3R0J
| Structure of PhoP from Mycobacterium tuberculosis | Descriptor: | POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP, R-1,2-PROPANEDIOL, SULFATE ION | Authors: | Menon, S, Wang, S. | Deposit date: | 2011-03-08 | Release date: | 2011-07-13 | Last modified: | 2014-10-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain. Biochemistry, 50, 2011
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1DB3
| E.COLI GDP-MANNOSE 4,6-DEHYDRATASE | Descriptor: | GDP-MANNOSE 4,6-DEHYDRATASE | Authors: | Somoza, J.R, Menon, S, Somers, W.S, Sullivan, F.X. | Deposit date: | 1999-11-02 | Release date: | 1999-11-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose. Structure Fold.Des., 8, 2000
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1R42
| Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ZINC ION, ... | Authors: | Towler, P, Staker, B, Prasad, S.G, Menon, S, Ryan, D, Tang, J, Parsons, T, Fisher, M, Williams, D, Dales, N.A, Patane, M.A, Pantoliano, M.W. | Deposit date: | 2003-10-07 | Release date: | 2004-02-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J.Biol.Chem., 279, 2004
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1R4L
| Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) | Descriptor: | (S,S)-2-{1-CARBOXY-2-[3-(3,5-DICHLORO-BENZYL)-3H-IMIDAZOL-4-YL]-ETHYLAMINO}-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Towler, P, Staker, B, Prasad, S.G, Menon, S, Ryan, D, Tang, J, Parsons, T, Fisher, M, Williams, D, Dales, N.A, Patane, M.A, Pantoliano, M.W. | Deposit date: | 2003-10-07 | Release date: | 2004-02-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J.Biol.Chem., 279, 2004
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4AAI
| THERMOSTABLE PROTEIN FROM HYPERTHERMOPHILIC VIRUS SSV-RH | Descriptor: | ORF E73 | Authors: | Schlenker, C, Goel, A, Tripet, B.P, Menon, S, Lawrence, C.M, Copie, V. | Deposit date: | 2011-12-02 | Release date: | 2012-01-11 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural Studies of E73 from a Hyperthermophilic Archaeal Virus Identify the "Rh3" Domain, an Elaborated Ribbon-Helix- Helix Motif Involved in DNA Recognition. Biochemistry, 51, 2012
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2WBT
| The Structure of a Double C2H2 Zinc Finger Protein from a Hyperthermophilic Archaeal Virus in the Absence of DNA | Descriptor: | B-129, ZINC ION | Authors: | Eilers, B.J, Menon, S, Windham, A.B, Kraft, P, Dlakic, M, Young, M.J, Lawrence, C.M. | Deposit date: | 2009-03-03 | Release date: | 2010-03-31 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Structure of a Double C2H2 Zinc Finger Protein from a Hyperthermophilic Archaeal Virus in the Absence of DNA To be Published
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4PH4
| The crystal structure of Human VPS34 in complex with PIK-III | Descriptor: | 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3 | Authors: | Knapp, M.S, Elling, R.A. | Deposit date: | 2014-05-04 | Release date: | 2014-10-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat.Cell Biol., 16, 2014
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6NSI
| Crystal structure of Fe(III)-bound YtgA from Chlamydia trachomatis | Descriptor: | CALCIUM ION, FE (III) ION, Manganese-binding protein, ... | Authors: | Luo, Z, Campbell, R, Begg, S.L, Kobe, B, McDevitt, C.A. | Deposit date: | 2019-01-24 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.00006342 Å) | Cite: | Structure and Metal Binding Properties of Chlamydia trachomatis YtgA. J.Bacteriol., 202, 2019
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5TR4
| Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243 | Descriptor: | Ubiquitin, Ubiquitin-activating enzyme E1 1, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate | Authors: | Sintchak, M.D. | Deposit date: | 2016-10-25 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243) To be published
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5YO2
| The crystal structure of Rv2747 from Mycobacterium tuberculosis in complex with Acetyl CoA and L-Arginine | Descriptor: | ACETYL COENZYME *A, ARGININE, Amino-acid acetyltransferase | Authors: | Singh, E, Tiruttani Subhramanyam, U.K, Pal, R.K, Srinivasan, A, Gourinath, S, Das, U. | Deposit date: | 2017-10-26 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.997 Å) | Cite: | Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis Int. J. Biol. Macromol., 125, 2019
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6ADD
| The crystal structure of Rv2747 from Mycobacterium tuberculosis in complex with CoA and NLQ | Descriptor: | Amino-acid acetyltransferase, COENZYME A, N~2~-ACETYL-L-GLUTAMINE | Authors: | Das, U, Singh, E, Pal, R.K, Tiruttani Subhramanyam, U.K, Gourinath, S, Srinivasan, A. | Deposit date: | 2018-07-31 | Release date: | 2018-12-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis Int. J. Biol. Macromol., 125, 2019
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3Q96
| B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor | Descriptor: | (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide, Serine/threonine-protein kinase B-raf | Authors: | Sintchak, M.D, Aertgeerts, K, Yano, J. | Deposit date: | 2011-01-07 | Release date: | 2011-03-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors. J.Med.Chem., 54, 2011
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2CO5
| F93 FROM STIV, a winged-helix DNA-binding protein | Descriptor: | VIRAL PROTEIN F93 | Authors: | Larson, E.T, Reiter, D, Lawrence, C.M. | Deposit date: | 2006-05-25 | Release date: | 2006-05-31 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Winged-Helix Protein from Sulfolobus Turreted Icosahedral Virus Points Toward Stabilizing Disulfide Bonds in the Intracellular Proteins of a Hyperthermophilic Virus. Virology, 368, 2007
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3CUE
| Crystal structure of a TRAPP subassembly activating the Rab Ypt1p | Descriptor: | GTP-binding protein YPT1, PALMITIC ACID, Transport protein particle 18 kDa subunit, ... | Authors: | Cai, Y, Reinisch, K.M. | Deposit date: | 2008-04-16 | Release date: | 2008-07-08 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell(Cambridge,Mass.), 133, 2008
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1VLK
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