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2DY3
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CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM CORYNEBACTERIUM GLUTAMICUM
Descriptor:Alanine racemase, PYRIDOXAL-5'-PHOSPHATE
Authors:Miyaguchi, I., Sasaki, C., Kato, R., Oikawa, T., Sugio, S.
Deposit date:2006-09-05
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Alanine Racemase from Corynebacterium glutamicum at 2.1 A resolution
To be Published
3VJK
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CRYSTAL STRUCTURE OF HUMAN DEPIPTIDYL PEPTIDASE IV (DPP-4) IN COMPLEX WITH MP-513
Descriptor:Dipeptidyl peptidase 4, {(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone, N-ACETYL-D-GLUCOSAMINE
Authors:Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.
Deposit date:2011-10-24
Release date:2012-10-24
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem., 20, 2012
3VJL
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CRYSTAL STRUCTURE OF HUMAN DEPIPTIDYL PEPTIDASE IV (DPP-4) IN COMPLEX WITH A PROLYLTHIAZOLIDINE INHIBITOR #2
Descriptor:Dipeptidyl peptidase 4, [(2S,4S)-4-{4-[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]piperidin-1-yl}pyrrolidin-2-yl](1,3-thiazolidin-3-yl)methanone, N-ACETYL-D-GLUCOSAMINE
Authors:Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.
Deposit date:2011-10-24
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem., 20, 2012
3VJM
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CRYSTAL STRUCTURE OF HUMAN DEPIPTIDYL PEPTIDASE IV (DPP-4) IN COMPLEX WITH A PROLYLTHIAZOLIDINE INHIBITOR #1
Descriptor:Dipeptidyl peptidase 4, 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone, N-ACETYL-D-GLUCOSAMINE
Authors:Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.
Deposit date:2011-10-24
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
Bioorg.Med.Chem., 20, 2012
3W2T
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CRYSTAL STRUCTURE OF HUMAN DEPIPTIDYL PEPTIDASE IV (DPP-4) IN COMPLEX WITH VILDAGLIPTIN
Descriptor:Dipeptidyl peptidase 4, 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-one, GLYCEROL, ...
Authors:Kishida, H., Nabeno, M., Miyaguchi, I., Tanaka, Y., Katou, R., Akahoshi, F.
Deposit date:2012-12-04
Release date:2013-05-15
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
Biochem.Biophys.Res.Commun., 434, 2013