5I6D

Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 5 [3-(3-(p-Tolyl)ureido) benzoic acid]

Summary for 5I6D

• Entry DOI: 10.2210/pdb5i6d/pdb
• Related: 3DKI 3FGP
• Descriptor: O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 3-{[(4-methylphenyl)carbamoyl]amino}benzoic acid, ... (5 entities in total)
• Functional Keywords: cysteine synthase, mycobacterium tuberculosis, inhibitor, transferase, lyase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 141150.36

Authors

Schnell, R.,Maric, S.,Schneider, G. (deposition date: 2016-02-16, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Brunner, K.,Maric, S.,Reshma, R.S.,Almqvist, H.,Seashore-Ludlow, B.,Gustavsson, A.L.,Poyraz, O.,Yogeeswari, P.,Lundback, T.,Vallin, M.,Sriram, D.,Schnell, R.,Schneider, G.; Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.; J.Med.Chem., 59:6848-6859, 2016; PubMed: 27379713; DOI: 10.1021/acs.jmedchem.6b00674

Experimental method

X-RAY DIFFRACTION (1.64 Å)