Author results

1DCQ
  • Download 1dcq
  • View 1dcq
Molmil generated image of 1dcq
CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA.
Descriptor:PYK2-ASSOCIATED PROTEIN BETA, ZINC ION
Authors:Mandiyan, V., Andreev, J., Schlessinger, J., Hubbard, S.R.
Deposit date:1999-11-05
Release date:1999-12-22
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
EMBO J., 18, 1999
1YWV
  • Download 1ywv
  • View 1ywv
Molmil generated image of 1ywv
CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-18
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXS
  • Download 1yxs
  • View 1yxs
Molmil generated image of 1yxs
CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXT
  • Download 1yxt
  • View 1yxt
Molmil generated image of 1yxt
CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXU
  • Download 1yxu
  • View 1yxu
Molmil generated image of 1yxu
CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, ADENOSINE MONOPHOSPHATE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
1YXV
  • Download 1yxv
  • View 1yxv
Molmil generated image of 1yxv
CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
1YXX
  • Download 1yxx
  • View 1yxx
Molmil generated image of 1yxx
CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
2E9W
  • Download 2e9w
  • View 2e9w
Molmil generated image of 2e9w
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF KIT IN COMPLEX WITH STEM CELL FACTOR (SCF)
Descriptor:Mast/stem cell growth factor receptor, Kit ligand, N-ACETYL-D-GLUCOSAMINE
Authors:Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2007-01-27
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
2EC8
  • Download 2ec8
  • View 2ec8
Molmil generated image of 2ec8
CRYSTAL STRUCTURE OF THE EXCTRACELLULAR DOMAIN OF THE RECEPTOR TYROSINE KINASE, KIT
Descriptor:Mast/stem cell growth factor receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2007-02-11
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
3JS2
  • Download 3js2
  • View 3js2
Molmil generated image of 3js2
CRYSTAL STRUCTURE OF MINIMAL KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH 5-(2-THIENYL)NICOTINIC ACID
Descriptor:Basic fibroblast growth factor receptor 1, 5-(2-thienyl)nicotinic acid, PHOSPHATE ION
Authors:Bae, J.H., Ravindranathan, K.P., Mandiyan, V., Ekkati, A.R., Schlessinger, J., Jorgensen, W.L.
Deposit date:2009-09-09
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening
J.Med.Chem., 53, 2010
3KXX
  • Download 3kxx
  • View 3kxx
Molmil generated image of 3kxx
STRUCTURE OF THE MUTANT FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor:Basic fibroblast growth factor receptor 1
Authors:Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2009-12-04
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KY2
  • Download 3ky2
  • View 3ky2
Molmil generated image of 3ky2
CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE DOMAIN
Descriptor:Basic fibroblast growth factor receptor 1, SULFATE ION
Authors:Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.
Deposit date:2009-12-04
Release date:2010-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
1HSQ
  • Download 1hsq
  • View 1hsq
Molmil generated image of 1hsq
SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
Descriptor:PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)
Authors:Kohda, D., Hatanaka, H., Odaka, M., Inagaki, F.
Deposit date:1994-06-13
Release date:1994-08-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the SH3 domain of phospholipase C-gamma.
Cell(Cambridge,Mass.), 72, 1993
1IO6
  • Download 1io6
  • View 1io6
Molmil generated image of 1io6
GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (GRB2) C-TERMINAL SH3 DOMAIN COMPLEXED WITH A LIGAND PEPTIDE (NMR, MINIMIZED MEAN STRUCTURE)
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, A LIGAND PEPTIDE
Authors:Kawasaki, M., Ogura, K., Hatanaka, H., Inagaki, F.
Deposit date:2001-01-25
Release date:2001-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the C-Terminal SH3 Domain of Grb2 Complexed with a Ligand Peptide: A Ligand Exchange Model of the SH3 Domain
To be Published
2HSP
  • Download 2hsp
  • View 2hsp
Molmil generated image of 2hsp
SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
Descriptor:PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)
Authors:Kohda, D., Hatanaka, H., Odaka, M., Inagaki, F.
Deposit date:1994-06-13
Release date:1994-08-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the SH3 domain of phospholipase C-gamma.
Cell(Cambridge,Mass.), 72, 1993
1AQC
  • Download 1aqc
  • View 1aqc
Molmil generated image of 1aqc
X11 PTB DOMAIN-10MER PEPTIDE COMPLEX
Descriptor:X11, PEPTIDE
Authors:Lee, C.-H., Zhang, Z., Kuriyan, J.
Deposit date:1997-07-28
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
EMBO J., 16, 1997
1GCP
  • Download 1gcp
  • View 1gcp
Molmil generated image of 1gcp
CRYSTAL STRUCTURE OF VAV SH3 DOMAIN
Descriptor:VAV PROTO-ONCOGENE
Authors:Nishida, M., Nagata, K., Hachimori, Y., Ogura, K., Inagaki, F.
Deposit date:2000-08-08
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel recognition mode between Vav and Grb2 SH3 domains.
EMBO J., 20, 2001
1GCQ
  • Download 1gcq
  • View 1gcq
Molmil generated image of 1gcq
CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, VAV PROTO-ONCOGENE, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Nishida, M., Nagata, K., Hachimori, Y., Ogura, K., Inagaki, F.
Deposit date:2000-08-08
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Novel recognition mode between Vav and Grb2 SH3 domains.
EMBO J., 20, 2001
1GFC
  • Download 1gfc
  • View 1gfc
Molmil generated image of 1gfc
SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE C-TERMINAL SH3 DOMAIN OF GRB2
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Kohda, D., Terasawa, H., Hatanaka, H., Inagaki, F.
Deposit date:1994-06-13
Release date:1994-08-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure, 2, 1994
1GFD
  • Download 1gfd
  • View 1gfd
Molmil generated image of 1gfd
SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE C-TERMINAL SH3 DOMAIN OF GRB2
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Kohda, D., Terasawa, H., Hatanaka, H., Inagaki, F.
Deposit date:1994-06-13
Release date:1994-08-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure, 2, 1994
1QG1
  • Download 1qg1
  • View 1qg1
Molmil generated image of 1qg1
GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE
Descriptor:PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN), PROTEIN (SHC-DERIVED PEPTIDE)
Authors:Ogura, K.
Deposit date:1999-04-19
Release date:1999-04-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
J.Mol.Biol., 289, 1999
1X11
  • Download 1x11
  • View 1x11
Molmil generated image of 1x11
X11 PTB DOMAIN
Descriptor:X11, 13-MER PEPTIDE
Authors:Lee, C.-H., Zhang, Z., Kuriyan, J.
Deposit date:1997-07-28
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
EMBO J., 16, 1997