Author results

1HYV
  • Download 1hyv
  • View 1hyv
Molmil generated image of 1hyv
HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
1HYZ
  • Download 1hyz
  • View 1hyz
Molmil generated image of 1hyz
HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM.
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
1S17
  • Download 1s17
  • View 1s17
Molmil generated image of 1s17
IDENTIFICATION OF NOVEL POTENT BICYCLIC PEPTIDE DEFORMYLASE INHIBITORS
Descriptor:Peptide deformylase, NICKEL (II) ION, 2-(3,4-DIHYDRO-3-OXO-2H-BENZO[B][1,4]THIAZIN-2-YL)-N-HYDROXYACETAMIDE, ...
Authors:Molteni, V., He, X., Nabakka, J., Yang, K., Kreusch, A., Gordon, P., Bursulaya, B., Ryder, N.S., Goldberg, R., He, Y.
Deposit date:2004-01-05
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of novel potent bicyclic peptide deformylase inhibitors
Bioorg.Med.Chem.Lett., 14, 2004
4YMJ
  • Download 4ymj
  • View 4ymj
Molmil generated image of 4ymj
(R)-2-PHENYLPYRROLIDINE SUBSTITUTE IMIDAZOPYRIDAZINES: A NEW CLASS OF POTENT AND SELECTIVE PAN-TRK INHIBITORS
Descriptor:NT-3 growth factor receptor, 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile, GLYCEROL, ...
Authors:Kreusch, A., Rucker, P., Molteni, V., Loren, J.
Deposit date:2015-03-06
Release date:2015-06-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4YNE
  • Download 4yne
  • View 4yne
Molmil generated image of 4yne
(R)-2-PHENYLPYRROLIDINE SUBSTITUTE IMIDAZOPYRIDAZINES: A NEW CLASS OF POTENT AND SELECTIVE PAN-TRK INHIBITORS
Descriptor:High affinity nerve growth factor receptor, 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine, SULFATE ION, ...
Authors:Kreusch, A., Rucker, P., Molteni, V., Loren, J.
Deposit date:2015-03-09
Release date:2015-06-03
Method:X-RAY DIFFRACTION (2.0229 Å)
Cite:(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4YPS
  • Download 4yps
  • View 4yps
Molmil generated image of 4yps
(R)-2-PHENYLPYRROLIDINE SUBSTITUTE IMIDAZOPYRIDAZINES: A NEW CLASS OF POTENT AND SELECTIVE PAN-TRK INHIBITORS
Descriptor:High affinity nerve growth factor receptor, 4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile, SULFATE ION
Authors:Kreusch, A., Rucker, P., Molteni, V., Loren, J.
Deposit date:2015-03-13
Release date:2015-06-03
Method:X-RAY DIFFRACTION (2.1012 Å)
Cite:(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Acs Med.Chem.Lett., 6, 2015
3V5Q
  • Download 3v5q
  • View 3v5q
Molmil generated image of 3v5q
DISCOVERY OF A SELECTIVE TRK INHIBITOR WITH EFFICACY IN RODENT CANCER TUMOR MODELS
Descriptor:NT-3 growth factor receptor, CHLORIDE ION, 1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea
Authors:Kreusch, A.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2001 Å)
Cite:Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
ACS Med Chem Lett, 3, 2012