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1CTN
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BU of 1ctn by Molmil
CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION
Descriptor: CHITINASE A
Authors:Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E.
Deposit date:1994-10-10
Release date:1995-02-07
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a bacterial chitinase at 2.3 A resolution.
Structure, 2, 1994
6QCG
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BU of 6qcg by Molmil
PCNA complex with Cdt1 N-terminal PIP-box peptide
Descriptor: DNA replication factor Cdt1, Proliferating cell nuclear antigen
Authors:Perrakis, A, von Castelmur, E.
Deposit date:2018-12-28
Release date:2019-01-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1.
Life Sci Alliance, 1, 2018
8ARF
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BU of 8arf by Molmil
Crystal structure of the N-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein Spindly
Descriptor: Protein Spindly
Authors:Perrakis, A, Ahmad, M.U.
Deposit date:2022-08-16
Release date:2022-09-07
Last modified:2022-09-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.
J.Cell Biol., 221, 2022
7P0K
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BU of 7p0k by Molmil
Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand
Descriptor: 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands
J Med Chem, 64, 2021
5C9N
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BU of 5c9n by Molmil
Crystal structure of GEMC1 coiled-coil domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Geminin coiled-coil domain-containing protein 1
Authors:Caillat, C, Perrakis, A.
Deposit date:2015-06-28
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.
Acta Crystallogr.,Sect.D, 71, 2015
6NVQ
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BU of 6nvq by Molmil
Crystal structure of the VASH1-SVBP complex
Descriptor: GLYCEROL, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Adamopoulos, A, Perrakis, A, Heidebrecht, T.
Deposit date:2019-02-05
Release date:2019-05-22
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Nat.Struct.Mol.Biol., 26, 2019
6FPV
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BU of 6fpv by Molmil
A llama-derived JBP1-targeting nanobody
Descriptor: GLYCEROL, Nanobody
Authors:van Beusekom, B, Adamopoulos, A, Heidebrecht, T, Joosten, R.P, Perrakis, A.
Deposit date:2018-02-12
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.
Acta Crystallogr F Struct Biol Commun, 74, 2018
3KJY
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BU of 3kjy by Molmil
Crystal structure of reduced HOMO SAPIENS CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-11-04
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
5DLV
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BU of 5dlv by Molmil
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA)
Descriptor: 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Keune, W.J, Heidebrecht, T, von Castelmur, E, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5DLT
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BU of 5dlt by Molmil
Crystal structure of Autotaxin (ENPP2) with 7-alpha-hydroxycholesterol
Descriptor: 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5DLW
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BU of 5dlw by Molmil
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, ...
Authors:Keune, W.J, Heidebrecht, T, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5IJQ
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BU of 5ijq by Molmil
Crystal structure of autotaxin (ENPP2) re-refined
Descriptor: 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2016-03-02
Release date:2016-06-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
5IJS
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BU of 5ijs by Molmil
Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2016-03-02
Release date:2016-06-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
3G73
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BU of 3g73 by Molmil
Structure of the FOXM1 DNA binding
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ...
Authors:Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
6GVJ
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BU of 6gvj by Molmil
Human Mps1 kinase domain with ordered activation loop
Descriptor: CHLORIDE ION, Dual specificity protein kinase TTK, GLYCEROL
Authors:Roorda, J.C, Hiruma, Y, Joosten, R.P, Perrakis, A.
Deposit date:2018-06-21
Release date:2019-01-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.
Proteins, 87, 2019
1VYB
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BU of 1vyb by Molmil
Endonuclease domain of human LINE1 ORF2p
Descriptor: GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ...
Authors:Weichenrieder, O, Repanas, K, Perrakis, A.
Deposit date:2004-04-25
Release date:2004-06-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.
Structure, 12, 2004
3FY7
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BU of 3fy7 by Molmil
Crystal structure of homo sapiens CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-01-22
Release date:2009-02-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
2CKL
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BU of 2ckl by Molmil
Ring1b-Bmi1 E3 catalytic domain structure
Descriptor: IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ...
Authors:Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K.
Deposit date:2006-04-20
Release date:2006-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
1DCS
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BU of 1dcs by Molmil
DEACETOXYCEPHALOSPORIN C SYNTHASE FROM S. CLAVULIGERUS
Descriptor: DEACETOXYCEPHALOSPORIN C SYNTHASE, SULFATE ION
Authors:Valegard, K, Terwisscha Van Scheltinga, A.C, Lloyd, M.D, Hara, T, Ramaswamy, S, Perrakis, A, Thompson, A, Lee, H.J, Baldwin, J.E, Schofield, C.J, Hajdu, J, Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
4B94
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BU of 4b94 by Molmil
Crystal structure of human Mps1 TPR domain
Descriptor: DI(HYDROXYETHYL)ETHER, DUAL SPECIFICITY PROTEIN KINASE TTK, GLYCEROL, ...
Authors:Littler, D, von Castelmur, E, De Marco, V, Perrakis, A.
Deposit date:2012-08-31
Release date:2013-04-24
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Tpr Domain-Containing N-Terminal Module of Mps1 is Required for its Kinetochore Localization by Aurora B.
J.Cell Biol., 201, 2013
4B56
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BU of 4b56 by Molmil
Structure of ectonucleotide pyrophosphatase-phosphodiesterase-1 (NPP1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Jansen, S, Perrakis, A, Ulens, C, Winkler, C, Andries, M, Joosten, R.P, Van Acker, M, Luyten, F.P, Moolenaar, W.H, Bollen, M.
Deposit date:2012-08-02
Release date:2012-09-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Npp1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification.
Structure, 20, 2012
4BRY
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BU of 4bry by Molmil
The Idas:Geminin heterodimeric parallel coiled-coil
Descriptor: GEMININ, MULTICILIN, PHOSPHATE ION, ...
Authors:Caillat, C, Perrakis, A.
Deposit date:2013-06-06
Release date:2013-10-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer that Inhibits Geminin Function in DNA Replication Licensing
J.Biol.Chem., 288, 2013
7A5U
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BU of 7a5u by Molmil
Structure of E37A BlaC from Mycobacterium tuberculosis
Descriptor: Beta-lactamase
Authors:Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M.
Deposit date:2020-08-21
Release date:2021-04-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conserved residues Glu37 and Trp229 play an essential role in protein folding of beta-lactamase.
Febs J., 288, 2021
7A74
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Structure of G132N BlaC from Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ...
Authors:Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M.
Deposit date:2020-08-27
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics.
Antimicrob.Agents Chemother., 65, 2021
7A5W
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BU of 7a5w by Molmil
Structure of D172N BlaC from Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase
Authors:Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M.
Deposit date:2020-08-24
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
Biochemistry, 60, 2021

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