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1CTN
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CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION
Descriptor:CHITINASE A
Authors:Perrakis, A., Tews, I., Dauter, Z., Wilson, K.S., Vorgias, C.E.
Deposit date:1994-10-10
Release date:1995-02-07
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a bacterial chitinase at 2.3 A resolution.
Structure, 2, 1994
6QCG
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PCNA COMPLEX WITH CDT1 N-TERMINAL PIP-BOX PEPTIDE
Descriptor:Proliferating cell nuclear antigen, DNA replication factor Cdt1
Authors:Perrakis, A., von Castelmur, E.
Deposit date:2018-12-28
Release date:2019-01-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1.
Life Sci Alliance, 1, 2018
1OH5
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH
Descriptor:DNA MISMATCH REPAIR PROTEIN MUTS, 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*CP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP *CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*AP*TP*GP*GP *CP*AP*GP*CP*T)-3', ...
Authors:Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1OH6
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH
Descriptor:DNA MISMATCH REPAIR PROTEIN MUTS, 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*AP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP* CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*AP*TP*GP*GP* CP*AP*GP*CP*T)-3', ...
Authors:Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1OH7
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH
Descriptor:DNA MISMATCH REPAIR PROTEIN MUTS, 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP *CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*GP*TP*GP*GP *CP*AP*GP*CP*T)-3', ...
Authors:Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1OH8
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE
Descriptor:DNA MISMATCH REPAIR PROTEIN MUTS, 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP* TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*CP*TP*TP*GP*GP*CP* AP*GP*CP*T)-3', ...
Authors:Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
2X4P
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CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2.1, BETA-2-MICROGLOBULIN, ...
Authors:Celie, P.H.N., Toebes, M., Rodenko, B., Ovaa, H., Perrakis, A., Schumacher, T.N.M.
Deposit date:2010-02-02
Release date:2010-03-02
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
2X4Q
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CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2.1, BETA-2-MICROGLOBULIN, ...
Authors:Celie, P.H.N., Toebes, M., Rodenko, B., Ovaa, H., Perrakis, A., Schumacher, T.N.M.
Deposit date:2010-02-02
Release date:2010-03-02
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
2X4T
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CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PEIODATE- CLEAVABLE PEPTIDE
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2.1, BETA-2-MICROGLOBULIN, ...
Authors:Rodenko, B., Toebes, M., Celie, P.H.N., Perrakis, A., Schumacher, T.N.M., Ovaa, H.
Deposit date:2010-02-02
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
2XR9
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kamtekar, S., Hausmann, J., Day, J.E., Christodoulou, E., Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
2W8F
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APLYSIA CALIFORNICA ACHBP BOUND TO IN SILICO COMPOUND 31
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Edink, E., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., de Esch, I.J.
Deposit date:2009-01-16
Release date:2009-04-14
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis.
J.Med.Chem., 52, 2009
2W8G
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APLYSIA CALIFORNICA ACHBP BOUND TO IN SILICO COMPOUND 35
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, (3-ENDO,8-ANTI)-8-BENZYL-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8-AZONIABICYCLO[3.2.1]OCTANE
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Edink, E., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., de Esch, I.J.
Deposit date:2009-01-16
Release date:2009-04-14
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis.
J.Med.Chem., 52, 2009
2Y7Y
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APLYSIA CALIFORNICA ACHBP IN APO STATE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., De Esch, I.J.
Deposit date:2011-02-02
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-Ray Analysis.
J.Med.Chem., 52, 2009
1DCS
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DEACETOXYCEPHALOSPORIN C SYNTHASE FROM S. CLAVULIGERUS
Descriptor:DEACETOXYCEPHALOSPORIN C SYNTHASE, SULFATE ION
Authors:Valegard, K., Terwisscha Van Scheltinga, A.C., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.J., Baldwin, J.E., Schofield, C.J., Hajdu, J., Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
1DW9
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STRUCTURE OF CYANASE REVEALS THAT A NOVEL DIMERIC AND DECAMERIC ARRANGEMENT OF SUBUNITS IS REQUIRED FOR FORMATION OF THE ENZYME ACTIVE SITE
Descriptor:CYANATE LYASE, CHLORIDE ION, SULFATE ION
Authors:Walsh, M.A., Otwinowski, Z., Perrakis, A., Anderson, P.M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:1999-12-03
Release date:2000-05-16
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site
Structure, 8, 2000
1DWK
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STRUCTURE OF CYANASE WITH THE DI-ANION OXALATE BOUND AT THE ENZYME ACTIVE SITE
Descriptor:CYANATE HYDRATASE, SULFATE ION, OXALATE ION
Authors:Walsh, M.A., Otwinowski, Z., Perrakis, A., Anderson, P.M., Joachimiak, A.
Deposit date:1999-12-07
Release date:2000-05-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site.
Structure, 8, 2000
1EPU
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X-RAY CRYSTAL STRUCTURE OF NEURONAL SEC1 FROM SQUID
Descriptor:S-SEC1
Authors:Bracher, A., Perrakis, A., Dresbach, T., Betz, H., Weissenhorn, W.
Deposit date:2000-03-29
Release date:2000-08-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis.
Structure Fold.Des., 8, 2000
1O9K
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CRYSTAL STRUCTURE OF THE RETINOBLASTOMA TUMOUR SUPPRESSOR PROTEIN BOUND TO E2F PEPTIDE
Descriptor:RETINOBLASTOMA-ASSOCIATED PROTEIN, TRANSCRIPTION FACTOR E2F1
Authors:Xiao, B., Spencer, J., Clements, A., Ali-Khan, N., Mittnacht, S., Broceno, C., Burghammer, M., Perrakis, A., Marmorstein, R., Gamblin, S.J.
Deposit date:2002-12-16
Release date:2003-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Retinoblastoma Tumor Suppressor Protein Bound to E2F and the Molecular Basis of its Regulation
Proc.Natl.Acad.Sci.USA, 100, 2003
1QBA
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BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20
Descriptor:CHITOBIASE, SULFATE ION
Authors:Tews, I., Perrakis, A., Oppenheim, A., Dauter, Z., Wilson, K.S., Vorgias, C.E.
Deposit date:1996-06-06
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.
Nat.Struct.Biol., 3, 1996
1QBB
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BACTERIAL CHITOBIASE COMPLEXED WITH CHITOBIOSE (DINAG)
Descriptor:CHITOBIASE, DI(N-ACETYL-D-GLUCOSAMINE), SULFATE ION
Authors:Tews, I., Perrakis, A., Oppenheim, A., Dauter, Z., Wilson, K.S., Vorgias, C.E.
Deposit date:1996-06-07
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.
Nat.Struct.Biol., 3, 1996
1RXF
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DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH FE(II)
Descriptor:DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (III) ION
Authors:Valegard, K., Terwisscha Van Scheltinga, A.C., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.J., Baldwin, J.E., Schofield, C.J., Hajdu, J., Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
1RXG
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DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH FE(II) AND 2-OXOGLUTARATE
Descriptor:DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (III) ION, SULFATE ION, ...
Authors:Valegard, K., Terwisscha Van Scheltinga, A.C., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.J., Baldwin, J.E., Shofield, C.J., Hajdu, J., Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
2KLS
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APO-FORM OF THE SECOND CA2+ BINDING DOMAIN OF NCX1.4
Descriptor:Sodium/calcium exchanger 1
Authors:Hilge, M., Aelen, J., Foarce, A., Perrakis, A., Vuister, G.W.
Deposit date:2009-07-08
Release date:2009-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
2KLT
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SECOND CA2+ BINDING DOMAIN OF NCX1.3
Descriptor:Sodium/calcium exchanger 1
Authors:Hilge, M., Aelen, J., Foarce, A., Perrakis, A., Vuister, G.W.
Deposit date:2009-07-08
Release date:2009-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
2WVR
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HUMAN CDT1:GEMININ COMPLEX
Descriptor:GEMININ, DNA REPLICATION FACTOR CDT1
Authors:De Marco, V., Perrakis, A.
Deposit date:2009-10-19
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Quaternary Structure of the Human Cdt1-Geminin Complex Regulates DNA Replication Licensing.
Proc.Natl.Acad.Sci.USA, 106, 2009