5GN7

Crystal structure of alternative oxidase from Trypanosoma brucei brucei complexed with cumarin derivative-17

Summary for 5GN7

Entry DOI	10.2210/pdb5gn7/pdb
Related	3VV9 5GN5 5GN6 5GN9
Descriptor	Alternative oxidase, mitochondrial, FE (III) ION, 4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-7,8-bis(oxidanyl)chromen-2-one, ... (4 entities in total)
Functional Keywords	alternative oxidase, inhibitor, drug, african trypanosomes, oxido-reductase, transferase
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	4
Total formula weight	151453.35
Authors	Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, T.,May, B.,Sato, T.,Kido, Y.,Takeshi, N.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.,Moore, A.L.,Harada, S.,Kita, K. (deposition date: 2016-07-19, release date: 2017-07-26, Last modification date: 2023-11-08)
Primary citation	Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, C.,May, B.,Sato, T.,Kido, Y.,Nara, T.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.I.,Moore, A.L.,Harada, S.,Kita, K. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase ofTrypanosoma brucei brucei. Faseb J., 33:13002-13013, 2019 Cited by PubMed: 31525300 DOI: 10.1096/fj.201901342R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation