Author results

1Q50
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PHOSPHOGLUCOSE ISOMERASE FROM LEISHMANIA MEXICANA.
Descriptor:Glucose-6-phosphate isomerase
Authors:Cordeiro, A.T., Michels, P.A.M., Delboni, L.F., Thiemann, O.H.
Deposit date:2003-08-05
Release date:2004-06-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of glucose-6-phosphate isomerase from leishmania mexicana reveals novel active site features
EUR.J.BIOCHEM., 271, 2004
3SRK
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A NEW CLASS OF SUICIDE INHIBITOR BLOCKS NUCLEOTIDE BINDING TO PYRUVATE KINASE
Descriptor:Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ...
Authors:Morgan, H.P., Walsh, M., Blackburn, E.A., Wear, M.A., Boxer, M., Shen, M., McNae, I.W., Michels, P.A.M., Auld, D.S., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published
3ZBG
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CRYSTAL STRUCTURE OF WILD-TYPE SCP2 THIOLASE FROM LEISHMANIA MEXICANA AT 1.85 A
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-09
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBK
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA: THE C123A MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE, CHLORIDE ION, ...
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBL
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA: THE C123S MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBN
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA. COMPLEX OF THE C123A MUTANT WITH COENZYME A.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, COENZYME A
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-11
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
4BI9
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CRYSTAL STRUCTURE OF WILD-TYPE SCP2 THIOLASE FROM TRYPANOSOMA BRUCEI.
Descriptor:3-KETOACYL-COA THIOLASE, PUTATIVE
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2013-04-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
4BIA
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM TRYPANOSOMA BRUCEI: THE C337A MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE, PUTATIVE
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2013-04-10
Release date:2013-08-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
5AZI
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CRYSTAL STRUCTURE OF GLYCEROL KINASE FROM TRYPANOSOMA BRUCEI GAMBIENSE COMPLEXED WITH 4NP
Descriptor:Glycerol kinase, 4-NITROPHENYL PHOSPHATE, GLYCEROL
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tokuoka, S.M., Tokumasu, F., Sakamoto, K., Michels, P.A.M., Harada, S., Kita, K.
Deposit date:2015-10-08
Release date:2016-10-19
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Glycerol kinase of African human trypanosomes possesses an intrinsic phosphatase activity that can be exploited to accelerate anti-trypanosomal drug design
To Be Published
5AZJ
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CRYSTAL STRUCTURE OF GLYCEROL KINASE FROM TRYPANOSOMA BRUCEI GAMBIENSE COMPLEXED WITH 4NP (WITH DISULFIDE BRIDGE)
Descriptor:Glycerol kinase, 4-NITROPHENYL PHOSPHATE, GLYCEROL
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tokuoka, S.M., Tokumasu, F., Sakamoto, K., Michels, P.A.M., Harada, S., Kita, K.
Deposit date:2015-10-08
Release date:2016-10-19
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Glycerol kinase of African human trypanosomes possesses an intrinsic phosphatase activity that can be exploited to accelerate anti-trypanosomal drug design
To Be Published
5GN5
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CRYSTAL STRUCTURE OF GLYCEROL KINASE FROM TRYPANOSOMA BRUCEI GAMBIENSE COMPLEXED WITH CUMARIN DERIVATIVE-17
Descriptor:Glycerol kinase, 4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-7,8-bis(oxidanyl)chromen-2-one, GLYCEROL
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, T., May, B., Sato, T., Kido, Y., Takeshi, N., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y., Moore, A.L., Harada, S., Kita, K.
Deposit date:2016-07-19
Release date:2017-07-26
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery of trypanocidal coumarins with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase
To Be Published
5GN6
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CRYSTAL STRUCTURE OF GLYCEROL KINASE FROM TRYPANOSOMA BRUCEI GAMBIENSE COMPLEXED WITH CUMARIN DERIVATIVE-17B
Descriptor:Glycerol kinase, 4-butyl-7,8-bis(oxidanyl)chromen-2-one, GLYCEROL
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, T., May, B., Sato, T., Kido, Y., Takeshi, N., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y., Moore, A.L., Harada, S., Kita, K.
Deposit date:2016-07-19
Release date:2017-07-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of trypanocidal coumarins with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase
To Be Published
5GN7
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CRYSTAL STRUCTURE OF ALTERNATIVE OXIDASE FROM TRYPANOSOMA BRUCEI BRUCEI COMPLEXED WITH CUMARIN DERIVATIVE-17
Descriptor:Alternative oxidase, mitochondrial, FE (III) ION, ...
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, T., May, B., Sato, T., Kido, Y., Takeshi, N., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y., Moore, A.L., Harada, S., Kita, K.
Deposit date:2016-07-19
Release date:2017-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of trypanocidal coumarins with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase
To Be Published
5GN9
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CRYSTAL STRUCTURE OF ALTERNATIVE OXIDASE FROM TRYPANOSOMA BRUCEI BRUCEI COMPLEXED WITH CUMARIN DERIVATIVE-17B
Descriptor:Alternative oxidase, mitochondrial, FE (III) ION, ...
Authors:Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, T., May, B., Sato, T., Kido, Y., Takeshi, N., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y., Moore, A.L., Harada, S., Kita, K.
Deposit date:2016-07-19
Release date:2017-07-26
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of trypanocidal coumarins with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase
To Be Published
5OEY
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN HOLO FORM.
Descriptor:FBP protein, PHOSPHATE ION, MANGANESE (II) ION, ...
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OEZ
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN APO FORM.
Descriptor:FBP protein
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OFU
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN T-STATE.
Descriptor:FBP protein, ADENOSINE MONOPHOSPHATE, FRUCTOSE-6-PHOSPHATE, ...
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-11
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
13PK
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TERNARY COMPLEX OF PHOSPHOGLYCERATE KINASE FROM TRYPANOSOMA BRUCEI
Descriptor:3-PHOSPHOGLYCERATE KINASE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Bernstein, B.E., Michels, P.A.M., Hol, W.G.J.
Deposit date:1996-11-23
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation.
Nature, 385, 1997
1EVY
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-20
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1EVZ
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH NAD
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-21
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1HXI
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AN UNEXPECTED EXTENDED CONFORMATION FOR THE THIRD TPR MOTIF OF THE PEROXIN PEX5 FROM TRYPANOSOMA BRUCEI
Descriptor:PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5, MAGNESIUM ION
Authors:Kumar, A., Roach, C., Hirsh, I.S., Turley, S., deWalque, S., Michels, P.A.M., Hol, W.G.J.
Deposit date:2001-01-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
J.Mol.Biol., 307, 2001
1PKL
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THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE
Descriptor:PROTEIN (PYRUVATE KINASE), SULFATE ION
Authors:Rigden, D.J., Phillips, S.E.V., Michels, P.A.M., Fothergill-Gilmore, L.A.
Deposit date:1998-09-15
Release date:1998-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
J.Mol.Biol., 291, 1999
3CV0
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI PHOSPHOGLUCOISOMERASE (PGI) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor PEX5, T. brucei PGI PTS1 peptide Ac-FNELSHL, 1,2-ETHANEDIOL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-17
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVL
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI PHOSPHOFRUCTOKINASE (PFK) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor PEX5, T. brucei PFK PTS1 peptide Ac-HEELAKL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVN
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STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING DOMAIN OF TRYPANOSOMA BRUCEI PEROXIN 5 (TBPEX5)COMPLEXED TO T. BRUCEI GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) PTS1 PEPTIDE
Descriptor:Peroxisome targeting signal 1 receptor, T. brucei GAPDH PTS1 peptide Ac-DRDAAKL, 1,2-ETHANEDIOL
Authors:Sampathkumar, P., Roach, C., Michels, P.A.M., Hol, W.G.J.
Deposit date:2008-04-18
Release date:2008-06-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
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