6FCX
Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Methylenetetrahydrofolate reductase | polymer | 615 | 70551.0 | 2 | UniProt (P42898) Pfam (PF02219) Pfam (PF21895) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, G (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | E, H (A, B) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 37 - 644 (UniProt: P42898)
| PDB | External Database | Details |
|---|---|---|
| Met 37 | Leu 37 | initiating methionine |
| Ala 429 | Glu 429 | variant |
| Gln 594 | Arg 594 | variant |
| Ala 645 | - | expression tag |
| Glu 646 | - | expression tag |
| Asn 647 | - | expression tag |
| Leu 648 | - | expression tag |
| Tyr 649 | - | expression tag |
| Phe 650 | - | expression tag |
| Gln 651 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 141102.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2724.2 | |
| All* | Total formula weight | 143826.2 |
