Author results

5VJH
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CLOSED STATE CRYOEM RECONSTRUCTION OF HSP104:ATPYS AND FITC CASEIN
Descriptor:Heat shock protein 104, FITC casein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Gates, S.N., Yokom, A.L., Lin, J.-B., Jackrel, M.E., Rizo, A.N., Kendsersky, N.M., Buell, C.E., Sweeny, E.A., Chuang, E., Torrente, M.P., Mack, K.L., Su, M., Shorter, J., Southworth, D.R.
Deposit date:2017-04-19
Release date:2017-07-05
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Science, 357, 2017
5VY8
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S. CEREVISIAE HSP104-ADP COMPLEX
Descriptor:Heat shock protein 104, ADENOSINE-5'-DIPHOSPHATE
Authors:Gates, S.N., Yokom, A.L., Lin, J.-B., Jackrel, M.E., Rizo, A.N., Kendsersky, N.M., Buell, C.E., Sweeny, E.A., Chuang, E., Torrente, M.P., Mack, K.L., Su, M., Shorter, J., Southworth, D.R.
Deposit date:2017-05-24
Release date:2017-07-05
Last modified:2018-08-15
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Science, 357, 2017
5VY9
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S. CEREVISIAE HSP104:CASEIN COMPLEX, MIDDLE DOMAIN CONFORMATION
Descriptor:Heat shock protein 104, Alpha-S1-casein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Gates, S.N., Yokom, A.L., Lin, J.-B., Jackrel, M.E., Rizo, A.N., Kendsersky, N.M., Buell, C.E., Sweeny, E.A., Chuang, E., Torrente, M.P., Mack, K.L., Su, M., Shorter, J., Southworth, D.R.
Deposit date:2017-05-24
Release date:2017-07-19
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Science, 357, 2017
5VYA
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S. CEREVISIAE HSP104:CASEIN COMPLEX, EXTENDED CONFORMATION
Descriptor:Heat shock protein 104, Alpha-S1-casein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Gates, S.N., Yokom, A.L., Lin, J.-B., Jackrel, M.E., Rizo, A.N., Kendsersky, N.M., Buell, C.E., Sweeny, E.A., Chuang, E., Torrente, M.P., Mack, K.L., Su, M., Shorter, J., Southworth, D.R.
Deposit date:2017-05-24
Release date:2017-07-05
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Science, 357, 2017
6UQO
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CLPA/CLPP ENGAGED STATE BOUND TO REPA-GFP
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp endopeptidase proteolytic subunit ClpP, RepA-GFP, ...
Authors:Lopez, K.L., Rizo, A.N., Southworth, D.R.
Deposit date:2019-10-21
Release date:2020-04-22
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W1Z
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CLPAP ENGAGED1 STATE BOUND TO REPA-GFP
Descriptor:ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W20
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CLPAP DISENGAGED STATE BOUND TO REPA-GFP
Descriptor:ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W21
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CLPAP ENGAGED2 STATE BOUND TO REPA-GFP
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, green fluorescent protein fusion, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W22
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CLPA ENGAGED1 STATE BOUND TO REPA-GFP (CLPA FOCUSED REFINEMENT)
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, green fluorescent protein fusion, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-04-29
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W23
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CLPA DISENGAGED STATE BOUND TO REPA-GFP (FOCUSED CLASSIFICATION)
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, green fluorescent protein fusion, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W24
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CLPA ENGAGED2 STATE BOUND TO REPA-GFP (FOCUSED CLASSIFICATION)
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, RepA, green fluorescent protein fusion, ...
Authors:Lopez, K.L., Rizo, A.N., Tse, E., Lin, J., Scull, N.W., Thwin, A.C., Lucius, A.L., Shorter, J., Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
7KKJ
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STRUCTURE OF ANTI-SARS-COV-2 SPIKE NANOBODY MNB6
Descriptor:Synthetic nanobody mNb6, SULFATE ION, CHLORIDE ION
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKK
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY NB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody Nb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKL
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY MNB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody mNb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
6OAX
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STRUCTURE OF THE HYPERACTIVE CLPB MUTANT K476C, BOUND TO CASEIN, PRE-STATE
Descriptor:Hyperactive disaggregase ClpB, Alpha-S1-casein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Rizo, A.R., Lin, J.-B., Gates, S.N., Tse, E., Bart, S.M., Castellano, L.M., Dimaio, F., Shorter, J., Southworth, D.R.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OAY
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STRUCTURE OF THE HYPERACTIVE CLPB MUTANT K476C, BOUND TO CASEIN, POST-STATE
Descriptor:Hyperactive disaggregase ClpB, Alpha-S1-casein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Rizo, A.R., Lin, J.-B., Gates, S.N., Tse, E., Bart, S.M., Castellano, L.M., Dimaio, F., Shorter, J., Southworth, D.R.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OG1
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FOCUS CLASSIFICATION STRUCTURE OF THE HYPERACTIVE CLPB MUTANT K476C, BOUND TO CASEIN, PRE-STATE
Descriptor:Hyperactive disaggregase ClpB, ADENOSINE-5'-DIPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Rizo, A.R., Lin, J.-B., Gates, S.N., Tse, E., Bart, S.M., Castellano, L.M., Dimaio, F., Shorter, J., Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OG2
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FOCUS CLASSIFICATION STRUCTURE OF THE HYPERACTIVE CLPB MUTANT K476C, BOUND TO CASEIN, POST-STATE
Descriptor:Hyperactive disaggregase ClpB, ADENOSINE-5'-DIPHOSPHATE
Authors:Rizo, A.R., Lin, J.-B., Gates, S.N., Tse, E., Bart, S.M., Castellano, L.M., Dimaio, F., Shorter, J., Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OG3
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FOCUS CLASSIFICATION STRUCTURE OF THE HYPERACTIVE CLPB MUTANT K476C, BOUND TO CASEIN, NTD-TRIMER
Descriptor:Hyperactive disaggregase ClpB, Alpha S1-casein
Authors:Rizo, A.R., Lin, J.-B., Gates, S.N., Tse, E., Bart, S.M., Castellano, L.M., Dimaio, F., Shorter, J., Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6UQE
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CLPA/CLPP DISENGAGED STATE BOUND TO REPA-GFP
Descriptor:ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease proteolytic subunit, RepA-GFP, ...
Authors:Lopez, K.L., Rizo, A.R., Southworth, D.R.
Deposit date:2019-10-18
Release date:2020-04-22
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
7KDT
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HUMAN TOM70 IN COMPLEX WITH SARS COV2 ORF9B
Descriptor:Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Last modified:2020-11-04
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 2020
171588
PDB entries from 2020-11-25