Author results

2OCS
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THE CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF HUMAN NHERF-2 (SLC9A3R2)
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF2, THIOCYANATE ION, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Phillips, C., Gileadi, C., Elkins, J., Salah, E., Berridge, G., Savitsky, P., Gorrec, F., Umeano, C., Ugochukwu, E., Gileadi, O., Burgess, N., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-12-21
Release date:2007-01-16
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)
To be Published
2QG1
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CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZ (MUPP1)
Descriptor:Multiple PDZ domain protein, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Salah, E., Phillips, C., Savitsky, P., Boisguerin, P., Oschkinat, H., Gileadi, C., Yang, X., Elkins, J.M., Ugochukwu, E., Bunkoczi, G., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the 11th PDZ domain of MPDZ (MUPP1).
To be Published
2ERX
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CRYSTAL STRUCTURE OF DIRAS2 IN COMPLEX WITH GDP AND INORGANIC PHOSPHATE
Descriptor:GTP-binding protein Di-Ras2, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Papagrigoriou, E., Yang, X., Elkins, J., Niesen, F.E., Burgess, N., Salah, E., Fedorov, O., Ball, L.J., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.
Deposit date:2005-10-25
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of DiRas2
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
Descriptor:Dual specificity protein kinase CLK3
Authors:Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-08
Release date:2005-11-15
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2GF2
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CRYSTAL STRUCTURE OF HUMAN HYDROXYISOBUTYRATE DEHYDROGENASE
Descriptor:3-hydroxyisobutyrate dehydrogenase
Authors:Papagrigoriou, E., Salah, E., Turnbull, A.P., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Gorrec, F., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-03-21
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of human hydroxyisobutyrate dehydrogenase
To be Published
2O2T
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THE CRYSTAL STRUCTURE OF THE 1ST PDZ DOMAIN OF MPDZ
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Gileadi, C., Phillips, C., Johansson, C., Salah, E., Savitsky, P., Gorrec, F., Umeano, C., Berridge, G., Pike, A.C.W., Elkins, J., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-11-30
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of the 1st PDZ domain of MPDZ
To be Published
2P02
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CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2
Descriptor:S-adenosylmethionine synthetase isoform type-2, CHLORIDE ION, S-ADENOSYLMETHIONINE
Authors:Papagrigoriou, E., Shafqat, N., Rojkova, A., Niessen, F.H., Kavanagh, K.L., von Delft, F., Gorrec, F., Ugochukwu, E., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-02-28
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
To be Published
2REY
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN DISHEVELLED 2 (HOMOLOGOUS TO DROSOPHILA DSH)
Descriptor:Segment polarity protein dishevelled homolog DVL-2
Authors:Papagrigoriou, E., Gileadi, C., Elkins, J., Cooper, C., Ugochukwu, E., Turnbull, A., Pike, A.C.W., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-10-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh).
To be Published
1SJ7
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CRYSTAL STRUCTURE OF TALIN ROD 482-655
Descriptor:Talin 1, PLATINUM (II) ION
Authors:Papagrigoriou, E., Gingras, A.R., Barsukov, I.L., Critchley, D.R., Emsley, J.
Deposit date:2004-03-03
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
1SJ8
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CRYSTAL STRUCTURE OF TALIN RESIDUES 482-789
Descriptor:Talin 1
Authors:Papagrigoriou, E., Gingras, A.R., Barsukov, I.L., Critchley, D.R., Emsley, J.
Deposit date:2004-03-03
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
1T01
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VINCULIN COMPLEXED WITH THE VBS1 HELIX FROM TALIN
Descriptor:unnamed protein product, Talin 1
Authors:Papagrigoriou, E., Gingras, A.R., Barsukov, I.L., Critchley, D.R., Emsley, J.
Deposit date:2004-04-07
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
Embo J., 23, 2004
2AW5
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CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYME
Descriptor:NADP-dependent malic enzyme
Authors:Papagrigoriou, E., Berridge, G., Smee, C., Bray, J., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Gileadi, O., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2005-08-31
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a human malic enzyme
To be published
2B05
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CRYSTAL STRUCTURE OF 14-3-3 GAMMA IN COMPLEX WITH A PHOSPHOSERINE PEPTIDE
Descriptor:14-3-3 protein gamma, peptide
Authors:Papagrigoriou, E., Elkins, J., Arrowsmith, C., Zhao, Y., Debreczeni, E.J., Edwards, A., Weigelt, J., Doyle, D., von Delft, F., Turnbull, A., Yang, X.
Deposit date:2005-09-13
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide
TO BE PUBLISHED
2F83
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CRYSTAL STRUCTURE AT 2.9 ANGSTROMS RESOLUTION OF HUMAN PLASMA COAGULATION FACTOR XI ZYMOGEN
Descriptor:Coagulation factor XI, N-ACETYL-D-GLUCOSAMINE, PLATINUM (II) ION
Authors:Papagrigoriou, E., McEwan, P.A., Walsh, P.N., Emsley, J.
Deposit date:2005-12-01
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Crystal structure of the factor XI zymogen reveals a pathway for transactivation.
Nat.Struct.Mol.Biol., 13, 2006
2H5G
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CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE SYNTHETASE
Descriptor:Delta 1-pyrroline-5-carboxylate synthetase, SULFATE ION
Authors:Papagrigoriou, E., Shafqat, N., Turnbull, A.P., Berridge, G., Hozjan, V., Kavanagh, K., Gileadi, O., Smee, C., Bray, J., Gorrec, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-05-26
Release date:2006-06-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human pyrroline-5-carboxylate synthetase
To be published
2IIK
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CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL ACETYL-COA ACYL TRANSFERASE 1 (ACAA1)
Descriptor:3-ketoacyl-CoA thiolase, peroxisomal
Authors:Papagrigoriou, E., Johansson, C., Smee, C., Kavanagh, K., Pike, A.C.W., Sundstrom, M., Weigelt, J., Edwards, A., Arrowsmith, C.H., Gileadi, O., Gorrec, F., Umeano, C., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-09-28
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1)
TO BE PUBLISHED
2EU9
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CRYSTAL STRUCTURE OF CLK3
Descriptor:Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Rellos, P., Das, S., Ugochukwu, E., Turnbull, A., von Delft, F., Bunkoczi, G., Sobott, F., Bullock, A., Fedorov, O., Gileadi, C., Savitsky, P., Edwards, A., Aerrowsmith, C., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2005-10-28
Release date:2005-11-08
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2FCF
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THE CRYSTAL STRUCTURE OF THE 7TH PDZ DOMAIN OF MPDZ (MUPP-1)
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Berridge, G., Johansson, C., Colebrook, S., Salah, E., Burgess, N., Smee, C., Savitsky, P., Bray, J., Schoch, G., Phillips, C., Gileadi, C., Soundarajan, M., Yang, X., Elkins, J.M., Gorrec, F., Turnbull, A., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-12-12
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2FNE
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THE CRYSTAL STRUCTURE OF THE 13TH PDZ DOMAIN OF MPDZ
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Berridge, G., Johansson, C., Colebrook, S., Salah, E., Burgess, N., Smee, C., Savitsky, P., Bray, J., Schoch, G., Phillips, C., Gileadi, C., Soundarajan, M., Yang, X., Elkins, J.M., Gorrec, F., Turnbull, A., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-01-11
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2HE4
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THE CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF HUMAN NHERF-2 (SLC9A3R2) INTERACTING WITH A MODE 1 PDZ BINDING MOTIF
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF2, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Elkins, J.M., Berridge, G., Gileady, O., Colebrook, S., Gileadi, C., Salah, E., Savitsky, P., Pantic, N., Gorrec, F., Bunkoczi, G., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2H63
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CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE A
Descriptor:Biliverdin reductase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kavanagh, K., Elkins, J., Ugochukwu, E., Guo, K., Pilka, E., Lukacik, P., Smee, C., Papagrigoriou, E., Bunkoczi, G., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-05-30
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human Biliverdin Reductase A
To be Published
2NZJ
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THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDP
Descriptor:GTP-binding protein REM 1, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Turnbull, A.P., Papagrigoriou, E., Ugochukwu, E., Elkins, J.M., Soundararajan, M., Yang, X., Gorrec, F., Umeano, C., Salah, E., Burgess, N., Johansson, C., Berridge, G., Gileadi, O., Bray, J., Marsden, B., Watts, S., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-11-23
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of REM1 in complex with GDP
To be Published
2NZL
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CRYSTAL STRUCTURE OF HUMAN HYDROXYACID OXIDASE 1
Descriptor:Hydroxyacid oxidase 1, FLAVIN MONONUCLEOTIDE, GLYOXYLIC ACID
Authors:Ugochukwu, E., Kavanagh, K., Pilka, E., Berridge, G., Debreczeni, J.E., Papagrigoriou, E., Turnbull, A., Niesen, F., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-11-24
Release date:2006-12-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of human hydroxyacid oxidase 1
To be Published
2OPG
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THE CRYSTAL STRUCTURE OF THE 10TH PDZ DOMAIN OF MPDZ
Descriptor:Multiple PDZ domain protein, SODIUM ION
Authors:Gileadi, C., Phillips, C., Elkins, J., Papagrigoriou, E., Ugochukwu, E., Gorrec, F., Savitsky, P., Umeano, C., Berridge, G., Gileadi, O., Salah, E., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-01-29
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of the 10th PDZ domain of MPDZ
To be Published
2PA1
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO A C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN
Descriptor:PDZ and LIM domain protein 2, CHLORIDE ION
Authors:Uppenberg, J., Shrestha, L., Elkins, J., Burgess-Brown, N., Salah, E., Bunkoczi, G., Papagrigoriou, E., Pike, A.C.W., Turnbull, A.P., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin.
To be Published