6FCX

Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methylenetetrahydrofolate reductase	polymer	615	70551.0	2	UniProt (P42898) Pfam (PF02219) Pfam (PF21895)	Homo sapiens (Human)
2	C, F (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	D, G (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
4	E, H (A, B)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT) PubChem (311)
5	I, J (A, B)	water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B: 37 - 644 (UniProt: P42898)

PDB	External Database	Details
Met 37	Leu 37	initiating methionine
Ala 429	Glu 429	variant
Gln 594	Arg 594	variant
Ala 645	-	expression tag
Glu 646	-	expression tag
Asn 647	-	expression tag
Leu 648	-	expression tag
Tyr 649	-	expression tag
Phe 650	-	expression tag
Gln 651	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	141102.0
Non-Polymers*	Number of molecules	6
	Total formula weight	2724.2
All*	Total formula weight	143826.2

*Water molecules are not included.