Author results

2BG5
  • Download 2bg5
  • View 2bg5
Molmil generated image of 2bg5
CRYSTAL STRUCTURE OF THE PHOSPHOENOLPYRUVATE-BINDING ENZYME I-DOMAIN FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP: SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)
Descriptor:PHOSPHOENOLPYRUVATE-PROTEIN KINASE
Authors:Oberholzer, A.E., Bumann, M., Schneider, P., Baechler, C., Siebold, C., Baumann, U., Erni, B.
Deposit date:2004-12-17
Release date:2005-02-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Phosphoenolpyruvate-Binding Enzyme I-Domain from the Thermoanaerobacter Tengcongensis Pep: Sugar Phosphotransferase System (Pts)
J.Mol.Biol., 346, 2005
2BTD
  • Download 2btd
  • View 2btd
Molmil generated image of 2btd
CRYSTAL STRUCTURE OF DHAL FROM E. COLI
Descriptor:PTS-DEPENDENT DIHYDROXYACETONE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Oberholzer, A.E., Schneider, P., Bachler, C., Baumann, U., Erni, B.
Deposit date:2005-05-27
Release date:2006-06-22
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Nucleotide-Binding Subunit Dhal of the Escherichia Coli Dihydroxyacetone Kinase.
J.Mol.Biol., 359, 2006
2WQD
  • Download 2wqd
  • View 2wqd
Molmil generated image of 2wqd
CRYSTAL STRUCTURE OF ENZYME I OF THE PHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE
Descriptor:PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE, CALCIUM ION
Authors:Oberholzer, A.E., Schneider, P., Siebold, C., Baumann, U., Erni, B.
Deposit date:2009-08-19
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System in the Dephosphorylated State.
J.Biol.Chem., 284, 2009
3HB2
  • Download 3hb2
  • View 3hb2
Molmil generated image of 3hb2
PRTC METHIONINE MUTANTS: M226I
Descriptor:Secreted protease C, CALCIUM ION, ZINC ION, ...
Authors:Oberholzer, A.E., Bumann, M., Hege, T., Russo, S., Baumann, U.
Deposit date:2009-05-04
Release date:2009-08-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
Biol.Chem., 390, 2009
3HBU
  • Download 3hbu
  • View 3hbu
Molmil generated image of 3hbu
PRTC METHIONINE MUTANTS: M226H DESY
Descriptor:Secreted protease C, peptide, CALCIUM ION, ...
Authors:Oberholzer, A.E., Bumann, M., Hege, T., Russo, S., Baumann, U.
Deposit date:2009-05-05
Release date:2009-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
Biol.Chem., 390, 2009
3HBV
  • Download 3hbv
  • View 3hbv
Molmil generated image of 3hbv
PRTC METHIONINE MUTANTS: M226A IN-HOUSE
Descriptor:Secreted protease C, Uncharacterized peptide, CALCIUM ION, ...
Authors:Oberholzer, A.E., Bumann, M., Hege, T., Russo, S., Baumann, U.
Deposit date:2009-05-05
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
Biol.Chem., 390, 2009
3HDA
  • Download 3hda
  • View 3hda
Molmil generated image of 3hda
PRTC METHIONINE MUTANTS: M226A_DESY
Descriptor:Secreted protease C, Uncharacterized peptide, CALCIUM ION, ...
Authors:Oberholzer, A.E., Bumann, M., Hege, T., Russo, S., Baumann, U.
Deposit date:2009-05-07
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.131 Å)
Cite:Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
Biol.Chem., 390, 2009
4AZ9
  • Download 4az9
  • View 4az9
Molmil generated image of 4az9
CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 24
Descriptor:SORTING NEXIN-24, 1,2-ETHANEDIOL
Authors:Oberholzer, A.E., Kiyani, W., Krojer, T., Shrestha, L., von Delft, F., Froese, D.S., Chaikuad, A., Raynor, J., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-06-24
Release date:2012-10-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Phox Homology Domain of Human Sorting Nexin 24
To be Published
4BN6
  • Download 4bn6
  • View 4bn6
Molmil generated image of 4bn6
NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH CHLORAMPHENICOL
Descriptor:COPPER INDUCED NITROREDUCTASE D, FLAVIN MONONUCLEOTIDE, CHLORAMPHENICOL
Authors:Oberholzer, A.E., Baumgartner, R., Waltersperger, S.
Deposit date:2013-05-13
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.462 Å)
Cite:Nitroreductase Cind from Lactococcus Lactis in Complex with Chloramphenicol
To be Published
4BN8
  • Download 4bn8
  • View 4bn8
Molmil generated image of 4bn8
NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH 4- NITROPHENOL
Descriptor:COPPER INDUCED NITROREDUCTASE D, FLAVIN MONONUCLEOTIDE, P-NITROPHENOL
Authors:Oberholzer, A.E., Waltersperger, S., Baumgartner, R.
Deposit date:2013-05-13
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Nitroreductase Cind from Lactococcus Lactis
To be Published
2XZ9
  • Download 2xz9
  • View 2xz9
Molmil generated image of 2xz9
CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)
Descriptor:PHOSPHOENOLPYRUVATE-PROTEIN KINASE (PTS SYSTEM EI COMPONENT IN BACTERIA), MAGNESIUM ION, PYRUVIC ACID
Authors:Oberholzer, A.E., Waltersperger, S.M., Schneider, P., Baumann, U., Erni, B.
Deposit date:2010-11-24
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.677 Å)
Cite:Phosphoenolpyruvate: Sugar Phosphotransferase System from the Hyperthermophilic Thermoanaerobacter Tengcongensis.
Biochemistry, 50, 2011
3ZDI
  • Download 3zdi
  • View 3zdi
Molmil generated image of 3zdi
GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE AND INHIBITOR 7D
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, PHOSPHATE ION, ...
Authors:Oberholzer, A.E., Pearl, L.H.
Deposit date:2012-11-27
Release date:2012-12-26
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3)
J.Med.Chem., 56, 2013
4B7T
  • Download 4b7t
  • View 4b7t
Molmil generated image of 4b7t
GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE AND LEUCETTINE L4
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one
Authors:Oberholzer, A.E., Pearl, L.H.
Deposit date:2012-08-22
Release date:2013-01-30
Method:X-RAY DIFFRACTION (2.772 Å)
Cite:Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
1W2W
  • Download 1w2w
  • View 1w2w
Molmil generated image of 1w2w
CRYSTAL STRUCTURE OF YEAST YPR118W, A METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE RELATED TO REGULATORY EIF2B SUBUNITS
Descriptor:5-METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE, SULFATE ION
Authors:Bumann, M., Djafarzadeh, S., Oberholzer, A.E., Bigler, P., Altmann, M., Trachsel, H., Baumann, U.
Deposit date:2004-07-09
Release date:2004-07-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Yeast Ypr118W, a Methylthioribose-1-Phosphate Isomerase Related to Regulatory Eif2B Subunits
J.Biol.Chem., 279, 2004
2VSO
  • Download 2vso
  • View 2vso
Molmil generated image of 2vso
CRYSTAL STRUCTURE OF A TRANSLATION INITIATION COMPLEX
Descriptor:ATP-DEPENDENT RNA HELICASE EIF4A, EUKARYOTIC INITIATION FACTOR 4F SUBUNIT P150, ADENOSINE MONOPHOSPHATE
Authors:Schutz, P., Bumann, M., Oberholzer, A.E., Bieniossek, C., Altmann, M., Trachsel, H., Baumann, U.
Deposit date:2008-04-28
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Yeast Eif4A-Eif4G Complex: An RNA-Helicase Controlled by Protein-Protein Interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
2VSX
  • Download 2vsx
  • View 2vsx
Molmil generated image of 2vsx
CRYSTAL STRUCTURE OF A TRANSLATION INITIATION COMPLEX
Descriptor:ATP-DEPENDENT RNA HELICASE EIF4A, EUKARYOTIC INITIATION FACTOR 4F SUBUNIT P150, ADENOSINE MONOPHOSPHATE
Authors:Schutz, P., Bumann, M., Oberholzer, A.E., Bieniossek, C., Altmann, M., Trachsel, H., Baumann, U.
Deposit date:2008-04-30
Release date:2008-06-24
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Yeast Eif4A-Eif4G Complex: An RNA-Helicase Controlled by Protein-Protein Interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
2WQF
  • Download 2wqf
  • View 2wqf
Molmil generated image of 2wqf
CRYSTAL STRUCTURE OF THE NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH FMN
Descriptor:COPPER INDUCED NITROREDUCTASE D, FLAVIN MONONUCLEOTIDE
Authors:Waltersperger, S.M., Oberholzer, A.E., Solioz, M., Baumann, U.
Deposit date:2009-08-20
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure and Function of Cind (Ytjd) of Lactococcus Lactis, a Copper-Induced Nitroreductase Involved in Defense Against Oxidative Stress.
J.Bacteriol., 192, 2010
2XZ7
  • Download 2xz7
  • View 2xz7
Molmil generated image of 2xz7
CRYSTAL STRUCTURE OF THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PHOSPHOENOLPYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)
Descriptor:PHOSPHOENOLPYRUVATE-PROTEIN KINASE (PTS SYSTEM EI COMPONENT IN BACTERIA), PHOSPHOENOLPYRUVATE, MAGNESIUM ION
Authors:Waltersperger, S.M., Oberholzer, A.E., Schneider, P., Baumann, U., Erni, B.
Deposit date:2010-11-23
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Phosphoenolpyruvate: Sugar Phosphotransferase System from the Hyperthermophilic Thermoanaerobacter Tengcongensis.
Biochemistry, 50, 2011
4BN7
  • Download 4bn7
  • View 4bn7
Molmil generated image of 4bn7
NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH 2,6- DICHLOROPHENOLINDOPHENOL
Descriptor:COPPER INDUCED NITROREDUCTASE D, FLAVIN MONONUCLEOTIDE, 2,6-bis(chloranyl)-4-[(4-hydroxyphenyl)amino]phenol
Authors:Waltersperger, S., Baumgartner, R., Oberholzer, A.E.
Deposit date:2013-05-13
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.723 Å)
Cite:Nitroreductase Cind from Lactococcus Lactis
To be Published
4BN9
  • Download 4bn9
  • View 4bn9
Molmil generated image of 4bn9
NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH NICOTINIC ACID
Descriptor:COPPER INDUCED NITROREDUCTASE D, NICOTINIC ACID, FLAVIN MONONUCLEOTIDE
Authors:Baumgartner, R., Waltersperger, S., Oberholzer, A.E.
Deposit date:2013-05-13
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2.084 Å)
Cite:Nitroreductase Cind from Lactococcus Lactis
To be Published
4BNB
  • Download 4bnb
  • View 4bnb
Molmil generated image of 4bnb
NITROREDUCTASE CIND FROM LACTOCOCCUS LACTIS IN COMPLEX WITH 4- NITROQUINOLINE 1-OXIDE
Descriptor:COPPER INDUCED NITROREDUCTASE D, FLAVIN MONONUCLEOTIDE, 4-NITROQUINOLINE 1-OXIDE
Authors:Waltersperger, S., Oberholzer, A.E., Baumgartner, R.
Deposit date:2013-05-13
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.478 Å)
Cite:Nitroreductase Cind from Lactococcus Lactis in Complex with 2 4-Nitroquinoline 1-Oxidenone
To be Published
5MPO
  • Download 5mpo
  • View 5mpo
Molmil generated image of 5mpo
CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE COMPLEX
Descriptor:Molybdopterin synthase sulfur carrier subunit, Molybdopterin synthase catalytic subunit
Authors:Kopec, J., Bailey, H., Fitzpatrick, F., Strain-Damerell, C., Oberholzer, A.E., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-12-16
Release date:2016-12-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of human molybdopterin synthase complex
To Be Published
6FCX
  • Download 6fcx
  • View 6fcx
Molmil generated image of 6fcx
STRUCTURE OF HUMAN 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR)
Descriptor:Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Kopec, J., Bezerra, G.A., Oberholzer, A.E., Rembeza, E., Sorrell, F.J., Chalk, R., Borkowska, O., Ellis, K., Kupinska, K., Krojer, T., Burgess-Brown, N., Von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-12-21
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018
4GW8
  • Download 4gw8
  • View 4gw8
Molmil generated image of 4gw8
HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND LEUCETTINE L41
Descriptor:Serine/threonine-protein kinase pim-1, Consensus peptide (Pimtide), 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, ...
Authors:Filippakopoulos, P., Bullock, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Meijer, L., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2012-09-01
Release date:2012-10-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
J.Med.Chem., 55, 2012
6FNU
  • Download 6fnu
  • View 6fnu
Molmil generated image of 6fnu
STRUCTURE OF S. CEREVISIAE METHYLENETETRAHYDROFOLATE REDUCTASE 1, CATALYTIC DOMAIN
Descriptor:Methylenetetrahydrofolate reductase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kopec, J., Rembeza, E., Bezerra, G.A., Newman, J., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-07
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9, 2018