-11
Last modified:2021-09-08
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Nat Commun, 12, 2021
7P60
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BU of 7p60 by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio
Descriptor: Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb4
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021
7P5V
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BU of 7p5v by Molmil
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1
Descriptor: Synthetic nanobody Sb1, Volume-regulated anion channel subunit LRRC8A
Authors:Deneka, D, Rutz, S, Sawicka, M.
Deposit date:2021-07-15
Release date:2021-09-15
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
Nat Commun, 12, 2021

 

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