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4YBO
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STRUCTURE OF CITRATE SYNTHASE FROM THE THERMOACIDOPHILIC EURYARCHAEON THERMOLASMA ACIDOPHILUM
Descriptor:Citrate synthase, BICARBONATE ION
Authors:Murphy, J.R., Donini, S., Kappock, T.J.
Deposit date:2015-02-19
Release date:2015-09-02
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:An active site-tail interaction in the structure of hexahistidine-tagged Thermoplasma acidophilum citrate synthase.
Acta Crystallogr F Struct Biol Commun, 71, 2015
5DW4
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SUCCINYL-COA:ACETATE COA-TRANSFERASE (AARCH6) BOUND TO ACETATE
Descriptor:Succinyl-CoA:acetate CoA-transferase, IMIDAZOLE, ACETATE ION
Authors:Murphy, J.R., Kappock, T.J.
Deposit date:2015-09-22
Release date:2016-05-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.622 Å)
Cite:Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.
Front Chem, 4, 2016
5DDK
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SUCCINYL-COA:ACETATE COA-TRANSFERASE (AARCH6-N347A) IN COMPLEX WITH COA
Descriptor:Acetyl-CoA hydrolase, CHLORIDE ION, COENZYME A, ...
Authors:Kappock, T.J., Mullins, E.A., Murphy, J.R.
Deposit date:2015-08-25
Release date:2016-05-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.127 Å)
Cite:Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.
Front Chem, 4, 2016
5DW5
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SUCCINYL-COA:ACETATE COA-TRANSFERASE (AARCH6) BOUND TO THE COA ANALOGUE 3'-PHOSPHOADENOSINE 5'-(O-(N-PROPYLPANTOTHENAMIDE))PYROPHOSPHATE (MX)
Descriptor:Succinyl-CoA:acetate CoA-transferase, CHLORIDE ION, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-(propylamino)propyl]amino]butyl] hydrogen phosphate, ...
Authors:Kappock, T.J., Murphy, J.R.
Deposit date:2015-09-22
Release date:2016-05-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.656 Å)
Cite:Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.
Front Chem, 4, 2016
5DW6
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SUCCINYL-COA:ACETATE COA-TRANSFERASE (AARCH6) BOUND TO ACETATE AND THE COA ANALOGUE 3'-PHOSPHOADENOSINE 5'-(O-(N-PROPYL-R-PANTOTHENAMIDE))PYROPHOSPHATE (MX)
Descriptor:Succinyl-CoA:acetate CoA-transferase, ACETATE ION, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-(propylamino)propyl]amino]butyl] hydrogen phosphate, ...
Authors:Kappock, T.J., Murphy, J.R.
Deposit date:2015-09-22
Release date:2016-05-04
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.548 Å)
Cite:Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.
Front Chem, 4, 2016
1DDN
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DIPHTHERIA TOX REPRESSOR (C102D MUTANT)/TOX DNA OPERATOR COMPLEX
Descriptor:33 BASE DNA CONTAINING TOXIN OPERATOR, DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
Authors:White, A., Ding, X., Vanderspek, J.C., Murphy, J.R., Ringe, D.
Deposit date:1998-06-23
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
2TDX
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DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL
Descriptor:DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
Authors:White, A., Ding, X., Zheng, H., Schiering, N., Ringe, D., Murphy, J.R.
Deposit date:1998-06-22
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
1BYM
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SOLUTION STRUCTURES OF THE C-TERMINAL DOMAIN OF DIPHTHERIA TOXIN REPRESSOR
Descriptor:PROTEIN (DIPHTHERIA TOXIN REPRESSOR)
Authors:Wang, G., Wylie, G.P., Twigg, P.D., Caspar, D.L.D., Murphy, J.R., Logan, T.M.
Deposit date:1998-10-17
Release date:1998-10-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein.
Proc.Natl.Acad.Sci.USA, 96, 1999
1F5T
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DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE
Descriptor:43MER DNA CONTAINING DXTR CONSENSUS BINDING SEQUENCE, DIPHTHERIA TOXIN REPRESSOR, NICKEL (II) ION
Authors:Chen, S., White, A., Love, J., Murphy, J.R., Ringe, D.
Deposit date:2000-06-15
Release date:2000-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Methyl groups of thymine bases are important for nucleic acid recognition by DtxR.
Biochemistry, 39, 2000
1QVP
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C TERMINAL SH3-LIKE DOMAIN FROM DIPHTHERIA TOXIN REPRESSOR RESIDUES 144-226.
Descriptor:Diphtheria toxin repressor
Authors:Wylie, G.P., Rangachari, V., Bienkiewicz, E.A., Marin, V., Bhattacharya, N., Love, J.F., Murphy, J.R., Logan, T.M.
Deposit date:2003-08-28
Release date:2004-11-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Prolylpeptide binding by the prokaryotic SH3-like domain of the diphtheria toxin repressor: a regulatory switch.
Biochemistry, 44, 2005
1QW1
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF DTXR RESIDUES 110-226
Descriptor:Diphtheria toxin repressor
Authors:Wylie, G.P., Rangachari, V., Bienkiewicz, E.A., Love, J.F., Murphy, J.R., Logan, T.M.
Deposit date:2003-08-29
Release date:2005-03-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Prolylpeptide binding by the prokaryotic SH3-like domain of the diphtheria toxin repressor: a regulatory switch.
Biochemistry, 44, 2005
5E5H
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SUCCINYL-COA:ACETATE COA-TRANSFERASE (AARCH6) BOUND TO ACETATE AND DEGRADATION PRODUCTS FROM THE ACETYL-COA ANALOGUE DETHIAACETYL-COA
Descriptor:Succinyl-CoA:acetate CoA-transferase, CHLORIDE ION, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-(propylamino)propyl]amino]butyl] hydrogen phosphate, ...
Authors:Mullins, E.A., Kappock, T.J.
Deposit date:2015-10-08
Release date:2016-05-18
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.
Front Chem, 4, 2016
1DPR
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STRUCTURES OF THE APO-AND METAL ION ACTIVATED FORMS OF THE DIPHTHERIA TOX REPRESSOR FROM CORYNEBACTERIUM DIPHTHERIAE
Descriptor:DIPHTHERIA TOX REPRESSOR
Authors:Schiering, N., Tao, X., Murphy, J., Petsko, G.A., Ringe, D.
Deposit date:1995-02-06
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.
Proc.Natl.Acad.Sci.USA, 92, 1995
5TQ3
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, 4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ4
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR INHALED AND TOPICAL DELIVERY FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, 6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxamide
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ5
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR INHALED AND TOPICAL DELIVERY FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, 6-(2-ethyl-4-hydroxyphenyl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ6
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR INHALED AND TOPICAL DELIVERY FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ7
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR INHALED AND TOPICAL DELIVERY FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3R)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ8
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DESIGN AND SYNTHESIS OF A PAN-JAK KINASE INHIBITOR CLINICAL CANDIDATE (PF-06263276) SUITABLE FOR INHALED AND TOPICAL DELIVERY FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE LUNGS AND SKIN
Descriptor:Tyrosine-protein kinase JAK2, {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone
Authors:Chrencik, J., Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
2H09
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CRYSTAL STRUCTURE OF DIPHTHERIA TOXIN REPRESSOR LIKE PROTEIN FROM E. COLI
Descriptor:Transcriptional regulator mntR
Authors:Kumarevel, T.S., Tanaka, T., Shinkai, A., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-05-14
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the manganese transport regulatory protein from Escherichia coli.
Proteins, 2009