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2XVT
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN RAMP2
Descriptor:RECEPTOR ACTIVITY-MODIFYING PROTEIN 2, CALCIUM ION
Authors:Quigley, A., Pike, A.C.W., Burgess-Brown, N., Krojer, T., Shrestha, L., Goubin, S., Kim, J., Das, S., Muniz, J.R.C., Canning, P., Chaikuad, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Barr, A.J., Carpenter, E.P.
Deposit date:2010-10-31
Release date:2010-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Extracellular Domain of Human Ramp2
To be Published
2YPT
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CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 MUTANT (E336A) IN COMPLEX WITH A SYNTHETIC CSIM TETRAPEPTIDE FROM THE C-TERMINUS OF PRELAMIN A
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Savitsky, P., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-11-01
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
4AW6
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CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 (FACE1)
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-05-31
Release date:2012-07-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
2X57
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Descriptor:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Authors:Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-02-05
Release date:2010-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
2XDG
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.
Descriptor:GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-04-30
Release date:2010-06-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
3ZDU
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CRYSTAL STRUCTURE OF THE HUMAN CDKL3 KINASE DOMAIN
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 3, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ZINC ION, ...
Authors:Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Pike, A.C.W., Quigley, A., MacKenzie, A., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2012-11-30
Release date:2013-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Human Cdkl3 Kinase Domain
To be Published
4BGJ
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CRYSTAL STRUCTURE OF THE PHOX-HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 14
Descriptor:SORTING NEXIN-14
Authors:Vollmar, M., Kiyani, W., Shrestha, L., Goubin, S., Krojer, T., Pike, A.C.W., Carpenter, E., Quigley, A., McKenzie, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Yue, W.W.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of the Phox-Homology Domain of Human Sorting Nexin 14
To be Published
4TWK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK1 (K2P2.1)
Descriptor:Potassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.
Deposit date:2014-06-30
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published
5C65
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STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
4BW5
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ...
Authors:Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
4B50
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CRYSTAL STRUCTURE OF THE HIV-1 GP41 MPER-SPECIFIC LLAMA VHH 2H10
Descriptor:2H10 LLAMA VHH
Authors:Lutje Hulsik, D., Sabin, C., Macheboeuf, P., Weissenhorn, W.
Deposit date:2012-08-02
Release date:2013-03-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A Gp41 Mper-Specific Llama Vhh Requires a Hydrophobic Cdr3 for Neutralization But not for Antigen Recognition.
Plos Pathog., 9, 2013
4XDJ
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN AN ALTERNATE CONFORMATION (FORM 2)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE
Descriptor:Potassium channel subfamily K member 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDL
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH A BROMINATED FLUOXETINE DERIVATIVE.
Descriptor:Potassium channel subfamily K member 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Mackenzie, A., Pike, A.C.W., Dong, Y.Y., Mukhopadhyay, S., Ruda, G.F., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
5A6R
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN KCTD17
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD17
Authors:Pinkas, D.M., Sorrell, F., Sanvitale, C.E., Goubin, S., Williams, E., Newman, J.A., Pearce, N.M., Neshich, I., Pike, A.C.W., MacKenzie, A., Quigley, A., Faust, B., Carpenter, E.P., Tallant, C., Kopec, J., Chalk, R., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
4AYT
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYW
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYX
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
5AHO
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CRYSTAL STRUCTURE OF HUMAN 5' EXONUCLEASE APOLLO
Descriptor:5' EXONUCLEASE APOLLO, 1,2-ETHANEDIOL, L(+)-TARTARIC ACID, ...
Authors:Allerston, C.K., Vollmar, M., Krojer, T., Pike, A.C.W., Newman, J.A., Carpenter, E., Quigley, A., Mahajan, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Gileadi, O.
Deposit date:2015-02-06
Release date:2015-02-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The Structures of the Snm1A and Snm1B/Apollo Nuclease Domains Reveal a Potential Basis for Their Distinct DNA Processing Activities.
Nucleic Acids Res., 43, 2015