5TR4

Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243

Summary for 5TR4

• Entry DOI: 10.2210/pdb5tr4/pdb
• Related: 3CMM
• Descriptor: Ubiquitin-activating enzyme E1 1, Ubiquitin, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate, ... (4 entities in total)
• Functional Keywords: ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Cellular location: Cytoplasm: P22515 P0CG53
• Total number of polymer chains: 4
• Total formula weight: 245586.96

Authors

Sintchak, M.D. (deposition date: 2016-10-25, release date: 2017-11-01, Last modification date: 2023-10-04)

• Primary citation: Hyer, M.,Milhollen, M.,Ciavarri, J.,Fleming, P.,Traore, T.,Sappal, D.,Huck, J.,Shi, J.,Gavin, J.,Brownell, J.,Yang, Y.,Stringer, B.,Griffin, R.,Bruzzese, F.,Soucy, T.,Duffy, J.,Rabino, C.,Riceberg, J.,Hoar, K.,Lublinsky, A.,Menon, S.,Sintchak, M.,Bump, N.,Pulukuri, S.,Amidon, B.,Langston, S.,Tirrell, S.,Kuranda, M.,Veiby, P.,Newcomb, J.,Li, P.,Wu, J.,Dick, L.,Greenspan, P.,Galvin, K.,Manfredi, M.,Claibrone, C.,Bence, N.; Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243); To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)