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5KCX
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PIM-1 KINASE IN COMPLEX WITH A SELECTIVE N-SUBSTITUTED 7-AZAINDOLE INHIBITOR
Descriptor:Serine/threonine-protein kinase pim-1, IMIDAZOLE, ACETATE ION, ...
Authors:Mechin, I., McLean, L.R., Zhang, Y., Wang, R.
Deposit date:2016-06-07
Release date:2017-07-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
5TEL
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PIM-1 KINASE IN COMPLEX WITH A 7-AZAINDOLE
Descriptor:Serine/threonine-protein kinase pim-1, IMIDAZOLE, 4-chloro-2-{5,6-dimethoxy-1-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indol-3-yl}-1H-pyrrolo[2,3-b]pyridine
Authors:Mechin, I., Wang, R., Batchelor, J.D.
Deposit date:2016-09-22
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.214 Å)
Cite:Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
5TEX
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PIM-1 KINASE IN COMPLEX WITH A 7-AZAINDOLE
Descriptor:Serine/threonine-protein kinase pim-1, IMIDAZOLE, (4-{4-chloro-1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methanol
Authors:Mechin, I., Wang, R., Batchelor, J.D., McLean, L.
Deposit date:2016-09-23
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
5TUR
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PIM-1 KINASE IN COMPLEX WITH A 7-AZAINDOLE
Descriptor:Serine/threonine-protein kinase pim-1, 1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile
Authors:Mechin, I., Zhang, Y., Wang, R., Batchelor, J.D., Mclean, L.
Deposit date:2016-11-07
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.948 Å)
Cite:Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
4IAN
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CRYSTAL STRUCTURE OF APO HUMAN PRPF4B KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase PRP4 homolog, SULFATE ION
Authors:Mechin, I., Haas, K., Chen, X., Zhang, Y., McLean, L.
Deposit date:2012-12-06
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
J.Biol.Chem., 288, 2013
4IFC
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CRYSTAL STRUCTURE OF ADP-BOUND HUMAN PRPF4B KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase PRP4 homolog, ADENOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Mechin, I., Haas, K., Chen, X., Zhang, Y., McLean, L.
Deposit date:2012-12-14
Release date:2013-08-28
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
J.Biol.Chem., 288, 2013
4IIR
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CRYSTAL STRUCTURE OF AMPPNP-BOUND HUMAN PRPF4B KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase PRP4 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
Authors:Mechin, I., Haas, K., Chen, X., Zhang, Y., McLean, L.
Deposit date:2012-12-20
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
J.Biol.Chem., 288, 2013
4IJP
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CRYSTAL STRUCTURE OF HUMAN PRPF4B KINASE DOMAIN IN COMPLEX WITH 4-{5-[(2-CHLORO-PYRIDIN-4-YLMETHYL)-CARBAMOYL]-THIOPHEN-2-YL}-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMINE
Descriptor:Serine/threonine-protein kinase PRP4 homolog, 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION
Authors:Mechin, I., Haas, K., Chen, X., Zhang, Y., McLean, L.
Deposit date:2012-12-22
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
J.Biol.Chem., 288, 2013
5TOE
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PIM-1 KINASE IN COMPLEX WITH A 7-AZAINDOLE
Descriptor:Serine/threonine-protein kinase pim-1, 2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile
Authors:Mclean, L., Mechin, I., Zhang, Y., Wang, R., Batchelor, J.D.
Deposit date:2016-10-17
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
1LNS
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CRYSTAL STRUCTURE ANALYSIS OF THE X-PROLYL DIPEPTIDYL AMINOPEPTIDASE FROM LACTOCOCCUS LACTIS
Descriptor:X-PROLYL DIPEPTIDYL AMINOPEPTIDASE
Authors:Rigolet, P., Mechin, I., Delage, M.M., Chich, J.F.
Deposit date:2002-05-03
Release date:2002-11-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for Catalysis and Specificity of the X-prolyl dipepdidyl aminopeptidase from Lactococcus lactis
Structure, 10, 2002
1TJD
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THE CRYSTAL STRUCTURE OF THE REDUCED DISULPHIDE BOND ISOMERASE, DSBC, FROM ESCHERICHIA COLI
Descriptor:Thiol:disulfide interchange protein dsbC
Authors:Banaszak, K., Mechin, I., Frost, G., Rypniewski, W.
Deposit date:2004-06-04
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the reduced disulfide-bond isomerase DsbC from Escherichia coli.
Acta Crystallogr.,Sect.D, 60, 2004
3O8O
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STRUCTURE OF PHOSPHOFRUCTOKINASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:6-phosphofructokinase subunit alpha, 6-phosphofructokinase subunit beta, FRUCTOSE-6-PHOSPHATE, ...
Authors:Banaszak, K., Mechin, I., Kopperschlager, G., Rypniewski, W.
Deposit date:2010-08-03
Release date:2011-02-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
J.Mol.Biol., 407, 2011
3O8L
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STRUCTURE OF PHOSPHOFRUCTOKINASE FROM RABBIT SKELETAL MUSCLE
Descriptor:6-phosphofructokinase, muscle type, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Banaszak, K., Chang, S.H., Rypniewski, W.
Deposit date:2010-08-03
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
J.Mol.Biol., 407, 2011
3O8N
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STRUCTURE OF PHOSPHOFRUCTOKINASE FROM RABBIT SKELETAL MUSCLE
Descriptor:6-phosphofructokinase, muscle type, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Banaszak, K., Chang, S.H., Rypniewski, W.
Deposit date:2010-08-03
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
J.Mol.Biol., 407, 2011