7RUN
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.
Summary for 7RUN
Entry DOI | 10.2210/pdb7run/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase receptor Ret, CHLORIDE ION, 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one (3 entities in total) |
Functional Keywords | tyrosine-protein kinase, inhibitor, cell adhesion, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 78276.55 |
Authors | Lee, C.C.,Spraggon, G. (deposition date: 2021-08-17, release date: 2022-01-19, Last modification date: 2023-11-15) |
Primary citation | Mathison, C.J.N.,Yang, Y.,Nelson, J.,Huang, Z.,Jiang, J.,Chianelli, D.,Rucker, P.V.,Roland, J.,Xie, Y.F.,Epple, R.,Bursulaya, B.,Lee, C.,Gao, M.Y.,Shaffer, J.,Briones, S.,Sarkisova, Y.,Galkin, A.,Li, L.,Li, N.,Li, C.,Hua, S.,Kasibhatla, S.,Kinyamu-Akunda, J.,Kikkawa, R.,Molteni, V.,Tellew, J.E. Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- d ]pyrimidine RET Inhibitors. Acs Med.Chem.Lett., 12:1912-1919, 2021 Cited by PubMed: 34917254DOI: 10.1021/acsmedchemlett.1c00450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.51 Å) |
Structure validation
Download full validation report