7NRI

Structure of the darobactin-bound E. coli BAM complex (BamABCDE)

Summary for 7NRI

• Entry DOI: 10.2210/pdb7nri/pdb
• EMDB information: 12546
• Related PRD ID: PRD_002330
• Descriptor: Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... (6 entities in total)
• Functional Keywords: beta-barrel, outer membrane, protein insertion, protein folding, protein maturation, antibiotic, natural product, cyclized peptide, membrane protein
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 6
• Total formula weight: 201803.83

Authors

Jakob, R.P.,Kaur, H.,Marzinek, J.K.,Green, R.,Imai, Y.,Bolla, J.,Robinson, C.,Bond, P.J.,Lewis, K.,Maier, T.,Hiller, S. (deposition date: 2021-03-03, release date: 2021-04-21, Last modification date: 2021-05-19)

• Primary citation: Kaur, H.,Jakob, R.P.,Marzinek, J.K.,Green, R.,Imai, Y.,Bolla, J.R.,Agustoni, E.,Robinson, C.V.,Bond, P.J.,Lewis, K.,Maier, T.,Hiller, S.; The antibiotic darobactin mimics a beta-strand to inhibit outer membrane insertase.; Nature, 593:125-129, 2021; PubMed: 33854236; DOI: 10.1038/s41586-021-03455-w

Experimental method

ELECTRON MICROSCOPY (3.03 Å)