5I6D
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 5 [3-(3-(p-Tolyl)ureido) benzoic acid]
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | O-phosphoserine sulfhydrylase | polymer | 326 | 34724.1 | 4 | UniProt (P9WP53) Pfam (PF00291) | Mycobacterium tuberculosis | OPS sulfhydrylase,CysO-thiocarboxylate-dependent cysteine synthase,Cysteine synthase B,CSase B,O-phosphoserine-specific cysteine synthase,[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase |
| 2 | E, H, K, M (A, B, C, D) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 4 | Chemie (PLP) | |||
| 3 | F, I, L, N (A, B, C, D) | 3-{[(4-methylphenyl)carbamoyl]amino}benzoic acid | non-polymer | 270.3 | 4 | Chemie (AU6) | |||
| 4 | G, J (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 892 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 323 (UniProt: P9WP53)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 2 | Thr 2 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138896.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2253.9 | |
| All* | Total formula weight | 141150.4 |
