3VJM

Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1

Summary for 3VJM

Entry DOI	10.2210/pdb3vjm/pdb
Related	3VJK 3VJL
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone, ... (5 entities in total)
Functional Keywords	alpha/beta, beta-propeller, aminopeptidase, serine protease, signal-anchor, transmembrane, diabetes, glycoprotein, cell membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	176361.59
Authors	Akahoshi, F.,Kishida, H.,Miyaguchi, I.,Yoshida, T.,Ishii, S. (deposition date: 2011-10-24, release date: 2012-08-15, Last modification date: 2023-11-08)
Primary citation	Yoshida, T.,Akahoshi, F.,Sakashita, H.,Sonda, S.,Takeuchi, M.,Tanaka, Y.,Nabeno, M.,Kishida, H.,Miyaguchi, I.,Hayashi, Y. Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group Bioorg.Med.Chem., 20:5033-5041, 2012 Cited by PubMed: 22824762 DOI: 10.1016/j.bmc.2012.06.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation