1IKG | | MICHAELIS COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT | | Descriptor: | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANYL-D-ALANINE | | Authors: | Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A. | | Deposit date: | 2001-05-03 | | Release date: | 2002-09-11 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
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1IKI | | COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH THE PRODUCTS OF A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT | | Descriptor: | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANINE, D-ALANINE | | Authors: | Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A. | | Deposit date: | 2001-05-03 | | Release date: | 2002-09-11 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
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1CP9 | |
1NKG | | RHAMNOGALACTURONAN LYASE FROM ASPERGILLUS ACULEATUS | | Descriptor: | Rhamnogalacturonase B, CALCIUM ION, SULFATE ION | | Authors: | McDonough, M.A., Kadirvelraj, R., Harris, P., Poulsen, J.C., Larsen, S. | | Deposit date: | 2003-01-03 | | Release date: | 2004-05-25 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.
Febs Lett., 565, 2004
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1YCI | |
2G1M | |
3ZSC | | CATALYTIC FUNCTION AND SUBSTRATE RECOGNITION OF THE PECTATE LYASE FROM THERMOTOGA MARITIMA | | Descriptor: | PECTATE TRISACCHARIDE-LYASE, 4-deoxy-beta-L-threo-hex-4-enopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid, GLYCEROL, ... | | Authors: | McDonough, M.A., Thymark, M., Frisner, H., Hotchkiss, A., Sonksen, C., Bjornvad, M., Johansen, K.S., Larsen, S. | | Deposit date: | 2011-06-24 | | Release date: | 2012-07-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Catalytic Function and Substrate Recognition of the Pectate Lyase from Thermotoga Maritima
To be Published
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2ZGD | |
2ZGG | |
2ILM | |
3D8C | | FACTOR INHIBITING HIF-1 ALPHA D201G MUTANT IN COMPLEX WITH ZN(II), ALPHA-KETOGLUTARATE AND HIF-1 ALPHA 19MER | | Descriptor: | Hypoxia-inducible factor 1 alpha inhibitor, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ... | | Authors: | McDonough, M.A., Chowdhury, R., Schofield, C.J. | | Deposit date: | 2008-05-23 | | Release date: | 2008-08-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
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1HVB | | CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN | | Descriptor: | D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, 5-{3-(S)-(4-(R)-ACETYLAMINO-4-CARBOXY-BUTYRYLAMINO)-3-[1-(R)-(1-(R)-CARBOXY-ETHYLCARBAMOYL)-ETHYLCARBAMOYL]-PROPYL}-2-(CARBOXY-PHENYLACETYLAMINO-METHYL)-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID | | Authors: | McDonough, M.A., Lee, W., Silvaggi, N.R., Mobashery, S., Kelly, J.A. | | Deposit date: | 2001-01-08 | | Release date: | 2001-02-07 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proc.Natl.Acad.Sci.USA, 98, 2001
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2A1X | | HUMAN PHYTANOYL-COA 2-HYDROXYLASE IN COMPLEX WITH IRON AND 2-OXOGLUTARATE | | Descriptor: | Phytanoyl-CoA dioxygenase, FE (II) ION, 2-OXOGLUTARIC ACID | | Authors: | Kavanagh, K.L., McDonough, M.A., Searles, T., Butler, D., Bunkoczi, G., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-06-21 | | Release date: | 2005-08-16 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease
J.Biol.Chem., 280, 2005
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2CGN | | FACTOR INHIBITING HIF-1 ALPHA WITH SUCCINATE | | Descriptor: | HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, SUCCINIC ACID, ... | | Authors: | McDonough, M.A., Clifton, I.J., Schofield, C.J. | | Deposit date: | 2006-03-09 | | Release date: | 2006-12-13 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
J.Biol.Chem., 282, 2007
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2CGO | | FACTOR INHIBITING HIF-1 ALPHA WITH FUMARATE | | Descriptor: | HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, FUMARIC ACID, ... | | Authors: | McDonough, M.A., Clifton, I.J., Schofield, C.J. | | Deposit date: | 2006-03-09 | | Release date: | 2006-12-13 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
J.Biol.Chem., 282, 2007
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2QC9 | |
3P3N | |
3P3P | |
3UIW | | ZEBRAFISH GRX2 (APO) | | Descriptor: | Glutaredoxin 2, GLUTATHIONE, SULFATE ION | | Authors: | McDonough, M.A., Johansson, C. | | Deposit date: | 2011-11-06 | | Release date: | 2013-03-27 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis
To be Published
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4BP0 | | CRYSTAL STRUCTURE OF THE CLOSED FORM OF PSEUDOMONAS AERUGINOSA SPM-1 | | Descriptor: | METALLO-B-LACTAMASE, ZINC ION, GLYCEROL, ... | | Authors: | McDonough, M.A., Brem, J., Schofield, C.J. | | Deposit date: | 2013-05-22 | | Release date: | 2014-06-18 | | Last modified: | 2019-01-30 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Studying the active-site loop movement of the Sao Paolo metallo-beta-lactamase-1
Chem Sci, 6, 2015
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4CCL | | X-RAY STRUCTURE OF E. COLI YCFD | | Descriptor: | 50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION | | Authors: | McDonough, M.A., Ho, C.H., Kershaw, N.J., Schofield, C.J. | | Deposit date: | 2013-10-23 | | Release date: | 2014-04-30 | | Last modified: | 2020-06-03 | | Method: | X-RAY DIFFRACTION (2.596 Å) | | Cite: | Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
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4CSW | | RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE | | Descriptor: | CUPIN 4 FAMILY PROTEIN, CITRIC ACID, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... | | Authors: | McDonough, M.A., Sekirnik, R., Schofield, C.J. | | Deposit date: | 2014-03-11 | | Release date: | 2014-04-09 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (2.821 Å) | | Cite: | Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
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4CUG | | RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE IN COMPLEX SUBSTRATE FRAGMENT | | Descriptor: | CUPIN 4 FAMILY PROTEIN, 50S RIBOSOMAL PROTEIN L16, MANGANESE (II) ION, ... | | Authors: | McDonough, M.A., Sekirnik, R., Schofield, C.J. | | Deposit date: | 2014-03-18 | | Release date: | 2014-04-16 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
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4CWD | | CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE | | Descriptor: | GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ... | | Authors: | McDonough, M.A., Kochan, G., Rydzik, A., Schofield, C.J. | | Deposit date: | 2014-04-02 | | Release date: | 2014-09-17 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (1.899 Å) | | Cite: | Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
Angew. Chem. Int. Ed. Engl., 53, 2014
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4YR7 | |
