5WI1

Crystal structure of human NAMPT with fragment 5: (3E)-3-[(phenylamino)methylidene]oxan-2-one

Summary for 5WI1

• Entry DOI: 10.2210/pdb5wi1/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, (3E)-3-[(phenylamino)methylidene]oxan-2-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: nampt, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 111788.48

Authors

Longenecker, K.L.,Raich, D.,Korepanova, A.V. (deposition date: 2017-07-18, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Korepanova, A.,Longenecker, K.L.,Pratt, S.D.,Panchal, S.C.,Clark, R.F.,Lake, M.,Gopalakrishnan, S.M.,Raich, D.,Sun, C.,Petros, A.M.; Fragment-based discovery of a potent NAMPT inhibitor.; Bioorg. Med. Chem. Lett., 28:437-440, 2018; PubMed: 29287958; DOI: 10.1016/j.bmcl.2017.12.023

Experimental method

X-RAY DIFFRACTION (1.99 Å)