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5X8Q
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CRYSTAL STRUCTURE OF THE MUTANT HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH ROCKOGENIN.
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-10,16-diol
Authors:Noguchi, M., Nomura, A., Murase, K., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8S
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CRYSTAL STRUCTURE OF THE MUTANT HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH URSOLIC ACID.
Descriptor:Uncharacterized protein, Ursolic acid
Authors:Noguchi, M., Nomura, A., Murase, K., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8U
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CRYSTAL STRUCTURE OF THE WILD HUMAN ROR GAMMA LIGAND BINDING DOMAIN.
Descriptor:Uncharacterized protein, Nuclear receptor coactivator 1
Authors:Noguchi, M., Nomura, A., Murase, K., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8W
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CRYSTAL STRUCTURE OF THE MUTANT HUMAN ROR GAMMA LIGAND BINDING DOMAIN.
Descriptor:Uncharacterized protein, Nuclear receptor coactivator 1
Authors:Noguchi, M., Nomura, A., Murase, K., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
5X8X
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CRYSTAL STRUCTURE OF THE MUTANT HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH COMPOUND A.
Descriptor:Uncharacterized protein, Nuclear receptor corepressor 2, (3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide
Authors:Noguchi, M., Nomura, A., Murase, K., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2017-03-03
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Genes Cells, 22, 2017
6A22
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TERNARY COMPLEX OF HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH COMPOUND T.
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide
Authors:Noguchi, M., Nomura, A., Doi, S., Yamaguchi, K., Adachi, T.
Deposit date:2018-06-08
Release date:2018-12-12
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
Sci Rep, 8, 2018
5AYG
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CRYSTAL STRUCTURE OF THE HUMAN ROR GAMMA LIGAND BINDING DOMAIN WITH 3G
Descriptor:Nuclear receptor ROR-gamma, 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide
Authors:Noguchi, M., Doi, S., Nomura, A., Kikuwaka, M., Murase, K., Hirata, K., Kamada, M., Adachi, T.
Deposit date:2015-08-20
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Acs Med.Chem.Lett., 7, 2016
6IVX
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DISCOVERY OF THE SECOND GENERATION ROR GAMMA INHIBITORS COMPOSED OF AN AZOLE SCAFFOLD.
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid
Authors:Noguchi, M., Nomura, A., Doi, S., Adachi, T.
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
J. Med. Chem., 2019
1IRM
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CRYSTAL STRUCTURE OF APO HEME OXYGENASE-1
Descriptor:apo heme oxygenase-1
Authors:Sugishima, M., Sakamoto, H., Kakuta, Y., Omata, Y., Hayashi, S., Noguchi, M., Fukuyama, K.
Deposit date:2001-10-09
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms
Biochemistry, 41, 2002
1DVE
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME
Descriptor:HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M., Omata, Y., Kakuta, Y., Sakamoto, H., Noguchi, M., Fukuyama, K.
Deposit date:2000-01-20
Release date:2000-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
1IX3
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME BOUND TO CYANIDE
Descriptor:HEME OXYGENASE-1, CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M., Sakamoto, H., Omata, Y., Hayashi, S., Noguchi, M., Fukuyama, K.
Deposit date:2002-06-10
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1IX4
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME BOUND TO CARBON MONOXIDE
Descriptor:HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Sugishima, M., Sakamoto, H., Omata, Y., Hayashi, S., Noguchi, M., Fukuyama, K.
Deposit date:2002-06-10
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1DVG
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME; SELELENO-METHIONINE DERIVATIVE, MUTATED AT M51T,M93L,M155L,M191L.
Descriptor:HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M., Omata, Y., Kakuta, Y., Sakamoto, H., Noguchi, M., Fukuyama, K.
Deposit date:2000-01-20
Release date:2000-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
1IVJ
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CRYSTAL STRUCTURE OF RAT HEMEOXYGENASE-1 IN COMPLEX WITH HEME AND AZIDE.
Descriptor:Hemeoxygenase-1, AZIDE ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M., Sakamoto, H., Omata, Y., Hayashi, S., Noguchi, M., Fukuyama, K.
Deposit date:2002-03-18
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Rat Heme Oxygenase-1 in Complex with Heme Bound to Azide. IMPLICATION FOR REGIOSPECIFIC HYDROXYLATION OF HEME AT THE alpha -MESO CARBON
J.Biol.Chem., 277, 2002
1J2C
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH BILIVERDIN IXALPHA-IRON CLUSTER
Descriptor:Heme Oxygenase-1, FE (III) ION, BILIVERDINE IX ALPHA
Authors:Sugishima, M., Sakamoto, H., Noguchi, M., Fukuyama, K.
Deposit date:2002-12-29
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Rat Heme Oxygenase-1 in Complex with Biliverdin-Iron Chelate: CONFORMATIONAL CHANGE OF THE DISTAL HELIX DURING THE HEME CLEAVAGE REACTION.
J.Biol.Chem., 278, 2003
1UBB
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CRYSTAL STRUCTURE OF RAT HO-1 IN COMPLEX WITH FERROUS HEME
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sugishima, M., Sakamoto, H., Higashimoto, Y., Noguchi, M., Fukuyama, K.
Deposit date:2003-04-03
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
1ULX
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PARTIALLY PHOTOLYZED STRUCTURE OF CO-BOUND HEME-HEME OXYGENASE COMPLEX
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Sugishima, M., Sakamoto, H., Noguchi, M., Fukuyama, K.
Deposit date:2003-09-16
Release date:2004-08-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
1VGI
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CRYSTAL STRUCTURE OF XENON BOUND RAT HEME-HEME OXYGENASE-1 COMPLEX
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, XENON, ...
Authors:Sugishima, M., Sakamoto, H., Noguchi, M., Fukuyama, K.
Deposit date:2004-04-26
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
2ZVU
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH FERROUS VERDOHEME
Descriptor:Heme oxygenase 1, 5-OXA-PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID
Authors:Sato, H., Sugishima, M., Fukuyama, K., Noguchi, M.
Deposit date:2008-11-21
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side
Biochem.J., 419, 2009
3WKT
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COMPLEX STRUCTURE OF AN OPEN FORM OF NADPH-CYTOCHROME P450 REDUCTASE AND HEME OXYGENASE-1
Descriptor:NADPH-cytochrome P450 reductase, Heme oxygenase 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Sugishima, M., Sato, H., Higashimoto, Y., Harada, J., Wada, K., Fukuyama, K., Noguchi, M.
Deposit date:2013-10-31
Release date:2014-01-29
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase.
Proc.Natl.Acad.Sci.USA, 111, 2014
4G7L
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CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME AND O2
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, OXYGEN MOLECULE, ...
Authors:Sugishima, M., Moffat, K., Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Biochemistry, 2012
4G7P
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RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME AND CO WITH 1 HR ILLUMINATION AT 100 K: LASER OFF
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Sugishima, M., Moffat, K., Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Biochemistry, 2012
4G7T
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RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME AND CO WITH 1 HR ILLUMINATION: LASER ON
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, ...
Authors:Sugishima, M., Moffat, K., Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Biochemistry, 2012
4G7U
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RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME AND CO WITH 16 HR ILLUMINATION: LASER OFF
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Sugishima, M., Moffat, K., Noguchi, M.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Biochemistry, 2012
4G8P
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RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME AND CO WITH 16 HR ILLUMINATION: LASER ON
Descriptor:Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, ...
Authors:Sugishima, M., Moffat, K., Noguchi, M.
Deposit date:2012-07-23
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Biochemistry, 2012
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