7RUN
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 334 | 38662.9 | 2 | UniProt (P07949) Pfam (PF07714) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
3 | A, B | 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one | non-polymer | 439.9 | 2 | Chemie (7QU) |
Sequence modifications
A, B: 705 - 1013 (UniProt: P07949)
PDB | External Database | Details |
---|---|---|
Met 680 | - | initiating methionine |
Ser 681 | - | expression tag |
Tyr 682 | - | expression tag |
Tyr 683 | - | expression tag |
His 684 | - | expression tag |
His 685 | - | expression tag |
His 686 | - | expression tag |
His 687 | - | expression tag |
His 688 | - | expression tag |
His 689 | - | expression tag |
Asp 690 | - | expression tag |
Tyr 691 | - | expression tag |
Asp 692 | - | expression tag |
Ile 693 | - | expression tag |
Pro 694 | - | expression tag |
Thr 695 | - | expression tag |
Thr 696 | - | expression tag |
Glu 697 | - | expression tag |
Asn 698 | - | expression tag |
Leu 699 | - | expression tag |
Tyr 700 | - | expression tag |
Phe 701 | - | expression tag |
Gln 702 | - | expression tag |
Gly 703 | - | expression tag |
Ala 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 77325.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 950.8 | |
All* | Total formula weight | 78276.6 |