1S3R | | CRYSTAL STRUCTURE OF THE HUMAN-SPECIFIC TOXIN INTERMEDILYSIN | | Descriptor: | intermedilysin, SULFATE ION | | Authors: | Polekhina, G., Giddings, K.S., Tweten, R.K., Parker, M.W. | | Deposit date: | 2004-01-14 | | Release date: | 2005-01-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1TUI | | INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP | | Descriptor: | ELONGATION FACTOR TU, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Polekhina, G., Thirup, S., Kjeldgaard, M., Nissen, P., Lippmann, C., Nyborg, J. | | Deposit date: | 1996-05-23 | | Release date: | 1997-06-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Helix unwinding in the effector region of elongation factor EF-Tu-GDP.
Structure, 4, 1996
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1Z0M | | THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE BETA1 SUBUNIT | | Descriptor: | 5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN | | Authors: | Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W. | | Deposit date: | 2005-03-02 | | Release date: | 2005-10-25 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005
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1Z0N | | THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE | | Descriptor: | 5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN | | Authors: | Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W. | | Deposit date: | 2005-03-02 | | Release date: | 2005-10-25 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005
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1FW1 | | GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE | | Descriptor: | GLUTATHIONE TRANSFERASE ZETA, SULFATE ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | | Authors: | Polekhina, G., Board, P.G., Blackburn, A.C., Parker, M.W. | | Deposit date: | 2000-09-20 | | Release date: | 2001-09-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.
Biochemistry, 40, 2001
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1K2F | | SIAH, SEVEN IN ABSENTIA HOMOLOG | | Descriptor: | siah-1A protein, ZINC ION, BETA-MERCAPTOETHANOL | | Authors: | Polekhina, G., House, C.M., Traficante, N., Mackay, J.P., Relaix, F., Sassoon, D.A., Parker, M.W., Bowtell, D.D.L. | | Deposit date: | 2001-09-26 | | Release date: | 2001-12-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Nat.Struct.Biol., 9, 2002
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2HGS | | HUMAN GLUTATHIONE SYNTHETASE | | Descriptor: | PROTEIN (GLUTATHIONE SYNTHETASE), MAGNESIUM ION, SULFATE ION, ... | | Authors: | Polekhina, G., Board, P., Rossjohn, J., Parker, M.W. | | Deposit date: | 1999-01-04 | | Release date: | 1999-06-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.
EMBO J., 18, 1999
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4GEI | | N-TERMINAL DOMAIN OF VDUP-1 | | Descriptor: | Thioredoxin-interacting protein | | Authors: | Polekhina, G., Kok, S.F., Ascher, D.B., Waltham, M. | | Deposit date: | 2012-08-02 | | Release date: | 2013-02-27 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the N-terminal domain of human thioredoxin-interacting protein.
Acta Crystallogr.,Sect.D, 69, 2013
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4GEJ | | N-TERMINAL DOMAIN OF VDUP-1 | | Descriptor: | Thioredoxin-interacting protein, CALCIUM ION | | Authors: | Polekhina, G., Kok, S.F., Ascher, D.B., Waltham, M. | | Deposit date: | 2012-08-02 | | Release date: | 2013-02-27 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of the N-terminal domain of human thioredoxin-interacting protein.
Acta Crystallogr.,Sect.D, 69, 2013
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1TTT | | PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX | | Descriptor: | TRANSFER RIBONUCLEIC ACID (YEAST, PHE), OF ELONGATION FACTOR TU (EF-TU), ... | | Authors: | Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L., Clark, B.F.C., Nyborg, J. | | Deposit date: | 1995-11-16 | | Release date: | 1996-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science, 270, 1995
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1LBK | | CRYSTAL STRUCTURE OF A RECOMBINANT GLUTATHIONE TRANSFERASE, CREATED BY REPLACING THE LAST SEVEN RESIDUES OF EACH SUBUNIT OF THE HUMAN CLASS PI ISOENZYME WITH THE ADDITIONAL C-TERMINAL HELIX OF HUMAN CLASS ALPHA ISOENZYME | | Descriptor: | Glutathione S-transferase class pi chimaera (CODA), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ... | | Authors: | Kong, G.K.W., Micaloni, C., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M. | | Deposit date: | 2002-04-04 | | Release date: | 2002-04-17 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.
J.Mol.Biol., 325, 2003
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1MD3 | | A FOLDING MUTANT OF HUMAN CLASS PI GLUTATHIONE TRANSFERASE, CREATED BY MUTATING GLYCINE 146 OF THE WILD-TYPE PROTEIN TO ALANINE | | Descriptor: | pi glutathione transferase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE | | Authors: | Kong, G.K.-W., Dragani, B., Aceto, A., Cocco, R., Mannervik, B., Stenberg, G., McKinstry, W.J., Polekhina, G., Parker, M.W. | | Deposit date: | 2002-08-06 | | Release date: | 2002-08-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1
J.Biol.Chem., 278, 2003
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1MD4 | | A FOLDING MUTANT OF HUMAN CLASS PI GLUTATHIONE TRANSFERASE, CREATED BY MUTATING GLYCINE 146 OF THE WILD-TYPE PROTEIN TO VALINE | | Descriptor: | pi glutathione transferase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE | | Authors: | Kong, G.K.-W., Dragani, B., Aceto, A., Cocco, R., Mannervik, B., Stenberg, G., McKinstry, W.J., Polekhina, G., Parker, M.W. | | Deposit date: | 2002-08-06 | | Release date: | 2002-08-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1
J.Biol.Chem., 278, 2003
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1PX6 | | A FOLDING MUTANT OF HUMAN CLASS PI GLUTATHIONE TRANSFERASE, CREATED BY MUTATING ASPARTATE 153 OF THE WILD-TYPE PROTEIN TO ASPARAGINE | | Descriptor: | Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE | | Authors: | Kong, G.K.-W., Polekhina, G., McKinstry, W.J., Parker, M.W., Dragani, B., Aceto, A., Paludi, D., Principe, D.R., Mannervik, B., Stenberg, G. | | Deposit date: | 2003-07-02 | | Release date: | 2003-07-22 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1
To be Published
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1PX7 | | A FOLDING MUTANT OF HUMAN CLASS PI GLUTATHIONE TRANSFERASE, CREATED BY MUTATING ASPARTATE 153 OF THE WILD-TYPE PROTEIN TO GLUTAMATE | | Descriptor: | Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ... | | Authors: | Kong, G.K.-W., Polekhina, G., McKinstry, W.J., Parker, M.W., Dragani, B., Aceto, A., Paludi, D., Principe, D.R., Mannervik, B., Stenberg, G. | | Deposit date: | 2003-07-02 | | Release date: | 2003-07-22 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1
To be Published
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1M3I | | PERFRINGOLYSIN O, NEW CRYSTAL FORM | | Descriptor: | perfringolysin O | | Authors: | Rossjohn, J., Parker, M., Polekhina, G., Feil, S., Tweten, R. | | Deposit date: | 2002-06-28 | | Release date: | 2004-02-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Snapshots in the Molecular Mechanism of PFO Revealed
To be Published
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1M3J | |
1PMT | | GLUTATHIONE TRANSFERASE FROM PROTEUS MIRABILIS | | Descriptor: | GLUTATHIONE TRANSFERASE, GLUTATHIONE | | Authors: | Rossjohn, J., Polekhina, G., Feil, S.C., Allocati, N., Masulli, M., Diilio, C., Parker, M.W. | | Deposit date: | 1998-03-23 | | Release date: | 1999-04-20 | | Last modified: | 2011-12-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Structure, 6, 1998
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2AN6 | | PROTEIN-PEPTIDE COMPLEX | | Descriptor: | Ubiquitin ligase SIAH1A, peptide from Phyllopod, ZINC ION | | Authors: | House, C.M., Hancock, N.C., Moller, A., Cromer, B.A., Fedorov, V., Bowtell, D.D.L., Parker, M.W., Polekhina, G. | | Deposit date: | 2005-08-11 | | Release date: | 2006-05-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Elucidation of the substrate binding site of Siah ubiquitin ligase
Structure, 14, 2006
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2PMT | | GLUTATHIONE TRANSFERASE FROM PROTEUS MIRABILIS | | Descriptor: | GLUTATHIONE TRANSFERASE, GLUTATHIONE | | Authors: | Rossjohn, J., Polekhina, G., Feil, S.C., Allocati, N., Masulli, M., Diilio, C., Parker, M.W. | | Deposit date: | 1998-04-28 | | Release date: | 1999-04-27 | | Last modified: | 2012-01-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Structure, 6, 1998
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3FFD | | STRUCTURE OF PARATHYROID HORMONE-RELATED PROTEIN COMPLEXED TO A NEUTRALIZING MONOCLONAL ANTIBODY | | Descriptor: | Monoclonal antibody, heavy chain, Fab fragment, ... | | Authors: | Mckinstry, W.J., Polekhina, G., Diefenbach-Jagger, H., Ho, P.W.M., Sato, K., Onuma, E., Gillespie, M.T., Martin, T.J., Parker, M.W. | | Deposit date: | 2008-12-03 | | Release date: | 2009-04-28 | | Last modified: | 2014-02-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor
J.Biol.Chem., 284, 2009
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2FHE | | FASCIOLA HEPATICA GLUTATHIONE S-TRANSFERASE ISOFORM 1 IN COMPLEX WITH GLUTATHIONE | | Descriptor: | GLUTATHIONE S-TRANSFERASE, GLUTATHIONE | | Authors: | Polekhina, G., Rossjohn, J., Feil, S.C., Parker, M.W. | | Deposit date: | 1998-10-21 | | Release date: | 1998-10-28 | | Last modified: | 2011-12-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase.
J.Mol.Biol., 273, 1997
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1EFC | | INTACT ELONGATION FACTOR FROM E.COLI | | Descriptor: | PROTEIN (ELONGATION FACTOR), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Song, H., Parsons, M.R., Rowsell, S., Leonard, G., Phillips, S.E.V. | | Deposit date: | 1998-11-24 | | Release date: | 1999-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of intact elongation factor EF-Tu from Escherichia coli in GDP conformation at 2.05 A resolution.
J.Mol.Biol., 285, 1999
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1LS2 | | FITTING OF EF-TU AND TRNA IN THE LOW RESOLUTION CRYO-EM MAP OF AN EF-TU TERNARY COMPLEX (GDP AND KIRROMYCIN) BOUND TO E. COLI 70S RIBOSOME | | Descriptor: | Phenylalanine transfer RNA, Elongation Factor Tu | | Authors: | Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., Frank, J. | | Deposit date: | 2002-05-16 | | Release date: | 2002-06-26 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (16.799999 Å) | | Cite: | Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
EMBO J., 21, 2002
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1LU3 | | SEPARATE FITTING OF THE ANTICODON LOOP REGION OF TRNA (NUCLEOTIDE 26-42) IN THE LOW RESOLUTION CRYO-EM MAP OF AN EF-TU TERNARY COMPLEX (GDP AND KIRROMYCIN) BOUND TO E. COLI 70S RIBOSOME | | Descriptor: | PHENYLALANINE TRANSFER RNA | | Authors: | Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., Frank, J. | | Deposit date: | 2002-05-21 | | Release date: | 2002-06-26 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (16.799999 Å) | | Cite: | Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
EMBO J., 21, 2002
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