Author results

1LTH
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T AND R STATES IN THE CRYSTALS OF BACTERIAL L-LACTATE DEHYDROGENASE REVEAL THE MECHANISM FOR ALLOSTERIC CONTROL
Descriptor:L-LACTATE DEHYDROGENASE (T- AND R- STATE TETRAMER COMPLEX), BETA-FRUCTOSE-1,6-DIPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Iwata, S., Ohta, T.
Deposit date:1995-01-04
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control.
Nat.Struct.Biol., 1, 1994
1LLD
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MOLECULAR BASIS OF ALLOSTERIC ACTIVATION OF BACTERIAL L-LACTATE DEHYDROGENASE
Descriptor:L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Iwata, S., Ohta, T.
Deposit date:1992-06-08
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase.
J.Mol.Biol., 230, 1993
3TK5
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FACTOR XA IN COMPLEX WITH D102-4380
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3TK6
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FACTOR XA IN COMPLEX WITH D46-5241
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
1X2J
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STRUCTURAL BASIS FOR THE DEFECTS OF HUMAN LUNG CANCER SOMATIC MUTATIONS IN THE REPRESSION ACTIVITY OF KEAP1 ON NRF2
Descriptor:Kelch-like ECH-associated protein 1, SULFATE ION
Authors:Padmanabhan, B., Tong, K.I., Nakamura, Y., Ohta, T., Scharlock, M., Kobayashi, A., Ohtsuji, M., Kang, M.-I., Yamamoto, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-25
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Mol.Cell, 21, 2006
1X2R
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STRUCTURAL BASIS FOR THE DEFECTS OF HUMAN LUNG CANCER SOMATIC MUTATIONS IN THE REPRESSION ACTIVITY OF KEAP1 ON NRF2
Descriptor:Kelch-like ECH-associated protein 1, Nuclear factor erythroid 2 related factor 2, SULFATE ION
Authors:Padmanabhan, B., Tong, K.I., Nakamura, Y., Ohta, T., Scharlock, M., Kobayashi, A., Ohtsuji, M., Kang, M.-I., Yamamoto, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-26
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Mol.Cell, 21, 2006
2DG0
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CRYSTAL STRUCTURE OF DRP35, A 35KDA DRUG RESPONSIVE PROTEIN FROM STAPHYLOCOCCUS AUREUS
Descriptor:DrP35
Authors:Tanaka, Y., Ohki, Y., Morikawa, K., Yao, M., Watanabe, N., Ohta, T., Tanaka, I.
Deposit date:2006-03-07
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Mutational Analyses of Drp35 from Staphylococcus aureus: A POSSIBLE MECHANISM FOR ITS LACTONASE ACTIVITY
J.Biol.Chem., 282, 2007
2DG1
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CRYSTAL STRUCTURE OF DRP35, A 35KDA DRUG RESPONSIVE PROTEIN FROM STAPHYLOCOCCUS AUREUS, COMPLEXED WITH CA2+
Descriptor:DrP35, CALCIUM ION, GLYCEROL
Authors:Tanaka, Y., Ohki, Y., Morikawa, K., Yao, M., Watanabe, N., Ohta, T., Tanaka, I.
Deposit date:2006-03-07
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural and Mutational Analyses of Drp35 from Staphylococcus aureus: A POSSIBLE MECHANISM FOR ITS LACTONASE ACTIVITY
J.Biol.Chem., 282, 2007
2DGJ
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CRYSTAL STRUCTURE OF EBHA (756-1003 DOMAIN) FROM STAPHYLOCOCCUS AUREUS
Descriptor:hypothetical protein ebhA, SULFATE ION, ACETIC ACID, ...
Authors:Tanaka, Y., Yao, M., Kuroda, M., Watanabe, N., Ohta, T., Tanaka, I.
Deposit date:2006-03-14
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus
Structure, 16, 2008
2DSO
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CRYSTAL STRUCTURE OF D138N MUTANT OF DRP35, A 35KDA DRUG RESPONSIVE PROTEIN FROM STAPHYLOCOCCUS AUREUS
Descriptor:Drp35, CALCIUM ION, GLYCEROL
Authors:Tanaka, Y., Ohki, Y., Morikawa, K., Yao, M., Watanabe, N., Ohta, T., Tanaka, I.
Deposit date:2006-07-04
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mutational Analyses of Drp35 from Staphylococcus aureus: A POSSIBLE MECHANISM FOR ITS LACTONASE ACTIVITY
J.Biol.Chem., 282, 2007
3ST7
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CRYSTAL STRUCTURE OF CAPSULAR POLYSACCHARIDE ASSEMBLING PROTEIN CAPF FROM STAPHYLOCOCCUS AUREUS
Descriptor:Capsular polysaccharide synthesis enzyme Cap5F, ZINC ION, GLYCEROL
Authors:Miyafusa, T., Tanaka, Y., Kuroda, M., Yao, M., Watanabe, M., Ohta, T., Tanaka, I., Caaveiro, J.M.M., Tsumoto, K.
Deposit date:2011-07-09
Release date:2012-02-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the enzyme CapF of Staphylococcus aureus reveals a unique architecture composed of two functional domains.
Biochem.J., 443, 2012
2E7A
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TNF RECEPTOR SUBTYPE ONE-SELECTIVE TNF MUTANT WITH ANTAGONISTIC ACTIVITY
Descriptor:Tumor necrosis factor
Authors:Mukai, Y., Yamagata, Y., Tsutsumi, Y.
Deposit date:2007-01-09
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
J.Biol.Chem., 283, 2008
2ZPX
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TNF RECEPTOR SUBTYPE ONE-SELECTIVE TNF MUTANT WITH ANTAGONISTIC ACTIVITY; R1ANTTNF-T8
Descriptor:Tumor necrosis factor
Authors:Mukai, Y., Nakamura, T., Yamagata, Y., Tsutsumi, Y.
Deposit date:2008-07-29
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists
J.Biochem., 146, 2009
2RQZ
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STRUCTURE OF SUGAR MODIFIED EPIDERMAL GROWTH FACTOR-LIKE REPEAT 12 OF MOUSE NOTCH-1 RECEPTOR
Descriptor:Neurogenic locus notch homolog protein 1, ALPHA-L-FUCOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Shimizu, K., Fujitani, N., Hosoguchi, K., Nishimura, S.
Deposit date:2010-02-26
Release date:2010-10-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor
J.Am.Chem.Soc., 132, 2010
2RR0
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STRUCTURE OF EPIDERMAL GROWTH FACTOR-LIKE REPEAT 12 OF MOUSE NOTCH-1 RECEPTOR
Descriptor:Neurogenic locus notch homolog protein 1
Authors:Hosoguchi, K., Shimizu, K., Fujitani, N., Nishimura, S.
Deposit date:2010-02-26
Release date:2010-10-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor
J.Am.Chem.Soc., 132, 2010
2RR2
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STRUCTURE OF O-FUCOSYLATED EPIDERMAL GROWTH FACTOR-LIKE REPEAT 12 OF MOUSE NOTCH-1 RECEPTOR
Descriptor:Neurogenic locus notch homolog protein 1, ALPHA-L-FUCOSE
Authors:Hosoguchi, K., Shimizu, K., Fujitani, N., Nishimura, S.
Deposit date:2010-02-26
Release date:2010-10-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor
J.Am.Chem.Soc., 132, 2010
2ZJC
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TNFR1 SELECTVE TNF MUTANT; R1-6
Descriptor:Tumor necrosis factor, GLYCEROL
Authors:Mukai, Y., Yamagata, Y., Tsutsumi, Y.
Deposit date:2008-03-05
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant
J.Mol.Biol., 385, 2009
2ZKL
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CRYSTAL STRUCTURE OF CAPSULAR POLYSACCHARIDE ASSEMBLING PROTEIN CAPF FROM STAPHYLOCOCCUS AUREUS
Descriptor:Capsular polysaccharide synthesis enzyme Cap5F, ZINC ION, GLYCEROL
Authors:Miyafusa, T., Tanaka, Y., Yao, M., Tanaka, I., Tsumoto, K.
Deposit date:2008-03-25
Release date:2009-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structure of capsular polysaccharide assembling protein from Staphylococcus aureus
to be published
3IIT
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FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
3Q3K
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FACTOR XA IN COMPLEX WITH A PHENYLENEDIAMINE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Imai, E.
Deposit date:2010-12-22
Release date:2011-12-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
1WV3
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF HYPOTHETICAL PROTEIN SAV0287 FROM STAPHYLOCOCCUS AUREUS
Descriptor:similar to DNA segregation ATPase and related proteins, CHLORIDE ION
Authors:Tanaka, Y., Yasutake, Y., Tanaka, I.
Deposit date:2004-12-10
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure analysis reveals a novel forkhead-associated domain of ESAT-6 secretion system C protein in Staphylococcus aureus.
Proteins, 69, 2007
2E7D
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CRYSTAL STRUCTURE OF A NEAT DOMAIN FROM STAPHYLOCOCCUS AUREUS
Descriptor:Hypothetical protein IsdH, SULFATE ION, ACETATE ION, ...
Authors:Suenaga, A., Tanaka, Y., Yao, M., Kumagai, I., Tanaka, I., Tsumoto, K.
Deposit date:2007-01-09
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for multimeric heme complexation through a specific protein-heme interaction: the case of the third neat domain of IsdH from Staphylococcus aureus
J.Biol.Chem., 283, 2008
2Z6F
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CRYSTAL STRUCTURE OF NEAT DOMAIN FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH HEME
Descriptor:Iron-regulated surface determinant protein H, PROTOPORPHYRIN IX CONTAINING FE
Authors:Tanaka, Y., Suenaga, A., Tsumoto, K.
Deposit date:2007-07-31
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for multimeric heme complexation through a specific protein-heme interaction: the case of the third neat domain of IsdH from Staphylococcus aureus
J.Biol.Chem., 283, 2008
3IRP
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CRYSTAL STRUCTURE OF FUNCTIONAL REGION OF UAFA FROM STAPHYLOCOCCUS SAPROPHYTICUS AT 1.50 ANGSTROM RESOLUTION
Descriptor:Uro-adherence factor A, GLYCEROL, POTASSIUM ION
Authors:Tanaka, Y., Shouji, Y., Matsuoka, E., Kuroda, M., Tanaka, I., Yao, M.
Deposit date:2009-08-24
Release date:2010-09-08
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the functional region of Uro-adherence factor A from Staphylococcus saprophyticus reveals participation of the B domain in ligand binding
Protein Sci., 20, 2011
3IRZ
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CRYSTAL STRUCTURE OF FUNCTIONAL REGION OF UAFA FROM STAPHYLOCOCCUS SAPROPHYTICUS IN P212121 FORM
Descriptor:Uro-adherence factor A, GLYCEROL
Authors:Tanaka, Y., Shouji, Y., Matsuoka, E., Kuroda, M., Tanaka, I., Yao, M.
Deposit date:2009-08-24
Release date:2010-09-08
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the functional region of Uro-adherence factor A from Staphylococcus saprophyticus reveals participation of the B domain in ligand binding
Protein Sci., 20, 2011
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