7RUN

Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Proto-oncogene tyrosine-protein kinase receptor Ret	polymer	334	38662.9	2	UniProt (P07949) Pfam (PF07714) In PDB	Homo sapiens (Human)	Cadherin family member 12,Proto-oncogene c-Ret
2	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	A, B	1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one	non-polymer		439.9	2	Chemie (7QU)

Sequence modifications

A, B: 705 - 1013 (UniProt: P07949)

PDB	External Database	Details
Met 680	-	initiating methionine
Ser 681	-	expression tag
Tyr 682	-	expression tag
Tyr 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
His 689	-	expression tag
Asp 690	-	expression tag
Tyr 691	-	expression tag
Asp 692	-	expression tag
Ile 693	-	expression tag
Pro 694	-	expression tag
Thr 695	-	expression tag
Thr 696	-	expression tag
Glu 697	-	expression tag
Asn 698	-	expression tag
Leu 699	-	expression tag
Tyr 700	-	expression tag
Phe 701	-	expression tag
Gln 702	-	expression tag
Gly 703	-	expression tag
Ala 704	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77325.8
Non-Polymers*	Number of molecules	4
	Total formula weight	950.8
All*	Total formula weight	78276.6

*Water molecules are not included.