6FCX
Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)
Summary for 6FCX
Entry DOI | 10.2210/pdb6fcx/pdb |
Descriptor | Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
Functional Keywords | one carbon metabolism, rossmann fold, s-adenosyl-methionine, structural genomics, structural genomics consortium, sgc, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 143826.15 |
Authors | Kopec, J.,Bezerra, G.A.,Oberholzer, A.E.,Rembeza, E.,Sorrell, F.J.,Chalk, R.,Borkowska, O.,Ellis, K.,Kupinska, K.,Krojer, T.,Burgess-Brown, N.,Von Delft, F.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Froese, D.S.,Baumgartner, M.,Yue, W.W.,Structural Genomics Consortium (SGC) (deposition date: 2017-12-21, release date: 2018-05-16, Last modification date: 2018-07-04) |
Primary citation | Froese, D.S.,Kopec, J.,Rembeza, E.,Bezerra, G.A.,Oberholzer, A.E.,Suormala, T.,Lutz, S.,Chalk, R.,Borkowska, O.,Baumgartner, M.R.,Yue, W.W. Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Nat Commun, 9:2261-2261, 2018 Cited by PubMed: 29891918DOI: 10.1038/s41467-018-04735-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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