Author results

4LZD
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HUMAN DNA POLYMERASE MU- APOENZYME
Descriptor:DNA-directed DNA/RNA polymerase mu, SODIUM ION, IMIDAZOLE, ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2013-07-31
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Sustained active site rigidity during synthesis by human DNA polymerase mu.
Nat.Struct.Mol.Biol., 21, 2014
4LZG
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BINARY COMPLEX OF HUMAN DNA POLYMERASE MU WITH DNA
Descriptor:DNA-directed DNA/RNA polymerase mu, template strand, upstream primer strand, ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2013-07-31
Release date:2014-02-05
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Sustained active site rigidity during synthesis by human DNA polymerase mu.
Nat.Struct.Mol.Biol., 21, 2014
4M04
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HUMAN DNA POLYMERASE MU TERNARY COMPLEX
Descriptor:DNA-directed DNA/RNA polymerase mu, template strand, upstream primer strand, ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2013-08-01
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Sustained active site rigidity during synthesis by human DNA polymerase mu.
Nat.Struct.Mol.Biol., 21, 2014
4M0A
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HUMAN DNA POLYMERASE MU POST-CATALYTIC COMPLEX
Descriptor:DNA-directed DNA/RNA polymerase mu, template strand, upstream primer strand, ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2013-08-01
Release date:2014-02-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Sustained active site rigidity during synthesis by human DNA polymerase mu.
Nat.Struct.Mol.Biol., 21, 2014
1T8T
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CRYSTAL STRUCTURE OF HUMAN 3-O-SULFOTRANSFERASE-3 WITH BOUND PAP
Descriptor:heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, ADENOSINE-3'-5'-DIPHOSPHATE, CITRIC ACID
Authors:Moon, A.F., Edavettal, S.C., Krahn, J.M., Munoz, E.M., Negishi, M., Linhardt, R.J., Liu, J., Pedersen, L.C.
Deposit date:2004-05-13
Release date:2004-08-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1
J.Biol.Chem., 279, 2004
1T8U
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CRYSTAL STRUCTURE OF HUMAN 3-O-SULFOTRANSFERASE-3 WITH BOUND PAP AND TETRASACCHARIDE SUBSTRATE
Descriptor:heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, SULFATE ION, SODIUM ION, ...
Authors:Moon, A.F., Edavettal, S.C., Krahn, J.M., Munoz, E.M., Negishi, M., Linhardt, R.J., Liu, J., Pedersen, L.C.
Deposit date:2004-05-13
Release date:2004-08-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1
J.Biol.Chem., 279, 2004
2IHM
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POLYMERASE MU IN TERNARY COMPLEX WITH GAPPED 11MER DNA DUPLEX AND BOUND INCOMING NUCLEOTIDE
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Moon, A.F., Pedersen, L.C., Kunkel, T.A.
Deposit date:2006-09-26
Release date:2006-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into the substrate specificity of DNA Polymerase mu.
Nat.Struct.Mol.Biol., 14, 2007
3OWV
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STRUCTURAL INSIGHTS INTO CATALYTIC AND SUBSTRATE BINDING MECHANISMS OF THE STRATEGIC ENDA NUCLEASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:DNA-entry nuclease, MAGNESIUM ION, CHLORIDE ION
Authors:Moon, A.F., Midon, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.
Deposit date:2010-09-20
Release date:2010-12-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae.
Nucleic Acids Res., 39, 2011
3UAN
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CRYSTAL STRUCTURE OF 3-O-SULFOTRANSFERASE (3-OST-1) WITH BOUND PAP AND HEPTASACCHARIDE SUBSTRATE
Descriptor:Heparan sulfate glucosamine 3-O-sulfotransferase 1, ADENOSINE-3'-5'-DIPHOSPHATE, 2-(acetylamino)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose, ...
Authors:Moon, A.F., Xu, Y., Woody, S.M., Krahn, J.M., Linhardt, R.J., Liu, J., Pedersen, L.C.
Deposit date:2011-10-21
Release date:2012-04-04
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.844 Å)
Cite:Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin.
Proc.Natl.Acad.Sci.USA, 109, 2012
4QH0
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CRYSTAL STRUCTURE OF NUCA FROM STREPTOCOCCUS AGALACTIAE WITH MAGNESIUM ION BOUND
Descriptor:DNA-entry nuclease (Competence-specific nuclease), MAGNESIUM ION, SULFATE ION, ...
Authors:Moon, A.F., Gaudu, P., Pedersen, L.C.
Deposit date:2014-05-26
Release date:2014-11-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the virulence factor nuclease A from Streptococcus agalactiae.
Acta Crystallogr.,Sect.D, 70, 2014
4YCX
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BINARY COMPLEX OF HUMAN DNA POLYMERASE MU WITH 2-NT GAPPED DNA SUBSTRATE
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Gosavi, R.A., Kunkel, T.A., Pedersen, L.C., Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YD1
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE MU WITH 2-NT GAPPED DNA SUBSTRATE AND AN INCOMING NONHYDROLYZABLE DUMPNPP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Gosavi, R.A., Kunkel, T.A., Pedersen, L.C., Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YD2
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NICKED COMPLEX OF HUMAN DNA POLYMERASE MU WITH 2-NT GAPPED DNA SUBSTRATE
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ...
Authors:Moon, A.F., Gosavi, R.A., Kunkel, T.A., Pedersen, L.C., Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.471 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FGU
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STRUCTURE OF SDA1 NUCLEASE APOPROTEIN AS AN EGFP FIXED-ARM FUSION
Descriptor:Green fluorescent protein,Extracellular streptodornase D, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Moon, A.F., Krahn, J.M., Xun, L., Cuneo, M.J., Pedersen, L.C.
Deposit date:2015-12-21
Release date:2016-03-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes.
Nucleic Acids Res., 44, 2016
5FGW
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STRUCTURE OF SDA1 NUCLEASE WITH BOUND ZINC ION
Descriptor:Extracellular streptodornase D, ZINC ION, CHLORIDE ION, ...
Authors:Moon, A.F., Krahn, J.M., Xun, L., Cuneo, M.J., Pedersen, L.C.
Deposit date:2015-12-21
Release date:2016-03-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes.
Nucleic Acids Res., 44, 2016
5TWP
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PRE-CATALYTIC TERNARY COMPLEX OF HUMAN POLYMERASE MU WITH INCOMING NONHYDROLYZABLE UMPNPP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2016-11-14
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5TWQ
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POST-CATALYTIC NICKED COMPLEX OF HUMAN POLYMERASE MU WITH NEWLY INCORPORATED UTP
Descriptor:human DNA Polymerase Mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA/RNA (5'-D(*CP*GP*TP*A)-R(P*U)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2016-11-14
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5TWR
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PRE-CATALYTIC TERNARY COMPLEX OF HUMAN POLYMERASE MU (H329A) MUTANT WITH INCOMING NONHYDROLYZABLE UMPNPP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2016-11-14
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5TWS
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POST-CATALYTIC COMPLEX OF HUMAN POLYMERASE MU (H329A) WITH NEWLY INCORPORATED UTP
Descriptor:human DNA Polymerase Mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA/RNA (5'-D(*CP*GP*TP*A)-R(P*U)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2016-11-14
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZ7
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PRE-CATALYTIC TERNARY COMPLEX OF HUMAN POLYMERASE MU (G433A) MUTANT WITH INCOMING NONHYDROLYZABLE UMPNPP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZ8
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POST-CATALYTIC COMPLEX OF HUMAN POLYMERASE MU (G433A) MUTANT WITH INCOMING UTP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA/RNA (5'-D(*CP*GP*TP*A)-R(P*U)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZ9
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POST-CATALYTIC COMPLEX OF HUMAN POLYMERASE MU (G433A) MUTANT WITH INCOMING DTTP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZA
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PRE-CATALYTIC TERNARY COMPLEX OF HUMAN POLYMERASE MU (G433S) MUTANT WITH INCOMING NONHYDROLYZABLE UMPNPP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZB
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POST-CATALYTIC COMPLEX OF HUMAN POLYMERASE MU (G433S) MUTANT WITH INCOMING UTP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA/RNA (5'-D(*CP*GP*TP*A)-R(P*U)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
5VZC
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POST-CATALYTIC COMPLEX OF HUMAN POLYMERASE MU (G433S) MUTANT WITH INCOMING DTTP
Descriptor:DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ...
Authors:Moon, A.F., Pryor, J.M., Ramsden, D.A., Kunkel, T.A., Bebenek, K., Pedersen, L.C.
Deposit date:2017-05-27
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.552 Å)
Cite:Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.
Nucleic Acids Res., 45, 2017
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