Author results

1MM4
  • Download 1mm4
  • View 1mm4
Molmil generated image of 1mm4
SOLUTION NMR STRUCTURE OF THE OUTER MEMBRANE ENZYME PAGP IN DPC MICELLES
Descriptor:CrcA protein
Authors:Hwang, P.M., Choy, W.-Y., Lo, E.I., Chen, L., Forman-Kay, J.D., Raetz, C.R.H., Prive, G.G., Bishop, R.E., Kay, L.E.
Deposit date:2002-09-03
Release date:2002-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
1MM5
  • Download 1mm5
  • View 1mm5
Molmil generated image of 1mm5
SOLUTION NMR STRUCTURE OF THE OUTER MEMBRANE ENZYME PAGP IN OG MICELLES
Descriptor:CrcA protein
Authors:Hwang, P.M., Choy, W.-Y., Lo, E.I., Chen, L., Forman-Kay, J.D., Raetz, C.R.H., Prive, G.G., Bishop, R.E., Kay, L.E.
Deposit date:2002-09-03
Release date:2002-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
Proc.Natl.Acad.Sci.USA, 99, 2002
1XXE
  • Download 1xxe
  • View 1xxe
Molmil generated image of 1xxe
RDC REFINED SOLUTION STRUCTURE OF THE AALPXC/TU-514 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL
Authors:Coggins, B.E., McClerren, A.L., Jiang, L., Li, X., Rudolph, J., Hindsgaul, O., Raetz, C.R.H., Zhou, P.
Deposit date:2004-11-04
Release date:2004-11-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design
Biochemistry, 44, 2005
1YUC
  • Download 1yuc
  • View 1yuc
Molmil generated image of 1yuc
HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO PHOSPHOLIPID AND A FRAGMENT OF HUMAN SHP
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor 0B2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Ortlund, E.A., Yoonkwang, L., Solomon, I.H., Hager, J.M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C.R.H., McDonnell, D.P., Moore, D.D., Redinbo, M.R.
Deposit date:2005-02-13
Release date:2005-03-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
Nat.Struct.Mol.Biol., 12, 2005
2BLL
  • Download 2bll
  • View 2bll
Molmil generated image of 2bll
APO-STRUCTURE OF THE C-TERMINAL DECARBOXYLASE DOMAIN OF ARNA
Descriptor:PROTEIN YFBG
Authors:Williams, G.J., Breazeale, S.D., Raetz, C.R.H., Naismith, J.H.
Deposit date:2005-03-07
Release date:2005-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L- Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
2BLN
  • Download 2bln
  • View 2bln
Molmil generated image of 2bln
N-TERMINAL FORMYLTRANSFERASE DOMAIN OF ARNA IN COMPLEX WITH N-5- FORMYLTETRAHYDROFOLATE AND UMP
Descriptor:PROTEIN YFBG, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, URIDINE-5'-MONOPHOSPHATE, ...
Authors:Williams, G.J., Breazeale, S.D., Raetz, C.R.H., Naismith, J.H.
Deposit date:2005-03-07
Release date:2005-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L-Arabinose Biosynthesis.
J.Biol.Chem., 280, 2005
2QIA
  • Download 2qia
  • View 2qia
Molmil generated image of 2qia
STRUCTURAL BASIS FOR THE ACYL CHAIN SELECTIVITY AND MECHANISM OF UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H., Raetz, C.R.H.
Deposit date:2007-07-03
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QIV
  • Download 2qiv
  • View 2qiv
Molmil generated image of 2qiv
STRUCTURAL BASIS FOR THE ACYL CHAIN SELECTIVITY AND MECHANISM OF UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H., Raetz, C.R.H.
Deposit date:2007-07-05
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
4J6E
  • Download 4j6e
  • View 4j6e
Molmil generated image of 4j6e
STRUCTURE OF LPXI D225A MUTANT
Descriptor:UDP-2,3-diacylglucosamine pyrophosphatase LpxI, (2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate
Authors:Metzger IV, L.E., Lee, J.K., Finer-Moore, J.S., Raetz, C.R.H., Stroud, R.M., Center for Structures of Membrane Proteins (CSMP)
Deposit date:2013-02-11
Release date:2013-05-08
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:LpxI structures reveal how a lipid A precursor is synthesized.
Nat.Struct.Mol.Biol., 19, 2012
3T57
  • Download 3t57
  • View 3t57
Molmil generated image of 3t57
ACTIVITY AND CRYSTAL STRUCTURE OF ARABIDOPSIS UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:UDP-N-acetylglucosamine O-acyltransferase domain-containing protein
Authors:Raetz, C.R.H., Joo, S.H.
Deposit date:2011-07-26
Release date:2012-05-23
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activity and Crystal Structure of Arabidopsis thalianaUDP-N-Acetylglucosamine Acyltransferase.
Biochemistry, 51, 2012
2JT2
  • Download 2jt2
  • View 2jt2
Molmil generated image of 2jt2
SOLUTION STRUCTURE OF THE AQUIFEX AEOLICUS LPXC- CHIR-090 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide
Authors:Barb, A.W., Jiang, L., Raetz, C.R.H., Zhou, P.
Deposit date:2007-07-18
Release date:2007-12-04
Last modified:2018-03-14
Method:SOLUTION NMR
Cite:Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
Proc.Natl.Acad.Sci.Usa, 104, 2007
3EH0
  • Download 3eh0
  • View 3eh0
Molmil generated image of 3eh0
CRYSTAL STRUCTURE OF LPXD FROM ESCHERICHIA COLI
Descriptor:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
Authors:Bartling, C.M., Raetz, C.R.H.
Deposit date:2008-09-11
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis
Biochemistry, 48, 2009
4EHW
  • Download 4ehw
  • View 4ehw
Molmil generated image of 4ehw
CRYSTAL STRUCTURE OF LPXK FROM AQUIFEX AEOLICUS AT 2.3 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, GLYCEROL, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Emptage, R.P., Daughtry, K.D., Pemble IV, C.W., Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EHX
  • Download 4ehx
  • View 4ehx
Molmil generated image of 4ehx
CRYSTAL STRUCTURE OF LPXK FROM AQUIFEX AEOLICUS AT 1.9 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Emptage, R.P., Daughtry, K.D., Pemble IV, C.W., Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EHY
  • Download 4ehy
  • View 4ehy
Molmil generated image of 4ehy
CRYSTAL STRUCTURE OF LPXK FROM AQUIFEX AEOLICUS IN COMPLEX WITH ADP/MG2+ AT 2.2 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Emptage, R.P., Daughtry, K.D., Pemble IV, C.W., Raetz, C.R.H.
Deposit date:2012-04-04
Release date:2012-08-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGM
  • Download 4ggm
  • View 4ggm
Molmil generated image of 4ggm
STRUCTURE OF LPXI
Descriptor:UDP-2,3-diacylglucosamine pyrophosphatase LpxI, MAGNESIUM ION, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE
Authors:Metzger IV, L.E., Lee, J.K., Finer-Moore, J.S., Raetz, C.R.H., Stroud, R.M., Center for Structures of Membrane Proteins (CSMP)
Deposit date:2012-08-06
Release date:2012-10-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.897 Å)
Cite:LpxI structures reveal how a lipid A precursor is synthesized.
Nat.Struct.Mol.Biol., 19, 2012
4IHF
  • Download 4ihf
  • View 4ihf
Molmil generated image of 4ihf
CHASING ACYL CARRIER PROTEIN THROUGH A CATALYTIC CYCLE OF LIPID A PRODUCTION
Descriptor:UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase, Acyl carrier protein, CHLORIDE ION, ...
Authors:Masoudi, A., Raetz, C.R.H., Pemble, C.W.
Deposit date:2012-12-18
Release date:2013-11-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature, 505, 2014
4IHG
  • Download 4ihg
  • View 4ihg
Molmil generated image of 4ihg
CHASING ACYL CARRIER PROTEIN THROUGH A CATALYTIC CYCLE OF LIPID A PRODUCTION
Descriptor:UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase, Acyl carrier protein, 3-HYDROXY-TETRADECANOIC ACID, ...
Authors:Masoudi, A., Raetz, C.R.H., Pemble, C.W.
Deposit date:2012-12-18
Release date:2013-11-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature, 505, 2014
4IHH
  • Download 4ihh
  • View 4ihh
Molmil generated image of 4ihh
CHASING ACYL CARRIER PROTEIN THROUGH A CATALYTIC CYCLE OF LIPID A PRODUCTION
Descriptor:UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase, Acyl carrier protein, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Masoudi, A., Raetz, C.R.H., Pemble, C.W.
Deposit date:2012-12-18
Release date:2013-11-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.132 Å)
Cite:Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature, 505, 2014
4ITL
  • Download 4itl
  • View 4itl
Molmil generated image of 4itl
CRYSTAL STRUCTURE OF LPXK FROM AQUIFEX AEOLICUS IN COMPLEX WITH AMP-PCP AT 2.1 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, GLYCEROL
Authors:Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.
Deposit date:2013-01-18
Release date:2013-04-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis.
Biochemistry, 52, 2013
4ITM
  • Download 4itm
  • View 4itm
Molmil generated image of 4itm
CRYSTAL STRUCTURE OF "APO" FORM LPXK FROM AQUIFEX AEOLICUS IN COMPLEX WITH ATP AT 2.2 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, ADENOSINE-5'-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.
Deposit date:2013-01-18
Release date:2013-04-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1994 Å)
Cite:Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis.
Biochemistry, 52, 2013
4ITN
  • Download 4itn
  • View 4itn
Molmil generated image of 4itn
CRYSTAL STRUCTURE OF "COMPACT P-LOOP" LPXK FROM AQUIFEX AEOLICUS IN COMPLEX WITH CHLORIDE AT 2.2 ANGSTROM RESOLUTION
Descriptor:Tetraacyldisaccharide 4'-kinase, GLYCEROL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.
Deposit date:2013-01-18
Release date:2013-04-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1912 Å)
Cite:Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis.
Biochemistry, 52, 2013
5YKA
  • Download 5yka
  • View 5yka
Molmil generated image of 5yka
CRYSTAL STRUCTURE OF THE KDO HYDROXYLASE KDOO, A NON-HEME FE(II) ALPHAKETOGLUTARATE DEPENDENT DIOXYGENASE IN COMPLEX WITH COBALT(II)
Descriptor:Uncharacterized protein KdoO, COBALT (II) ION, SULFATE ION, ...
Authors:Chung, H.S., Pemble, C.W., Joo, S.H., Raetz, C.R.
Deposit date:2017-10-12
Release date:2018-09-05
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
5YVZ
  • Download 5yvz
  • View 5yvz
Molmil generated image of 5yvz
CRYSTAL STRUCTURE OF THE KDO HYDROXYLASE KDOO, A NON-HEME FE(II) ALPHAKETOGLUTARATE DEPENDENT DIOXYGENASE IN COMPLEX WITH ALPHAKETOGLUTARATE AND FE(III)
Descriptor:Uncharacterized protein KdoO, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Chung, H.S., Pemble, C.W., Joo, S.H., Raetz, C.R.
Deposit date:2017-11-28
Release date:2018-09-05
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
5YW0
  • Download 5yw0
  • View 5yw0
Molmil generated image of 5yw0
CRYSTAL STRUCTURE OF THE KDO HYDROXYLASE KDOO, A NON-HEME FE(II) ALPHAKETOGLUTARATE DEPENDENT DIOXYGENASE IN COMPLEX WITH SUCCINATE AND FE(III)
Descriptor:Uncharacterized protein KdoO, TETRAETHYLENE GLYCOL, FE (III) ION, ...
Authors:Chung, H.S., Pemble, C.W., Joo, S.H., Raetz, C.R.
Deposit date:2017-11-28
Release date:2018-09-05
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Biochemical and Structural Insights into an Fe(II)/ alpha-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO).
J. Mol. Biol., 430, 2018
<12>