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4GW8

Human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and Leucettine L41

Summary for 4GW8
Entry DOI10.2210/pdb4gw8/pdb
DescriptorSerine/threonine-protein kinase pim-1, Consensus peptide (Pimtide), 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, ... (5 entities in total)
Functional Keywordsoncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence, cell cycle, cell membrane
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains2
Total formula weight37552.72
Authors
Filippakopoulos, P.,Bullock, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Meijer, L.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2012-09-01, release date: 2012-10-03, Last modification date: 2023-09-13)
Primary citationTahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.E.,Pearl, L.H.,Carreaux, F.,Bazureau, J.P.,Knapp, S.,Meijer, L.
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
J.Med.Chem., 55:9312-9330, 2012
Cited by
PubMed: 22998443
DOI: 10.1021/jm301034u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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