Author results

1COL
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REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION
Descriptor:COLICIN A
Authors:Parker, M.W., Postma, J.P.M., Pattus, F., Tucker, A.D., Tsernoglou, D.
Deposit date:1991-07-06
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Refined structure of the pore-forming domain of colicin A at 2.4 A resolution.
J.Mol.Biol., 224, 1992
1PRE
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PROAEROLYSIN
Descriptor:PROAEROLYSIN
Authors:Parker, M.W., Buckley, J.T., Postma, J.P.M., Tucker, A.D., Tsernoglou, D.
Deposit date:1995-09-15
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature, 367, 1994
1Z52
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PROAEROLYSIN MUTANT W373L
Descriptor:Aerolysin
Authors:Parker, M.W., Feil, S.C., Tang, J.W.
Deposit date:2005-03-16
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin
To be Published
4QDQ
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PHYSICAL BASIS FOR NRP2 LIGAND BINDING
Descriptor:Neuropilin-2, GLYCEROL, SULFATE ION
Authors:Parker, M.W., Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDR
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PHYSICAL BASIS FOR NRP2 LIGAND BINDING
Descriptor:Neuropilin-2
Authors:Parker, M.W., Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDS
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PHYSICAL BASIS FOR NRP2 LIGAND BINDING
Descriptor:Neuropilin-2, GLYCEROL, ACETATE ION
Authors:Parker, M.W., Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
5DHL
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CRYSTAL STRUCTURE OF TOXIN, MUTANT N197W
Descriptor:Perfringolysin O, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Parker, M.W., Gorman, M.A., Lawrence, S.L.
Deposit date:2015-08-31
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structure of mutant toxin
To Be Published
5DIM
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MUTANT TOXIN IN 'NATIVE' SPACE GROUP
Descriptor:Perfringolysin O, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Parker, M.W., Gorman, M.A., Lawrence, S.L.
Deposit date:2015-09-01
Release date:2016-11-09
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure of mutant toxin at 3.32 Angstrom resolution
To Be Published
4NKQ
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STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4ZGH
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STRUCTURE OF SUGAR BINDING PROTEIN PNEUMOLYSIN
Descriptor:Pneumolysin, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Parker, M.W., Feil, S.C., Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
1ZGN
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CRYSTAL STRUCTURE OF THE GLUTATHIONE TRANSFERASE PI IN COMPLEX WITH DINITROSYL-DIGLUTATHIONYL IRON COMPLEX
Descriptor:Glutathione S-transferase P, FE (III) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Parker, L.J., Adams, J.J., Parker, M.W.
Deposit date:2005-04-21
Release date:2005-11-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
J.Biol.Chem., 280, 2005
2A2R
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE PI IN COMPLEX WITH S-NITROSOGLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2A2S
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE IN COMPLEX WITH S-NITROSOGLUTATHIONE IN THE ABSENCE OF REDUCING AGENT
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
3N9J
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STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI CLASS IN COMPLEX WITH ETHACRAPLATIN
Descriptor:Glutathione S-transferase P, PLATINUM (II) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Parker, L.J., Parker, M.W.
Deposit date:2010-05-30
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
To be Published
5DAK
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI COMPLEXED WITH A METALLOID IN THE ABSENCE OF GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARSENIC
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-20
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DAL
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI COMPLEXED WITH A METALLOID IN THE PRESENCE OF GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Di-glutathione-PhenylArsine, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-20
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DCG
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CRYSTAL STRUCTURE OF WT APO HUMAN GLUTATHIONE TRANSFERASE PI
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHATE ION, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-24
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DDL
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CRYSTAL STRUCTURE OF WT HUMAN GLUTATHIONE TRANSFERASE PI SOAKED WITH A METALLOID THEN BACK-SOAKED WITH GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Di-glutathione-PhenylArsine, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-25
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
19GS
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GLUTATHIONE S-TRANSFERASE P1-1
Descriptor:GLUTATHIONE S-TRANSFERASE, 3,3'-(4,5,6,7-TETRABROMO-3-OXO-1(3H)-ISOBENZOFURANYLIDENE)BIS [6-HYDROXYBENZENESULFONIC ACID]ANION, GLUTATHIONE, ...
Authors:Oakley, A.J., Lo Bello, M., Parker, M.W.
Deposit date:1997-12-14
Release date:1998-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
1A87
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COLICIN N
Descriptor:COLICIN N
Authors:Vetter, I.R., Parker, M.W., Tucker, A.D., Lakey, J.H., Pattus, F., Tsernoglou, D.
Deposit date:1998-04-03
Release date:1999-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of a colicin N fragment suggests a model for toxicity.
Structure, 6, 1998
1KOA
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TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
Descriptor:TWITCHIN
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1KOB
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TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN
Descriptor:TWITCHIN, VALINE
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1S3R
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CRYSTAL STRUCTURE OF THE HUMAN-SPECIFIC TOXIN INTERMEDILYSIN
Descriptor:intermedilysin, SULFATE ION
Authors:Polekhina, G., Giddings, K.S., Tweten, R.K., Parker, M.W.
Deposit date:2004-01-14
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Z0M
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THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE BETA1 SUBUNIT
Descriptor:5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN
Authors:Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W.
Deposit date:2005-03-02
Release date:2005-10-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005
1Z0N
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THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE
Descriptor:5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN
Authors:Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W.
Deposit date:2005-03-02
Release date:2005-10-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005