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cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MPE8 Single chain variable fragment, Structurally designed HMPV F protein HMPV_v3B_D12_DS454,Fibritin
Authors:	Zhou, T, Kwong, P.D, Morano, N.C, Ou, L.
Deposit date:	2022-11-17
Release date:	2023-08-02
Method:	ELECTRON MICROSCOPY (3.25 Å)
Cite:	cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 To Be Published

2DDY

Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor
Descriptor:	(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE, CALCIUM ION, Matrilysin, ...
Authors:	Zheng, X.H, Ou, L.
Deposit date:	2006-02-06
Release date:	2007-02-06
Last modified:	2024-05-29
Method:	SOLUTION NMR
Cite:	Solution Structure of Matrilysin (MMP-7) Complexed to Constraint Conformational Sulfonamide Inhibitor to be published

2Z2D

Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor
Descriptor:	(3R)-3-{4-[(4-CHLOROPHENYL)ETHYNYL]BENZOYL}NONANOIC ACID, CALCIUM ION, Macrophage metalloelastase, ...
Authors:	Zheng, X, Ou, L.
Deposit date:	2007-05-18
Release date:	2007-11-20
Last modified:	2024-05-29
Method:	SOLUTION NMR
Cite:	Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor To be published

6VZI

Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ...
Authors:	Lai, Y.-T, Kwong, P.D.
Deposit date:	2020-02-28
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.716 Å)
Cite:	Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses. J.Virol., 94, 2020

7SG5

Structure of PfCSP peptide 21 with antibody CIS43_Var2
Descriptor:	CIS43_Var2 Fab Heavy chain, CIS43_Var2 Fab Light chain, GLYCEROL, ...
Authors:	Tripathi, P, Kwong, P.D.
Deposit date:	2021-10-05
Release date:	2022-06-22
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Highly protective antimalarial antibodies via precision library generation and yeast display screening. J.Exp.Med., 219, 2022

7SG6

Structure of PfCSP peptide 21 with antibody CIS43_Var10
Descriptor:	CIS43_Var10 Fab Heavy chain, CIS43_Var10 Fab Light chain, GLYCEROL, ...
Authors:	Tripathi, P, Kwong, P.D.
Deposit date:	2021-10-05
Release date:	2022-06-22
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Highly protective antimalarial antibodies via precision library generation and yeast display screening. J.Exp.Med., 219, 2022

4HNJ

Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Fisher, J.C, Yun, M.K, White, S.W.
Deposit date:	2012-10-19
Release date:	2013-01-23
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

2M04

Solution structure of BCL-xL in complex with PUMA BH3 peptide
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

2M03

Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains
Descriptor:	Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

7LZE

Cryo-EM Structure of disulfide stabilized HMPV F v4-B
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2021-03-09
Release date:	2021-08-25
Last modified:	2021-10-06
Method:	ELECTRON MICROSCOPY (3.23 Å)
Cite:	Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses. Proc.Natl.Acad.Sci.USA, 118, 2021

7LKG

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.151
Descriptor:	Circumsporozoite protein, m43.151 Fab Heavy Chain, m43.151 Fab Light chain
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2021-02-02
Release date:	2021-12-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54, 2021

7LKB

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127
Descriptor:	Circumsporozoite protein, SULFATE ION, m42.127 Fab heavy Chain, ...
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2021-02-02
Release date:	2021-12-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54, 2021

7MTD

Structure of aged SARS-CoV-2 S2P spike at pH 7.4
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

7MTC

Structure of freshly purified SARS-CoV-2 S2P spike at pH 7.4
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (2.6 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

7MTE

Structure of SARS-CoV-2 S2P spike at pH 7.4 refolded by low-pH treatment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Tsybovsky, Y, Olia, A.S, Kwong, P.D.
Deposit date:	2021-05-13
Release date:	2021-09-15
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity. J.Biol.Chem., 297, 2021

5TKK

Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide residue 512-519, mouse antibody vFP5.01 heavy chain, mouse antibody vFP5.01 light chain
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2016-10-06
Release date:	2018-04-04
Last modified:	2018-06-27
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

5TKJ

Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide residue 512-519, SULFATE ION, vFP1.01 chimeric mouse antibody heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2016-10-06
Release date:	2018-04-04
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.118 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6CDE

Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ...
Authors:	Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6CDO

Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide 512-519, SULFATE ION, vFP16.02 Fab heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2018-06-20
Method:	X-RAY DIFFRACTION (2.099 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6CDP

Vaccine-elicited HIV-1 neutralizing antibody vFP20.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV-1 fusion peptide 512-519, SULFATE ION, vFP20.01 Fab heavy chain, ...
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2018-06-20
Method:	X-RAY DIFFRACTION (2.456 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6Q0S

Crystal Structure of RSV strain B18537 Prefusion-stabilized glycoprotein F Variant DS-Cav1
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, SULFATE ION
Authors:	Joyce, M.G, Bao, A, Kwong, P.D.
Deposit date:	2019-08-02
Release date:	2020-01-22
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B. Pathog Immun, 4, 2019

6UBI

N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor:	HIV fusion peptide 512-519, VRC34.05 heavy chain, VRC34.05 light chain
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2019-09-11
Release date:	2020-03-18
Last modified:	2020-04-22
Method:	X-RAY DIFFRACTION (1.903 Å)
Cite:	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host Microbe, 27, 2020

6CDI

Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ...
Authors:	Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6CDM

Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519
Descriptor:	HIV fusion peptide (512-519), vFP7.04 heavy chain, vFP7.04 light chain
Authors:	Xu, K, Liu, K, Kwong, P.D.
Deposit date:	2018-02-08
Release date:	2018-05-16
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.408 Å)
Cite:	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018

6UCE

N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor:	HIV fusion peptide, N123-VRC34_pI3 heavy chain, N123-VRC34_pI3 light chain
Authors:	Xu, K, Kwong, P.D.
Deposit date:	2019-09-16
Release date:	2020-03-18
Last modified:	2020-04-22
Method:	X-RAY DIFFRACTION (1.382 Å)
Cite:	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host Microbe, 27, 2020

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