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1COL
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BU of 1col by Molmil
REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION
Descriptor: COLICIN A
Authors:Parker, M.W, Postma, J.P.M, Pattus, F, Tucker, A.D, Tsernoglou, D.
Deposit date:1991-07-06
Release date:1992-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Refined structure of the pore-forming domain of colicin A at 2.4 A resolution.
J.Mol.Biol., 224, 1992
1PRE
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BU of 1pre by Molmil
PROAEROLYSIN
Descriptor: PROAEROLYSIN
Authors:Parker, M.W, Buckley, J.T, Postma, J.P.M, Tucker, A.D, Tsernoglou, D.
Deposit date:1995-09-15
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature, 367, 1994
4QDQ
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BU of 4qdq by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: GLYCEROL, Neuropilin-2, SULFATE ION
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDR
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BU of 4qdr by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: Neuropilin-2
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDS
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BU of 4qds by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: ACETATE ION, GLYCEROL, Neuropilin-2
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
1Z52
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BU of 1z52 by Molmil
Proaerolysin Mutant W373L
Descriptor: Aerolysin
Authors:Parker, M.W, Feil, S.C, Tang, J.W.
Deposit date:2005-03-16
Release date:2006-03-07
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin
To be Published
5DHL
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BU of 5dhl by Molmil
Crystal structure of Toxin, mutant N197W
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Perfringolysin O
Authors:Parker, M.W, Gorman, M.A, Lawrence, S.L.
Deposit date:2015-08-31
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structure of mutant toxin
To Be Published
5DIM
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BU of 5dim by Molmil
Mutant toxin in 'native' space group
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Perfringolysin O
Authors:Parker, M.W, Gorman, M.A, Lawrence, S.L.
Deposit date:2015-09-01
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure of mutant toxin at 3.32 Angstrom resolution
To Be Published
4ZGH
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BU of 4zgh by Molmil
Structure of Sugar Binding Protein Pneumolysin
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GOLD (I) CYANIDE ION, ...
Authors:Parker, M.W, Feil, S.C, Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
4NKQ
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BU of 4nkq by Molmil
Structure of a Cytokine Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Parker, M.W, Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
1GSS
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BU of 1gss by Molmil
THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
Descriptor: GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-hexyl-L-cysteinylglycine
Authors:Reinemer, P, Dirr, H.W, Ladenstein, R, Lobello, M, Federici, G, Huber, R, Parker, M.W.
Deposit date:1992-05-28
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
J.Mol.Biol., 227, 1992
6PRO
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BU of 6pro by Molmil
MnSOD from Geobacillus stearothermophilus
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Adams, J.J, Morton, C.J, Parker, M.W.
Deposit date:2019-07-10
Release date:2020-05-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.263 Å)
Cite:The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited
Aust.J.Chem., 73, 2020
2LJR
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BU of 2ljr by Molmil
GLUTATHIONE TRANSFERASE APO-FORM FROM HUMAN
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Rossjohn, J, Mckinstry, W.J, Oakley, A.J, Verger, D, Flanagan, J, Chelvanayagam, G, Tan, K.L, Board, P.G, Parker, M.W.
Deposit date:1998-03-08
Release date:1999-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site.
Structure, 6, 1998
2A2R
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BU of 2a2r by Molmil
Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ...
Authors:Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2A2S
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BU of 2a2s by Molmil
Crystal Structure of Human Glutathione Transferase in complex with S-nitrosoglutathione in the absence of reducing agent
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ...
Authors:Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2AEW
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BU of 2aew by Molmil
A model for growth hormone receptor activation based on subunit rotation within a receptor dimer
Descriptor: Growth hormone receptor
Authors:Adams, J.J, McKinstry, W.J, Parker, M.W, Waters, M.J.
Deposit date:2005-07-24
Release date:2005-11-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Nat.Struct.Mol.Biol., 12, 2005
6PDG
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BU of 6pdg by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83
Descriptor: 5-ethoxy-2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
6PDA
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BU of 6pda by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74
Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyridin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.448 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
6PDE
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BU of 6pde by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40
Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-propoxybenzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
8G32
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BU of 8g32 by Molmil
Pro-form of a CDCL short from E. anophelis
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Nat Commun, 15, 2024
8G33
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BU of 8g33 by Molmil
Activated form of a CDCL long protein
Descriptor: Hemolysin
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Activated form of a CDCL long protein
To Be Published
4Y0G
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BU of 4y0g by Molmil
beta2 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK)
Descriptor: 5'-AMP-activated protein kinase subunit beta-2, GLYCEROL
Authors:Mobbs, J, Gorman, M.A, Parker, M.W, Gooley, P.R, Griffin, M.
Deposit date:2015-02-06
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.
Biochem.J., 468, 2015
4XXD
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BU of 4xxd by Molmil
Crystal Structure of mid-region amyloid beta capture by solanezumab
Descriptor: Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain
Authors:Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A.
Deposit date:2015-01-30
Release date:2015-04-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies.
Sci Rep, 5, 2015
6BFQ
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BU of 6bfq by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Descriptor: Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
1S3R
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BU of 1s3r by Molmil
Crystal structure of the human-specific toxin intermedilysin
Descriptor: SULFATE ION, intermedilysin
Authors:Polekhina, G, Giddings, K.S, Tweten, R.K, Parker, M.W.
Deposit date:2004-01-14
Release date:2005-01-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
Proc.Natl.Acad.Sci.Usa, 102, 2005

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