5TQ7

Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Summary for 5TQ7

• Entry DOI: 10.2210/pdb5tq7/pdb
• Related: 5TQ3 5TQ4 5TQ5 5TQ6 5TQ8
• Descriptor: Tyrosine-protein kinase JAK2, {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3R)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone (3 entities in total)
• Functional Keywords: kinase, inflammation, jak inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Endomembrane system ; Peripheral membrane protein : O60674
• Total number of polymer chains: 2
• Total formula weight: 72750.51

Authors

Chrencik, J.,Jones, P. (deposition date: 2016-10-23, release date: 2017-01-11, Last modification date: 2023-11-15)

• Primary citation: Jones, P.,Storer, R.I.,Sabnis, Y.A.,Wakenhut, F.M.,Whitlock, G.A.,England, K.S.,Mukaiyama, T.,Dehnhardt, C.M.,Coe, J.W.,Kortum, S.W.,Chrencik, J.E.,Brown, D.G.,Jones, R.M.,Murphy, J.R.,Yeoh, T.,Morgan, P.,Kilty, I.; Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.; J. Med. Chem., 60:767-786, 2017; PubMed: 27983835; DOI: 10.1021/acs.jmedchem.6b01634

Experimental method

X-RAY DIFFRACTION (2.1 Å)