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1I73
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COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:NEUTROPHIL COLLAGENASE, THREE RESIDUE PEPTIDE INHIBITOR, CALCIUM ION, ...
Authors:Gavuzzo, E., Pochetti, G., Mazza, F., Gallina, C., Gorini, B., D'Alessio, S., Pieper, M., Tschesche, H., Tucker, P.A.
Deposit date:2001-03-07
Release date:2001-03-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
J.Med.Chem., 43, 2000
1I76
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COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ...
Authors:Gavuzzo, E., Pochetti, G., Mazza, F., Gallina, C., Gorini, B., D'Alessio, S., Pieper, M., Tschesche, H., Tucker, P.A.
Deposit date:2001-03-08
Release date:2001-03-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
J.Med.Chem., 43, 2000
1JAN
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COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (PHE79 FORM), PRO-LEU-GLY-HYDROXYLAMINE INHIBITOR, CALCIUM ION, ...
Authors:Reinemer, P., Grams, F., Huber, R., Kleine, T., Schnierer, S., Pieper, M., Tschesche, H., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS Lett., 338, 1994
1MMB
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COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8
Descriptor:MATRIX METALLOPROTEINASE-8, CALCIUM ION, ZINC ION, ...
Authors:Bode, W., Grams, F.
Deposit date:1995-08-23
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Biochemistry, 34, 1995
1JAO
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COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), N-[(2S)-2-benzyl-3-sulfanylpropanoyl]-L-alanylglycinamide, CALCIUM ION, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1JAQ
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COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), CALCIUM ION, N-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1KBC
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PROCARBOXYPEPTIDASE TERNARY COMPLEX
Descriptor:NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ...
Authors:Betz, M., Gomis-Rueth, F.X., Bode, W.
Deposit date:1997-04-29
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
Eur.J.Biochem., 247, 1997
1ZS0
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (S-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-05-23
Release date:2006-05-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
1ZVX
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (R-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-06-03
Release date:2006-05-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
1ZP5
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A N-HYDROXYUREA INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Campestre, C., Agamennone, M., Tortorella, P., Preziuso, S., Biasone, A., Gavuzzo, E., Pochetti, G., Mazza, F., Tschesche, H., Gallina, C.
Deposit date:2005-05-16
Release date:2005-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8.
Bioorg.Med.Chem.Lett., 16, 2006
1JAP
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COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), PRO-LEU-GLY-HYDROXYLAMINE, CALCIUM ION, ...
Authors:Bode, W., Reinemer, P., Huber, R., Kleine, T., Schnierer, S., Tschesche, H.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
EMBO J., 13, 1994