Author results

3KHF
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THE CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE/THREONINE KINASE 3 (MAST3)
Descriptor:Microtubule-associated serine/threonine-protein kinase 3, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Roos, A., Elkins, J., Savitsky, P., Wang, J., Ugochukwu, E., Murray, J., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-10-30
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3)
To be Published
2WNS
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HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE) DOMAIN OF URIDINE 5' -MONOPHOSPHATE SYNTHASE (UMPS) IN COMPLEX WITH ITS SUBSTRATE OROTIDINE 5'-MONOPHOSPHATE (OMP)
Descriptor:OROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION
Authors:Moche, M., Roos, A., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotyenova, T., Kotzch, A., Nielsen, T.K., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., VanDenBerg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P.
Deposit date:2009-07-19
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp)
To be Published
3HNG
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CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITH N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDE
Descriptor:Vascular endothelial growth factor receptor 1, N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, CHLORIDE ION
Authors:Tresaugues, L., Roos, A., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Kragh-Nielsen, T., Kotzch, A., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van der Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-05-31
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
2I6Q
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COMPLEMENT COMPONENT C2A
Descriptor:Complement C2a fragment, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Milder, F.J., Raaijmakers, H.C.A., Vandeputte, D.A.A., Schouten, A., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Deposit date:2006-08-29
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
2I6S
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COMPLEMENT COMPONENT C2A
Descriptor:Complement C2a fragment, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Milder, F.J., Raaijmakers, H.C.A., Vandeputte, D.A.A., Schouten, A., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Deposit date:2006-08-29
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
2OK5
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HUMAN COMPLEMENT FACTOR B
Descriptor:Complement factor B, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Milder, F.J., Gomes, L., Schouten, A., Janssen, B.J.C., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Deposit date:2007-01-16
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Factor B structure provides insights into activation of the central protease of the complement system.
Nat.Struct.Mol.Biol., 14, 2007
2VRE
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CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3,5,DELTA2,4-DIENOYL COA ISOMERASE
Descriptor:DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, CHLORIDE ION
Authors:Yue, W., Guo, K., von Delft, F., Pilka, E., Murray, J., Roos, A., Kochan, G., Bountra, C., Arrowsmith, C., Wikstrom, M., Edwards, A., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Peroxisomal Delta3,5, Delta2,4-Dienoyl Coa Isomerase (Ech1)
To be Published
2VSP
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CRYSTAL STRUCTURE OF THE FOURTH PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN 1
Descriptor:PDZ DOMAIN-CONTAINING PROTEIN 1
Authors:Yue, W.W., Shafqat, N., Pilka, E.S., Johansson, C., Murray, J.W., Elkins, J., Roos, A., Cooper, C., Phillips, C., Salah, E., von Delft, F., Doyle, D., Edwards, A., Wikstrom, M., Arrowsmith, C., Bountra, C., Oppermann, U.
Deposit date:2008-04-28
Release date:2009-03-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of the Fourth Pdz Domain of Pdz Domain-Containing Protein 1
To be Published
2VSV
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2VSW
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THE STRUCTURE OF THE RHODANESE DOMAIN OF THE HUMAN DUAL SPECIFICITY PHOSPHATASE 16
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
Authors:Murray, J.W., Barr, A., Pike, A.C.W., Elkins, J., Phillips, C., Wang, J., Savitsky, P., Roos, A., Bishop, S., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Burgess-Brown, N., Pantic, N., Bray, J., von Delft, F., Gileadi, O., Knapp, S.
Deposit date:2008-04-30
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Rhodanese Domain of the Human Dual Specifity Phosphatase 16
To be Published
2W0I
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STRUCTURE OF C-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2
Descriptor:TWINFILIN-2
Authors:Elkins, J.M., Pike, A.C.W., Salah, E., Savitsky, P., Murray, J.W., Roos, A., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstrom, M., Bountra, C., Knapp, S.
Deposit date:2008-08-18
Release date:2008-09-30
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2
To be Published
2W4M
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THE CRYSTAL STRUCTURE OF HUMAN N-ACETYLNEURAMINIC ACID PHOSPHATASE, NANP
Descriptor:N-ACYLNEURAMINATE-9-PHOSPHATASE, SODIUM ION, CHLORIDE ION, ...
Authors:Ugochukwu, E., Cocking, R., Yue, W.W., Pike, A.C.W., Roos, A., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2008-11-28
Release date:2008-12-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structure of Human N-Acetylneuraminic Acid Phosphatase, Nanp
To be Published
2X7F
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK- INTERACTING KINASE WITH WEE1CHK1 INHIBITOR
Descriptor:TRAF2 AND NCK-INTERACTING PROTEIN KINASE, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION
Authors:Vollmar, M., Alfano, I., Shrestha, B., Bray, J., Muniz, J.R.C., Roos, A., Filippakopoulos, P., Burgess-Brown, N., Ugochukwu, E., Gileadi, O., Phillips, C., Mahajan, P., Pike, A.C.W., Fedorov, O., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor
To be Published
3GP0
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CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 11 (P38 BETA) IN COMPLEX WITH NILOTINIB
Descriptor:Mitogen-activated protein kinase 11, Nilotinib, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Barr, A., Fedorov, O., Keates, T., Soundararajan, M., Elkins, J., Salah, E., Burgess-Brown, N., Ugochukwu, E., Pike, A.C.W., Muniz, J., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-03-20
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib
To be Published
3I3N
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CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMAN KLHL11
Descriptor:Kelch-like protein 11, THIOCYANATE ION, CHLORIDE ION
Authors:Murray, J.W., Cooper, C.D.O., Krojer, T., Mahajan, P., Salah, E., Keates, T., Savitsky, P., Pike, A.C.W., Roos, A., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the BTB-BACK domains of human KLHL11
To be Published
3PS4
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PDZ DOMAIN FROM HUMAN MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 1
Descriptor:Microtubule-associated serine/threonine-protein kinase 1, 1,2-ETHANEDIOL, IMIDAZOLE
Authors:Ugochukwu, E., Wang, J., Krojer, T., Muniz, J.R.C., Sethi, R., Pike, A.C.W., Roos, A., Salah, E., Cocking, R., Savitsky, P., Doyle, D.A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Elkins, J.M., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:PDZ domain from Human microtubule-associated serine/threonine-protein kinase 1
TO BE PUBLISHED
3FLV
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THE CRYSTAL STRUCTURE OF HUMAN ACYL-COENZYMEA BINDING DOMAIN CONTAINING 5
Descriptor:Acyl-CoA-binding domain-containing protein 5, STEARIC ACID, COENZYME A, ...
Authors:Ugochukwu, E., Roos, A., Yue, W.W., Shafqat, N., Salah, E., Savitsky, P., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-12-19
Release date:2009-02-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of human acyl-Coenzyme A binding domain containing 5
To be Published
4DIQ
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CRYSTAL STRUCTURE OF HUMAN NO66
Descriptor:Lysine-specific demethylase NO66, NICKEL (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Vollmar, M., Krojer, T., Ng, S., Pilka, E., Bray, J., Pike, A.C.W., Filippakopoulos, P., Roos, A., Arrowsmith, C.H., Edwards, E., Bountra, C., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2012-01-31
Release date:2012-03-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of human NO66
TO BE PUBLISHED
1V8O
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CRYSTAL STRUCTURE OF PAE2754 FROM PYROBACULUM AEROPHILUM
Descriptor:hypothetical protein PAE2754, CHLORIDE ION
Authors:Arcus, V.L., Backbro, K., Roos, A., Daniel, E.L., Baker, E.N.
Deposit date:2004-01-12
Release date:2004-02-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease
J.Biol.Chem., 279, 2004
1V8P
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CRYSTAL STRUCTURE OF PAE2754 FROM PYROBACULUM AEROPHILUM
Descriptor:hypothetical protein PAE2754, CHLORIDE ION
Authors:Arcus, V.L., Backbro, K., Roos, A., Daniel, E.L., Baker, E.N.
Deposit date:2004-01-12
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease
J.Biol.Chem., 279, 2004
2A73
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HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement C3, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A74
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HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Complement Component C3c, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, GLYCEROL, ...
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2BOD
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CATALYTIC DOMAIN OF ENDO-1,4-GLUCANASE CEL6A FROM THERMOBIFIDA FUSCA IN COMPLEX WITH METHYL CELLOBIOSYL-4-THIO-BETA-CELLOBIOSIDE
Descriptor:ENDOGLUCANASE E-2, O1-METHYL-GLUCOSE, 4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE, ...
Authors:Larsson, A.M., Bergfors, T., Dultz, E., Irwin, D.C., Roos, A., Driguez, H., Wilson, D.B., Jones, T.A.
Deposit date:2005-04-10
Release date:2005-10-05
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Thermobifida Fusca Endoglucanase Cel6A in Complex with Substrate and Inhibitor: The Role of Tyrosine Y73 in Substrate Ring Distortion.
Biochemistry, 44, 2005
2BOE
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CATALYTIC DOMAIN OF ENDO-1,4-GLUCANASE CEL6A MUTANT Y73S FROM THERMOBIFIDA FUSCA
Descriptor:ENDOGLUCANASE E-2
Authors:Larsson, A.M., Bergfors, T., Dultz, E., Irwin, D.C., Roos, A., Driguez, H., Wilson, D.B., Jones, T.A.
Deposit date:2005-04-10
Release date:2005-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal Structure of Thermobifida Fusca Endoglucanase Cel6A in Complex with Substrate and Inhibitor: The Role of Tyrosine Y73 in Substrate Ring Distortion.
Biochemistry, 44, 2005
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