6FCX

Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Methylenetetrahydrofolate reductase	polymer	615	70551.0	2	UniProt (P42898) Pfam (PF02219) Pfam (PF21895) In PDB	Homo sapiens (Human)
2	A, B	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	A, B	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	A, B	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
5		water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B: 37 - 644 (UniProt: P42898)

PDB	External Database	Details
Met 37	Leu 37	initiating methionine
Ala 429	Glu 429	variant
Gln 594	Arg 594	variant
Ala 645	-	expression tag
Glu 646	-	expression tag
Asn 647	-	expression tag
Leu 648	-	expression tag
Tyr 649	-	expression tag
Phe 650	-	expression tag
Gln 651	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	141102.0
Non-Polymers*	Number of molecules	6
	Total formula weight	2724.2
All*	Total formula weight	143826.2

*Water molecules are not included.