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2X9C
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CRYSTAL STRUCTURE OF A SOLUBLE PRGI MUTANT FROM SALMONELLA TYPHIMURIUM
Descriptor:PROTEIN PRGI
Authors:Poyraz, O., Schmidt, H., Seidel, K., Delissen, F., Ader, C., Tenenboim, H., Goosmann, C., Laube, B., Thuenemann, A.F., Zychlinsky, A., Baldus, M., Lange, A., Griesinger, C., Kolbe, M.
Deposit date:2010-03-15
Release date:2010-06-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Protein Refolding is Required for Assembly of the Type Three Secretion Needle
Nat.Struct.Mol.Biol., 17, 2010
3ZEI
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS O-ACETYLSERINE SULFHYDRYLASE (OASS) CYSK1 IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:O-ACETYLSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE, 3-[(Z)-[(5Z)-5-[[2-(2-hydroxy-2-oxoethyloxy)phenyl]methylidene]-3-methyl-4-oxidanylidene-1,3-thiazolidin-2-ylidene]amino]benzoic acid, ...
Authors:Poyraz, O., Schnell, R., Schneider, G.
Deposit date:2012-12-05
Release date:2013-08-07
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium Tuberculosis.
J.Med.Chem., 56, 2013
4BZP
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS APS KINASE CYSC IN COMPLEX WITH ADP
Descriptor:BIFUNCTIONAL ENZYME CYSN/CYSC, ADENOSINE-5'-DIPHOSPHATE, 1,2-ETHANEDIOL
Authors:Poyraz, O., Lohkamp, B., Schnell, R., Schneider, G.
Deposit date:2013-07-29
Release date:2014-08-06
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium Tuberculosis.
Plos One, 10, 2015
4BZQ
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS APS KINASE CYSC IN COMPLEX WITH ADP AND APS
Descriptor:BIFUNCTIONAL ENZYME CYSN/CYSC, ADENOSINE-5'-PHOSPHOSULFATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Poyraz, O., Schnell, R., Schneider, G.
Deposit date:2013-07-29
Release date:2014-08-13
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium Tuberculosis.
Plos One, 10, 2015
4BZX
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS APS KINASE CYSC IN COMPLEX WITH AMPPNP AND APS
Descriptor:BIFUNCTIONAL ENZYME CYSN/CYSC, ADENOSINE-5'-PHOSPHOSULFATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Poyraz, O., Lohkamp, B., Schnell, R., Schneider, G.
Deposit date:2013-07-30
Release date:2014-08-13
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium Tuberculosis.
Plos One, 10, 2015
4RFV
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS APS KINASE CYSC CYS556ALA MUTANT
Descriptor:Bifunctional enzyme CysN/CysC, PHOSPHATE ION
Authors:Poyraz, O., Brunner, K., Schnell, R., Schneider, G.
Deposit date:2014-09-28
Release date:2015-01-28
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis.
Plos One, 10, 2015
2KV7
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NMR SOLUTION STRUCTURE OF A SOLUBLE PRGI MUTANT FROM SALMONELLA TYPHIMURIUM
Descriptor:Protein prgI
Authors:Schmidt, H., Poyraz, O., Seidel, K., Delissen, F., Ader, C., Tenenboim, H., Goosmann, C., Laube, B., Thuenemann, A.F., Zychlinski, A., Baldus, M., Lange, A., Griesinger, C., Kolbe, M.
Deposit date:2010-03-09
Release date:2010-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Protein refolding is required for assembly of the type three secretion needle
Nat.Struct.Mol.Biol., 2010
5I6D
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 5 [3-(3-(P-TOLYL)UREIDO) BENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 3-{[(4-methylphenyl)carbamoyl]amino}benzoic acid, ...
Authors:Schnell, R., Maric, S., Schneider, G.
Deposit date:2016-02-16
Release date:2016-08-17
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5I7A
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 1 [3-(3-(3,4-DICHLOROPHENYL)UREIDO)BENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, 3-{[(3,4-dichlorophenyl)carbamoyl]amino}benzoic acid, PYRIDOXAL-5'-PHOSPHATE
Authors:Schnell, R., Maric, S., Schneider, G.
Deposit date:2016-02-17
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5I7H
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 6 [3-(3-(4-BROMOPHENYL)UREIDO)BENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, 3-{[(4-bromophenyl)carbamoyl]amino}benzoic acid, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Schnell, R., Maric, S., Schneider, G.
Deposit date:2016-02-17
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5I7O
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 7 [3-(3-(4-CHLOROPHENYL)UREIDO)BENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 3-{[(4-chlorophenyl)carbamoyl]amino}benzoic acid
Authors:Schnell, R., Maric, S., Schneider, G.
Deposit date:2016-02-18
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5I7R
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 2 [3-(3-([1,1'-BIPHENYL]-3-YL)UREIDO)BENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 3-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}benzoic acid, ...
Authors:Schnell, R., Maric, S., Schneider, G.
Deposit date:2016-02-18
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5IW8
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 4 [5-(3-([1,1'-BIPHENYL]-3-YL)UREIDO)-2-HYDROXYBENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, 5-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid, SODIUM ION, ...
Authors:Brunner, K., Schnell, R., Schneider, G.
Deposit date:2016-03-22
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016
5IWC
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MYCOBACTERIUM TUBERCULOSIS CYSM IN COMPLEX WITH THE UREA-SCAFFOLD INHIBITOR 3 [4-(3-([1,1'-BIPHENYL]-3-YL)UREIDO)-2-HYDROXYBENZOIC ACID]
Descriptor:O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 4-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid
Authors:Schnell, R., Maric, S., Lindqvist, Y., Schneider, G.
Deposit date:2016-03-22
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
J.Med.Chem., 59, 2016