2XRG

Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor

Summary for 2XRG

• Entry DOI: 10.2210/pdb2xrg/pdb
• Related: 2XR9
• Descriptor: ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {4-[(4-{(Z)-[3-(4-FLUOROBENZYL)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE]METHYL}PHENOXY)METHYL]PHENYL}(TRIHYDROXY)BORATE(1-), ... (7 entities in total)
• Functional Keywords: hydrolase, lysophosphatidic acid, lpa, lysophosphatidylcholine, lpc, somatomedin, metastasis, neuropathic pain, vascular development, neural development
• Biological source: RATTUS NORVEGICUS (NORWAY RAT)
• Total number of polymer chains: 1
• Total formula weight: 100741.46

Authors

Hausmann, J.,Albers, H.M.H.G.,Perrakis, A. (deposition date: 2010-09-14, release date: 2011-01-19, Last modification date: 2023-12-20)

• Primary citation: Hausmann, J.,Kamtekar, S.,Christodoulou, E.,Day, J.E.,Wu, T.,Fulkerson, Z.,Albers, H.M.H.G.,Van Meeteren, L.A.,Houben, A.J.,Van Zeijl, L.,Jansen, S.,Andries, M.,Hall, T.,Pegg, L.E.,Benson, T.E.,Kasiem, M.,Harlos, K.,Kooi, C.W.,Smyth, S.S.,Ovaa, H.,Bollen, M.,Morris, A.J.,Moolenaar, W.H.,Perrakis, A.; Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.; Nat.Struct.Mol.Biol., 18:198-, 2011; PubMed: 21240271; DOI: 10.1038/NSMB.1980

Experimental method

X-RAY DIFFRACTION (3.2 Å)