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1HSM
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THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Descriptor:HIGH MOBILITY GROUP PROTEIN 1, BETA-MERCAPTOETHANOL
Authors:Read, C.M., Cary, P.D., Crane-Robinson, C., Driscoll, P.C., Carillo, M.O.M., Norman, D.G.
Deposit date:1994-11-17
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of the Hmg Box and its Interaction with DNA
To be Published
1HSN
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THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Descriptor:HIGH MOBILITY GROUP PROTEIN 1, BETA-MERCAPTOETHANOL
Authors:Read, C.M., Cary, P.D., Crane-Robinson, C., Driscoll, P.C., Carillo, M.O.M., Norman, D.G.
Deposit date:1994-11-17
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of the Hmg Box and its Interaction with DNA
To be Published
1NHM
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THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Descriptor:HIGH MOBILITY GROUP PROTEIN 1
Authors:Read, C.M., Cary, P.D., Crane-Robinson, C., Driscoll, P.C., Carillo, M.O.M., Norman, D.G.
Deposit date:1994-11-17
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of the Hmg Box and its Interaction with DNA
NUCLEIC ACIDS MOL.BIOL., 9, 1995
1NHN
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THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Descriptor:HIGH MOBILITY GROUP PROTEIN 1
Authors:Read, C.M., Cary, P.D., Crane-Robinson, C., Driscoll, P.C., Carillo, M.O.M., Norman, D.G.
Deposit date:1994-11-17
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of the Hmg Box and its Interaction with DNA
NUCLEIC ACIDS MOL.BIOL., 9, 1995
1V92
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SOLUTION STRUCTURE OF THE UBA DOMAIN FROM P47, A MAJOR COFACTOR OF THE AAA ATPASE P97
Descriptor:NSFL1 cofactor p47
Authors:Yuan, X., Simpson, P., Mckeown, C., Kondo, H., Uchiyama, K., Wallis, R., Dreveny, I., Keetch, C., Zhang, X., Robinson, C., Freemont, P., Matthews, S.
Deposit date:2004-01-19
Release date:2004-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97
Embo J., 23, 2004
1VAZ
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SOLUTION STRUCTURES OF THE P47 SEP DOMAIN
Descriptor:NSFL1 cofactor p47
Authors:Yuan, X., Simpson, P., Mckeown, C., Kondo, H., Uchiyama, K., Wallis, R., Dreveny, I., Keetch, C., Zhang, X., Robinson, C., Freemont, P., Matthews, S.
Deposit date:2004-02-20
Release date:2004-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97.
Embo J., 23, 2004
2VRD
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THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C, ZINC ION
Authors:Muto, Y., Pomeranz-Krummel, D., Oubridge, C., Hernandez, H., Robinson, C., Neuhaus, D., Nagai, K.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure and Biochemical Properties of the Human Spliceosomal Protein U1C
J.Mol.Biol., 341, 2004
1I11
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SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN, SOX-5 HMG BOX FROM MOUSE
Descriptor:TRANSCRIPTION FACTOR SOX-5
Authors:Cary, P.D., Read, C.M., Davis, B., Driscoll, P.C., Crane-Robinson, C.
Deposit date:2001-01-30
Release date:2001-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the DNA-binding domain of mouse Sox-5.
Protein Sci., 10, 2001
4M0Y
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 1 [4-(CARBAMOYLAMINO)-1-(NAPHTHALEN-1-YL)-1H-PYRAZOLE-3-CARBOXAMIDE]
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-(naphthalen-1-yl)-1H-pyrazole-3-carboxamide
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
4M0Z
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 5 {4-(CARBAMOYLAMINO)-1-(7-METHOXYNAPHTHALEN-1-YL)-1H-PYRAZOLE-3-CARBOXAMIDE}
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
4M12
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 7 [4-(CARBAMOYLAMINO)-1-(7-ETHOXYNAPHTHALEN-1-YL)-1H-PYRAZOLE-3-CARBOXAMIDE]
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
4M13
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 8 [4-(CARBAMOYLAMINO)-1-(7-PROPOXYNAPHTHALEN-1-YL)-1H-PYRAZOLE-3-CARBOXAMIDE]
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-(7-propoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
4M14
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 9 [4-(CARBAMOYLAMINO)-1-[7-(PROPAN-2-YLOXY)NAPHTHALEN-1-YL]-1H-PYRAZOLE-3-CARBOXAMIDE]
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
4M15
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CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 9 [4-(CARBAMOYLAMINO)-1-[7-(PROPAN-2-YLOXY)NAPHTHALEN-1-YL]-1H-PYRAZOLE-3-CARBOXAMIDE] AND ADP
Descriptor:Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE
Authors:Han, S., Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
2JL4
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HOLO STRUCTURE OF MALEYL PYRUVATE ISOMERASE, A BACTERIAL GLUTATHIONE- S-TRANSFERASE IN ZETA CLASS
Descriptor:MALEYLPYRUVATE ISOMERASE, GLUTATHIONE
Authors:Shoemark, D.K., Y Zhou, N., Williams, P.A., Hadfield, A.T.
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation.
J.Mol.Biol., 384, 2008
2V6K
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STRUCTURE OF MALEYL PYRUVATE ISOMERASE, A BACTERIAL GLUTATHIONE-S- TRANSFERASE IN ZETA CLASS, IN COMPLEX WITH SUBSTRATE ANALOGUE DICARBOXYETHYL GLUTATHIONE
Descriptor:MALEYLPYRUVATE ISOMERASE, GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE, SODIUM ION, ...
Authors:Shoemark, D.K., Zhou, N.-Y., Williams, P.A., Hadfield, A.T.
Deposit date:2007-07-19
Release date:2008-07-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation.
J.Mol.Biol., 384, 2008
3DEO
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STRUCTURAL BASIS FOR SPECIFIC SUBSTRATE RECOGNITION BY THE CHLOROPLAST SIGNAL RECOGNITION PARTICLE PROTEIN CPSRP43
Descriptor:Signal recognition particle 43 kDa protein, MAGNESIUM ION
Authors:Stengel, K.F., Wild, K., Sinning, I.
Deposit date:2008-06-10
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43.
Science, 321, 2008
3DEP
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STRUCTURAL BASIS FOR SPECIFIC SUBSTRATE RECOGNITION BY THE CHLOROPLAST SIGNAL RECOGNITION PARTICLE PROTEIN CPSRP43
Descriptor:Signal recognition particle 43 kDa protein, YPGGSFDPLGLA, CHLORIDE ION
Authors:Holdermann, I., Stengel, K.F., Wild, K., Sinning, I.
Deposit date:2008-06-10
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43.
Science, 321, 2008
3WTD
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STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Ochi, T., Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
Science, 347, 2015
3WTF
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STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Ochi, T., Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Method:X-RAY DIFFRACTION (3.451 Å)
Cite:PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
Science, 347, 2015
5JFS
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-00593174
Descriptor:High affinity nerve growth factor receptor, N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea
Authors:Jayasankar, J., Brown, D., Skerratt, S., Kurumbail, R.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFV
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05206283
Descriptor:High affinity nerve growth factor receptor, N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide
Authors:Jayasankar, J., Kurumbail, R., Brown, D., Skerratt, S.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFW
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05247452
Descriptor:High affinity nerve growth factor receptor, 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide
Authors:Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFX
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-06273340
Descriptor:High affinity nerve growth factor receptor, N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide
Authors:Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016