Author results

5YFM
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HUMAN ISOCITRATE DEHYDROGENASE 1 BOUND WITH NADP
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION
Authors:Nordlund, P., Chen, D., Jansson, A., Larsson, A.
Deposit date:2017-09-21
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human isocitrate dehydrogenase 1 bound with NADP
To Be Published
5YFN
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HUMAN ISOCITRATE DEHYDROGENASE 1 BOUND WITH ISOCITRATE
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, ISOCITRIC ACID, ...
Authors:Nordlund, P., Chen, D., Jansson, A., Larsson, A.
Deposit date:2017-09-21
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human isocitrate dehydrogenase 1 bound with isocitrate
To Be Published
2VKQ
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE III (CN-III, NT5C3) IN COMPLEX WITH BERYLLIUM TRIFLUORIDE
Descriptor:CYTOSOLIC 5'-NUCLEOTIDASE III, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION
Authors:Wallden, K., Moche, M., Arrowsmith, C.H., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-12-21
Release date:2008-01-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase III
To be Published
1BIQ
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RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A
Descriptor:PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE, FE (II) ION, FE (III) ION, ...
Authors:Logan, D.T., Demare, F., Persson, B.O., Slaby, A., Sjoberg, B.M., Nordlund, P.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.
Biochemistry, 37, 1998
1MRR
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SUBSTITUTION OF MANGANESE FOR IRON IN RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA COLI. SPECTROSCOPIC AND CRYSTALLOGRAPHIC CHARACTERIZATION
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, MANGANESE (II) ION, MERCURY (II) ION
Authors:Eklund, H., Nordlund, P.
Deposit date:1992-07-28
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substitution of manganese for iron in ribonucleotide reductase from Escherichia coli. Spectroscopic and crystallographic characterization.
J.Biol.Chem., 267, 1992
1MTY
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METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH)
Descriptor:METHANE MONOOXYGENASE HYDROXYLASE, FE (III) ION
Authors:Rosenzweig, A.C., Nordlund, P., Lippard, S.J., Frederick, C.A.
Deposit date:1996-07-10
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins, 29, 1997
1PFR
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RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN
Descriptor:PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE, FE (III) ION, MERCURY (II) ION
Authors:Logan, D.T., Su, X.D., Aberg, A., Regnstrom, K., Hajdu, J., Eklund, H., Nordlund, P.
Deposit date:1996-12-03
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.
Structure, 4, 1996
1PHR
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THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE
Descriptor:LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE, SULFATE ION
Authors:Su, X.-D., Taddei, N., Stefani, M., Ramponi, G., Nordlund, P.
Deposit date:1994-07-05
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase.
Nature, 370, 1994
1XIK
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RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN
Descriptor:PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE, FE (II) ION, MERCURY (II) ION
Authors:Logan, D.T., Su, X.-D., Aberg, A., Regnstrom, K., Hajdu, J., Eklund, H., Nordlund, P.
Deposit date:1996-08-06
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.
Structure, 4, 1996
2BW0
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CRYSTAL STRUCTURE OF THE HYDROLASE DOMAIN OF HUMAN 10-FORMYLTETRAHYDROFOLATE 2 DEHYDROGENASE
Descriptor:10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION
Authors:Ogg, D.J., Stenmark, P., Arrowsmith, C., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Dobritzsch, D., Weigelt, J.
Deposit date:2005-07-07
Release date:2005-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62, 2006
2BZN
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CRYSTAL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE 2 GMPR2 IN COMPLEX WITH IMP
Descriptor:GMP REDUCTASE 2, INOSINIC ACID
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, B.M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Weigelt, J.
Deposit date:2005-08-19
Release date:2005-09-02
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.
Nat.Chem.Biol., 7, 2011
2C4K
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CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE- ASSOCIATED PROTEIN 39 (PAP39)
Descriptor:PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 1, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Kursula, P., Stenmark, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2005-10-20
Release date:2005-10-24
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of Human Phosphoribosylpyrophosphate Synthetase-Associated Protein 39 (Pap39)
To be Published
2C6Q
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CRYSTAL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE 2 GMPR2 IN COMPLEX WITH IMP AND NADPH
Descriptor:GMP REDUCTASE 2, INOSINIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kursula, P., Stenmark, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, B.M., Kotenyova, T., Nilsson-Ehle, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Weigelt, J., Nordlund, P.
Deposit date:2005-11-11
Release date:2005-11-30
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.
Nat.Chem.Biol., 7, 2011
2CAR
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CRYSTAL STRUCTURE OF HUMAN INOSINE TRIPHOSPHATASE
Descriptor:INOSINE TRIPHOSPHATE PYROPHOSPHATASE
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Hogbom, M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2005-12-22
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
J.Biol.Chem., 282, 2007
2CFI
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THE HYDROLASE DOMAIN OF HUMAN 10-FTHFD IN COMPLEX WITH 6- FORMYLTETRAHYDROPTERIN
Descriptor:10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION, 6-FORMYLTETRAHYDROPTERIN
Authors:Kursula, P., Stenmark, P., Arrowsmith, C., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Ogg, D.J., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Weigelt, J.
Deposit date:2006-02-21
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62, 2006
2F73
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CRYSTAL STRUCTURE OF HUMAN FATTY ACID BINDING PROTEIN 1 (FABP1)
Descriptor:Fatty acid-binding protein, liver
Authors:Kursula, P., Thorsell, A.G., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., van den Berg, S., Weigelt, J., Hallberg, B.M., Structural Genomics Consortium (SGC)
Deposit date:2005-11-30
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human FABP1
To be Published
2FIM
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STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKE PROTEIN 1
Descriptor:Tubby related protein 1, 3-(N,N-DIMETHYLOCTYLAMMONIO)PROPANESULFONATE, SULFATE ION
Authors:Hallberg, B.M., Ogg, D., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Persson, C.
Deposit date:2005-12-29
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the C-terminal domain of Human Tubby-like protein 1
To be published
2FVZ
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HUMAN INOSITOL MONOPHOSPHOSPHATASE 2
Descriptor:Inositol monophosphatase 2
Authors:Ogg, D., Hallberg, B.M., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Van Den Berg, S., Weigelt, J., Thorsell, A.G., Structural Genomics Consortium (SGC)
Deposit date:2006-01-31
Release date:2006-02-21
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human Inositol Monophosphatase 2
To be published
2GSE
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CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINEASE-LIKE 2
Descriptor:Dihydropyrimidinase-related protein 2, CALCIUM ION
Authors:Ogg, D., Stenmark, P., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hallberg, B.M., Hammarstrom, M., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Holmberg-Schiavone, L., Thorsell, A.G., Uppenberg, J., Van Den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2006-04-26
Release date:2006-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of human collapsin response mediator protein 2, a regulator of axonal growth.
J.Neurochem., 101, 2007
2J2C
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, SULFATE ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Loppnau, P., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-08-16
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2J4E
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THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE
Descriptor:INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmbergschiavone, L., Hogbom, M., Kotenyova, T., Landry, R., Loppnau, P., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Schuler, H., Van Den Berg, S., Wallden, K., Weigelt, J., Nordlund, P.
Deposit date:2006-08-29
Release date:2006-09-20
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
J.Biol.Chem., 282, 2007
2JC9
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ADENOSINE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg, S.L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-21
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JCM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH BERYLLIUM TRIFLUORIDE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, UNKNOWN ATOM OR ION, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-27
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2VO1
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CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE
Descriptor:CTP SYNTHASE 1, SULFATE ION
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Kotenyoa, T., Moche, M., Nilsson-Ehle, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2008-02-08
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Synthetase Domain of Human Ctp Synthetase, a Target for Anticancer Therapy.
Acta Crystallogr.,Sect.F, 62, 2006
2XJD
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH INORGANIC PHOSPHATE AND DEOXYADENOSINE TRIPHOSPHATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-04
Release date:2011-04-27
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II.
J.Mol.Biol., 408, 2011
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