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6A22
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BU of 6a22 by Molmil
Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.
Descriptor: 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2
Authors:Noguchi, M, Nomura, A, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2018-06-08
Release date:2018-12-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
Sci Rep, 8, 2018
5X8U
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BU of 5x8u by Molmil
Crystal Structure of the wild Human ROR gamma Ligand Binding Domain.
Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1
Authors:Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8Q
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BU of 5x8q by Molmil
Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.
Descriptor: (1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-10,16-diol, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2
Authors:Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8W
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BU of 5x8w by Molmil
Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain.
Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1
Authors:Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8X
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BU of 5x8x by Molmil
Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.
Descriptor: (3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2
Authors:Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8S
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BU of 5x8s by Molmil
Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid.
Descriptor: Nuclear receptor ROR-gamma, Ursolic acid
Authors:Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
6IVX
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BU of 6ivx by Molmil
Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
Descriptor: (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2
Authors:Noguchi, M, Nomura, A, Doi, S, Adachi, T.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
J. Med. Chem., 62, 2019
5AYG
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BU of 5ayg by Molmil
Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g
Descriptor: 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide, Nuclear receptor ROR-gamma
Authors:Noguchi, M, Doi, S, Nomura, A, Kikuwaka, M, Murase, K, Hirata, K, Kamada, M, Adachi, T.
Deposit date:2015-08-20
Release date:2016-03-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Acs Med.Chem.Lett., 7, 2016
1IRM
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BU of 1irm by Molmil
Crystal structure of apo heme oxygenase-1
Descriptor: apo heme oxygenase-1
Authors:Sugishima, M, Sakamoto, H, Kakuta, Y, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K.
Deposit date:2001-10-09
Release date:2002-07-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms
Biochemistry, 41, 2002
4G7L
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BU of 4g7l by Molmil
Crystal Structure of rat Heme oxygenase-1 in complex with Heme and O2
Descriptor: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G99
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BU of 4g99 by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO at 100 K after warming to 160 K
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
1VGI
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BU of 1vgi by Molmil
Crystal structure of xenon bound rat heme-heme oxygenase-1 complex
Descriptor: FORMIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K.
Deposit date:2004-04-26
Release date:2004-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
1IX4
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BU of 1ix4 by Molmil
Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide
Descriptor: CARBON MONOXIDE, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K.
Deposit date:2002-06-10
Release date:2003-09-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1IX3
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BU of 1ix3 by Molmil
Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Cyanide
Descriptor: CYANIDE ION, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K.
Deposit date:2002-06-10
Release date:2003-09-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1DVE
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BU of 1dve by Molmil
CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME
Descriptor: HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K.
Deposit date:2000-01-20
Release date:2000-04-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
4G8W
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BU of 4g8w by Molmil
Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser on
Descriptor: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G7T
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BU of 4g7t by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination: Laser on
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G98
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BU of 4g98 by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO at 100K
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G8U
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BU of 4g8u by Molmil
Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser off
Descriptor: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G7P
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BU of 4g7p by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination at 100 K: Laser off
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G8P
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BU of 4g8p by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser on
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
4G7U
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BU of 4g7u by Molmil
Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser off
Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ...
Authors:Sugishima, M, Moffat, K, Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2022-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis.
Biochemistry, 51, 2012
1UBB
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BU of 1ubb by Molmil
Crystal structure of rat HO-1 in complex with ferrous heme
Descriptor: Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M, Sakamoto, H, Higashimoto, Y, Noguchi, M, Fukuyama, K.
Deposit date:2003-04-03
Release date:2003-09-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1ULX
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BU of 1ulx by Molmil
Partially photolyzed structure of CO-bound heme-heme oxygenase complex
Descriptor: CARBON MONOXIDE, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K.
Deposit date:2003-09-16
Release date:2004-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
1J2C
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BU of 1j2c by Molmil
Crystal structure of rat heme oxygenase-1 in complex with biliverdin IXalpha-iron cluster
Descriptor: BILIVERDINE IX ALPHA, FE (III) ION, Heme Oxygenase-1
Authors:Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K.
Deposit date:2002-12-29
Release date:2003-09-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Rat Heme Oxygenase-1 in Complex with Biliverdin-Iron Chelate: CONFORMATIONAL CHANGE OF THE DISTAL HELIX DURING THE HEME CLEAVAGE REACTION.
J.Biol.Chem., 278, 2003

 

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