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2DY3
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BU of 2dy3 by Molmil
Crystal Structure of alanine racemase from Corynebacterium glutamicum
Descriptor: Alanine racemase, PYRIDOXAL-5'-PHOSPHATE
Authors:Miyaguchi, I, Sasaki, C, Kato, R, Oikawa, T, Sugio, S.
Deposit date:2006-09-05
Release date:2007-09-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Alanine Racemase from Corynebacterium glutamicum at 2.1 A resolution
To be Published
8HB0
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BU of 8hb0 by Molmil
Structure of human SGLT2-MAP17 complex with TA1887
Descriptor: (2R,3R,4S,5S,6R)-2-[3-[(4-cyclopropylphenyl)methyl]-4-fluoranyl-indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ...
Authors:Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O.
Deposit date:2022-10-27
Release date:2023-11-01
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
8HG7
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BU of 8hg7 by Molmil
Structure of human SGLT2-MAP17 complex with Sotagliflozin
Descriptor: (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ...
Authors:Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O.
Deposit date:2022-11-14
Release date:2023-11-15
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
8HEZ
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BU of 8hez by Molmil
Structure of human SGLT2-MAP17 complex with Dapagliflozin
Descriptor: (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ...
Authors:Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O.
Deposit date:2022-11-09
Release date:2023-11-15
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
8HDH
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BU of 8hdh by Molmil
Structure of human SGLT2-MAP17 complex with Canagliflozin
Descriptor: (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ...
Authors:Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O.
Deposit date:2022-11-04
Release date:2023-11-08
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
8HIN
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BU of 8hin by Molmil
Structure of human SGLT2-MAP17 complex with Phlorizin
Descriptor: 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ...
Authors:Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O.
Deposit date:2022-11-21
Release date:2023-11-22
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
3W2T
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BU of 3w2t by Molmil
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne, ...
Authors:Kishida, H, Nabeno, M, Miyaguchi, I, Tanaka, Y, Katou, R, Akahoshi, F.
Deposit date:2012-12-04
Release date:2013-05-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
Biochem.Biophys.Res.Commun., 434, 2013
3VJL
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BU of 3vjl by Molmil
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
Authors:Akahoshi, F, Kishida, H, Miyaguchi, I, Yoshida, T, Ishii, S.
Deposit date:2011-10-24
Release date:2012-10-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem., 20, 2012
3VJK
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BU of 3vjk by Molmil
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with MP-513
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
Authors:Akahoshi, F, Kishida, H, Miyaguchi, I, Yoshida, T, Ishii, S.
Deposit date:2011-10-24
Release date:2012-10-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem., 20, 2012
3VJM
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BU of 3vjm by Molmil
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1
Descriptor: 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Akahoshi, F, Kishida, H, Miyaguchi, I, Yoshida, T, Ishii, S.
Deposit date:2011-10-24
Release date:2012-08-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
Bioorg.Med.Chem., 20, 2012

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PDB entries from 2024-09-18

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