Author results

6H03
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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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CLOSED CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement component C9, Complement C5,Complement C5, Complement component C8 beta chain, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
5IUX
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GLIC-V135C BIMANE LABELLED X-RAY STRUCTURE
Descriptor:Proton-gated ion channel, DODECYL-BETA-D-MALTOSIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fourati, Z., Menny, A., Delarue, M.
Deposit date:2016-03-18
Release date:2017-03-29
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a pre-active conformation of a pentameric channel receptor.
Elife, 6, 2017
4NPP
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THE GLIC-HIS10 WILD-TYPE STRUCTURE IN EQUILIBRIUM BETWEEN THE OPEN AND LOCALLY-CLOSED (LC) FORMS
Descriptor:Proton-gated ion channel, NICKEL (II) ION
Authors:Sauguet, L., Shahsavar, A., Poitevin, F., Huon, C., Menny, A., Nemecz, A., Haouz, A., Changeux, J.P., Corringer, P.J., Delarue, M.
Deposit date:2013-11-22
Release date:2013-12-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NPQ
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THE RESTING-STATE CONFORMATION OF THE GLIC LIGAND-GATED ION CHANNEL
Descriptor:Proton-gated ion channel
Authors:Sauguet, L., Shahsavar, A., Poitevin, F., Huon, C., Menny, A., Nemecz, A., Haouz, A., Changeux, J.P., Corringer, P.J., Delarue, M.
Deposit date:2013-11-22
Release date:2013-12-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
6HY5
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-19
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HY9
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193M
Descriptor:Proton-gated ion channel, CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-19
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYA
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193L
Descriptor:Proton-gated ion channel, CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-19
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYR
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C+MMTS
Descriptor:Proton-gated ion channel, DODECYL-BETA-D-MALTOSIDE
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYV
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119A
Descriptor:Proton-gated ion channel, DODECYL-BETA-D-MALTOSIDE, ACETATE ION, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYW
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119F
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYX
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C
Descriptor:Proton-gated ion channel, CHLORIDE ION, SODIUM ION, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HYZ
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248C
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HZ0
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248A
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HZ1
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HZ3
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243G
Descriptor:Proton-gated ion channel, CHLORIDE ION
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-22
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HZW
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL 2.22 RESOLUTION
Descriptor:Proton-gated ion channel, ACETATE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-24
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6I08
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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C-I201W
Descriptor:Proton-gated ion channel, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Hu, H.D., Delarue, M.
Deposit date:2018-10-25
Release date:2018-12-19
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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