Author results

1QAE
  • Download 1qae
  • View 1qae
Molmil generated image of 1qae
THE ACTIVE SITE OF SERRATIA ENDONUCLEASE CONTAINS A CONSERVED MAGNESIUM-WATER CLUSTER
分子名称:PROTEIN (EXTRACELLULAR ENDONUCLEASE), MAGNESIUM ION
著者Miller, M.D., Krause, K.L.
登録日1999-03-03
公開日1999-05-18
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The active site of Serratia endonuclease contains a conserved magnesium-water cluster.
J.Mol.Biol., 288, 1999
1SMN
  • Download 1smn
  • View 1smn
Molmil generated image of 1smn
IDENTIFICATION OF THE SERRATIA ENDONUCLEASE DIMER: STRUCTURAL BASIS AND IMPLICATIONS FOR CATALYSIS
分子名称:EXTRACELLULAR ENDONUCLEASE
著者Miller, M.D., Krause, K.L.
登録日1995-01-25
公開日1996-01-29
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Identification of the Serratia endonuclease dimer: structural basis and implications for catalysis.
Protein Sci., 5, 1996
1KQ3
  • Download 1kq3
  • View 1kq3
Molmil generated image of 1kq3
CRYSTAL STRUCTURE OF A GLYCEROL DEHYDROGENASE (TM0423) FROM THERMOTOGA MARITIMA AT 1.5 A RESOLUTION
分子名称:glycerol dehydrogenase, ZINC ION, CHLORIDE ION, ...
著者Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
登録日2002-01-03
公開日2002-02-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
1KQ4
  • Download 1kq4
  • View 1kq4
Molmil generated image of 1kq4
CRYSTAL STRUCTURE OF A THY1-COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA AT 2.25 A RESOLUTION
分子名称:HYPOTHETICAL PROTEIN TM0449, FLAVIN-ADENINE DINUCLEOTIDE
著者Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
登録日2002-01-03
公開日2002-02-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
5D6Y
  • Download 5d6y
  • View 5d6y
Molmil generated image of 5d6y
CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4A COMPLEXED WITH HISTONE H3K23ME3
分子名称:Lysine-specific demethylase 4A, peptide H3K23me3 (19-28)
著者Wang, F., Su, Z., Miller, M.D., Denu, J.M., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-08-13
公開日2016-02-10
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.287 Å)
主引用文献Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
1MZI
  • Download 1mzi
  • View 1mzi
Molmil generated image of 1mzi
SOLUTION ENSEMBLE STRUCTURES OF HIV-1 GP41 2F5 MAB EPITOPE
分子名称:2F5 epitope of HIV-1 gp41 fusion protein
著者Barbato, G., Bianchi, E., Ingallinella, P., Hurni, W.H., Miller, M.D., Ciliberto, G., Cortese, R., Bazzo, R., Shiver, J.W., Pessi, A.
登録日2002-10-08
公開日2003-09-02
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion.
J.Mol.Biol., 330, 2003
2CMR
  • Download 2cmr
  • View 2cmr
Molmil generated image of 2cmr
CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER-CORE MIMETIC 5-HELIX
分子名称:TRANSMEMBRANE GLYCOPROTEIN, D5, GLYCEROL
著者Luftig, M.A., Mattu, M., Di Giovine, P., Geleziunas, R., Hrin, R., Barbato, G., Bianchi, E., Miller, M.D., Pessi, A., Carfi, A.
登録日2006-05-11
公開日2006-10-16
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for HIV-1 Neutralization by a Gp41 Fusion Intermediate-Directed Antibody
Nat.Struct.Mol.Biol., 13, 2006
4PIW
  • Download 4piw
  • View 4piw
Molmil generated image of 4piw
CRYSTAL STRUCTURE OF SUGAR AMINOTRANSFERASE WECE FROM ESCHERICHIA COLI K-12
分子名称:TDP-4-keto-6-deoxy-D-glucose transaminase family protein
著者Wang, F., Xu, W., Helmich, K.E., Singh, S., Yennamalli, R.M., Miller, M.D., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-05-09
公開日2014-07-16
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of sugar aminotransferase WecE from Escherichia coli K-12
To Be Published
4UCO
  • Download 4uco
  • View 4uco
Molmil generated image of 4uco
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4UCR
  • Download 4ucr
  • View 4ucr
Molmil generated image of 4ucr
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxy-2-methylquinoline-6-carboxamide
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4UCS
  • Download 4ucs
  • View 4ucs
Molmil generated image of 4ucs
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4UCT
  • Download 4uct
  • View 4uct
Molmil generated image of 4uct
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-amino-6-methyl-5-(propan-2-yloxy)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4UCU
  • Download 4ucu
  • View 4ucu
Molmil generated image of 4ucu
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 8-hydroxyquinoline-2-carboxylic acid, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4UCV
  • Download 4ucv
  • View 4ucv
Molmil generated image of 4ucv
FRAGMENT BOUND TO H.INFLUENZA NAD DEPENDENT DNA LIGASE
分子名称:DNA LIGASE, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-methoxy-2,3-dimethylquinoxalin-5-ol
著者Hale, M., Brassington, C., Carcanague, D., Embrey, K., Eyermann, C.J., Giacobbe, R.A., Gingipali, L., Gowravaram, M., Harang, J., Howard, T., Ioannidis, G., Jahic, H., Kutschke, A., Laganas, V.A., Loch, J., Miller, M.D., Murphy-Benenato, K.E., Oguto, H., Otterbein, L., Patel, S.J., Shapiro, A.B., Boriack-Sjodin, P.A.
登録日2014-12-04
公開日2015-10-14
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
4WF1
  • Download 4wf1
  • View 4wf1
Molmil generated image of 4wf1
CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO NEGAMYCIN.
分子名称:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
著者Olivier, N.B., Altman, R.B., Noeske, J., Basarab, G.S., Code, E., Ferguson, A.D., Gao, N., Huang, J., Juette, M.F., Livchak, S., Miller, M.D., Prince, D.B., Cate, J.H.D., Buurman, E.T., Blanchard, S.C.
登録日2014-09-11
公開日2014-11-05
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Z5P
  • Download 4z5p
  • View 4z5p
Molmil generated image of 4z5p
CRYSTAL STRUCTURE OF THE LNMA CYTOCHROME P450 HYDROXYLASE FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY OF STREPTOMYCES ATROOLIVACEUS S-140 AT 1.9 A RESOLUTION
分子名称:Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, TRIETHYLENE GLYCOL
著者Ma, M., Lohman, J., Rudolf, J., Miller, M.D., Cao, H., Osipiuk, J., Babnigg, G., Phillips Jr., G.N., Joachimiak, A., Shen, B., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-04-02
公開日2015-07-29
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the LnmA cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140
To be Published
4Z5Q
  • Download 4z5q
  • View 4z5q
Molmil generated image of 4z5q
CRYSTAL STRUCTURE OF THE LNMZ CYTOCHROME P450 HYDROXYLASE FROM THE LEINAMYCIN BIOSYNTHETIC PATHWAY OF STREPTOMYCES ATROOLIVACEUS S-140 AT 1.8 A RESOLUTION
分子名称:Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, MAGNESIUM ION, ...
著者Ma, M., Lohman, J., Rudolf, J., Miller, M.D., Cao, H., Osipiuk, J., Joachimiak, A., Phillips Jr., G.N., Shen, B., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-04-02
公開日2015-08-12
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Crystal structure of the LnmZ cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140
To be Published
4ZAH
  • Download 4zah
  • View 4zah
Molmil generated image of 4zah
CRYSTAL STRUCTURE OF SUGAR AMINOTRANSFERASE WECE WITH EXTERNAL ALDIMINE VII FROM ESCHERICHIA COLI K-12
分子名称:dTDP-4-amino-4,6-dideoxygalactose transaminase, [[(2R,3S,5R)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3R,4S,5R,6R)-6-methyl-5-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate
著者Wang, F., Singh, S., Cao, H., Xu, W., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-04-13
公開日2015-04-29
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.
Acs Chem.Biol., 10, 2015
4ZAS
  • Download 4zas
  • View 4zas
Molmil generated image of 4zas
CRYSTAL STRUCTURE OF SUGAR AMINOTRANSFERASE CALS13 FROM MICROMONOSPORA ECHINOSPORA
分子名称:CalS13, SULFATE ION, dTDP-4-keto-6-deoxyglucose, ...
著者Wang, F., Singh, S., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-04-13
公開日2015-04-29
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structure characterization of sugar aminotransferases CalS13 and WecE provides the basis for a unifying structural model for stereochemical outcome.
To Be Published
5MG0
  • Download 5mg0
  • View 5mg0
Molmil generated image of 5mg0
STRUCTURE OF PAS-GAF FRAGMENT OF DEINOCOCCUS PHYTOCHROME BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY
分子名称:Bacteriophytochrome, 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium-2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, NICKEL (II) ION, ...
著者Burgie, E.S., Fuller, F.D., Gul, S., Miller, M.D., Young, I.D., Brewster, A.S., Clinger, J., Aller, P., Braeuer, P., Hutchison, C., Alonso-Mori, R., Kern, J., Yachandra, V.K., Yano, J., Sauter, N.K., Phillips Jr., G.N., Vierstra, R.D., Orville, A.M.
登録日2016-11-20
公開日2017-02-22
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.
Nat. Methods, 14, 2017
6AX6
  • Download 6ax6
  • View 6ax6
Molmil generated image of 6ax6
THE CRYSTAL STRUCTURE OF A LYSYL HYDROXYLASE FROM ACANTHAMOEBA POLYPHAGA MIMIVIRUS
分子名称:Procollagen lysyl hydroxylase and glycosyltransferase, IODIDE ION, FE (II) ION
著者Guo, H., Tsai, C., Miller, M.D., Alvarado, S., Tainer, J.A., Phillips Jr., G.N., Kurie, J.M.
登録日2017-09-06
公開日2018-02-21
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.241 Å)
主引用文献Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.
Nat Commun, 9, 2018
6AX7
  • Download 6ax7
  • View 6ax7
Molmil generated image of 6ax7
THE CRYSTAL STRUCTURE OF A LYSYL HYDROXYLASE FROM ACANTHAMOEBA POLYPHAGA MIMIVIRUS
分子名称:Procollagen lysyl hydroxylase and glycosyltransferase, FE (II) ION
著者Guo, H., Tsai, C., Miller, M.D., Alvarado, S., Tainer, J.A., Phillips Jr., G.N., Kurie, J.M.
登録日2017-09-06
公開日2018-02-21
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.
Nat Commun, 9, 2018
6BMG
  • Download 6bmg
  • View 6bmg
Molmil generated image of 6bmg
STRUCTURE OF RECOMBINANT DWARF SPERM WHALE MYOGLOBIN (OXY)
分子名称:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, OXYGEN MOLECULE, ...
著者Samuel, P.P., Miller, M.D., Xu, W., Alvarado, S., Phillips Jr., G.N., Olson, J.S.
登録日2017-11-14
公開日2017-11-29
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structure of Recombinant Dwarf Sperm Whale Myoglobin (Oxy)
To Be Published
6DA6
  • Download 6da6
  • View 6da6
Molmil generated image of 6da6
CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES, APO FORM AT 2.6 A RESOLUTION (P212121)
分子名称:UbiD-like decarboxylase, MAGNESIUM ION, GLYCEROL, ...
著者Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-05-01
公開日2018-10-03
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
6DA7
  • Download 6da7
  • View 6da7
Molmil generated image of 6da7
CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES WITH APO FORM AT 1.83 A RESOLUTION (I222)
分子名称:UbiD-like decarboxylase, SODIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2018-05-01
公開日2018-10-03
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018