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5U2M
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1293201
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, SULFATE ION
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5U2N
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1326133
分子名称:Nicotinamide phosphoribosyltransferase, SULFATE ION, N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5UPE
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 5
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(3-phenylpropyl)carbamoyl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
5UPF
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 53
分子名称:Nicotinamide phosphoribosyltransferase, 5-fluoro-N-{4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
5WI0
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH FRAGMENT 2: 2-[(2-FLUOROPHENYL)AMINO]-6-PROPYLPYRIMIDIN-4(3H)-ONE
分子名称:Nicotinamide phosphoribosyltransferase, 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-07-18
公開日2018-01-10
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Fragment-based discovery of a potent NAMPT inhibitor.
Bioorg. Med. Chem. Lett., 28, 2018
5WI1
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH FRAGMENT 5: (3E)-3-[(PHENYLAMINO)METHYLIDENE]OXAN-2-ONE
分子名称:Nicotinamide phosphoribosyltransferase, (3E)-3-[(phenylamino)methylidene]oxan-2-one, SULFATE ION
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-07-18
公開日2018-01-10
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Fragment-based discovery of a potent NAMPT inhibitor.
Bioorg. Med. Chem. Lett., 28, 2018